Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ayyalusamy R"'
Autor:
Samuel D. McCalpin, Lucie Khemtemourian, Saba Suladze, Magdalena I. Ivanova, Bernd Reif, Ayyalusamy Ramamoorthy
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Aggregation of the human islet amyloid polypeptide (hIAPP) contributes to the development and progression of Type 2 Diabetes (T2D). hIAPP aggregates within a few hours at few micromolar concentration in vitro but exists at millimolar concent
Externí odkaz:
https://doaj.org/article/76196303c8fc41bb85c71773c058e15d
Akademický článek
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Publikováno v:
Membranes, Vol 14, Iss 8, p 168 (2024)
Lipids have not traditionally been considered likely candidates for catalyzing reactions in biological systems. However, there is significant evidence that aggregates of amphiphilic compounds are capable of catalyzing reactions in synthetic organic c
Externí odkaz:
https://doaj.org/article/07361476c2b14a71b383645cf5891497
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 320 (2024)
Antimicrobial peptides (AMPs), as well as host defense peptides (HDPs), constitute the first line of defense as part of the innate immune system. Humans are known to express antimicrobial precursor proteins, which are further processed to generate AM
Externí odkaz:
https://doaj.org/article/461004323080430daa86aada4d2726b9
Autor:
Bankala Krishnarjuna, Thirupathi Ravula, Edgar M. Faison, Marco Tonelli, Qi Zhang, Ayyalusamy Ramamoorthy
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1628 (2022)
Residual dipolar couplings (RDCs) are increasingly used for high-throughput NMR-based structural studies and to provide long-range angular constraints to validate and refine structures of various molecules determined by X-ray crystallography and NMR
Externí odkaz:
https://doaj.org/article/ec8eb75b673b4c218dec2efe16460e36
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1076 (2022)
Atomic-resolution structural studies of membrane-associated proteins and peptides in a membrane environment are important to fully understand their biological function and the roles played by them in the pathology of many diseases. However, the compl
Externí odkaz:
https://doaj.org/article/91a1d7ccc4de470e90f257109913ce47
Autor:
Yunlong Zhou, Pablo F. Damasceno, Bagganahalli S. Somashekar, Michael Engel, Falin Tian, Jian Zhu, Rui Huang, Kyle Johnson, Carl McIntyre, Kai Sun, Ming Yang, Peter F. Green, Ayyalusamy Ramamoorthy, Sharon C. Glotzer, Nicholas A. Kotov
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Achieving simultaneous high storage and loss moduli in gels is difficult due to the opposite chemical structure requirements needed for such properties. Here the authors show a spectrum of gels containing CdTe nanoparticles stabilized by glutathione
Externí odkaz:
https://doaj.org/article/191c03ddfe8f472d84400df2efcd484d
Autor:
Katherine A. Gentry, Elke Prade, Carlo Barnaba, Meng Zhang, Mukesh Mahajan, Sang-Choul Im, G. M. Anantharamaiah, Satoshi Nagao, Lucy Waskell, Ayyalusamy Ramamoorthy
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Cytochrome b 5 (cytb 5) is a membrane protein vital for the regulation of cytochrome P450 (cytP450) metabolism and is capable of electron transfer to many redox partners. Here, using cyt c as a surrogate for cytP450, we report the effect of
Externí odkaz:
https://doaj.org/article/25723ddda3f34b8b832c8fae21511602
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The dynamic protein-protein and protein-ligand interactions of integral bitopic membrane proteins with a single membrane-spanning helix play a plethora of vital roles in the cellular processes associated with human health and diseases, inclu
Externí odkaz:
https://doaj.org/article/d6fc88d914294a2a968b2df38f418938
Autor:
Diana C Rodriguez Camargo, Kyle J Korshavn, Alexander Jussupow, Kolio Raltchev, David Goricanec, Markus Fleisch, Riddhiman Sarkar, Kai Xue, Michaela Aichler, Gabriele Mettenleiter, Axel Karl Walch, Carlo Camilloni, Franz Hagn, Bernd Reif, Ayyalusamy Ramamoorthy
Publikováno v:
eLife, Vol 6 (2017)
Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death. While structures of membrane-associated intermediates would provide tremendous insights into
Externí odkaz:
https://doaj.org/article/83e9a3672fef478bbca4e26152d644a1