Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ayyakkannu Ayyanan"'
Autor:
Johan Staaf, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Siker Kimbung, Ingrid Hedenfalk, Tonje Lien, Therese Sørlie, Bjørn Naume, Hege Russnes, Rachel Marcone, Ayyakkannu Ayyanan, Cathrin Brisken, Rebecka R. Malterling, Bengt Asking, Helena Olofsson, Henrik Lindman, Pär-Ola Bendahl, Anna Ehinger, Christer Larsson, Niklas Loman, Lisa Rydén, Martin Malmberg, Åke Borg, Johan Vallon-Christersson
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and risk of recurrence (
Externí odkaz:
https://doaj.org/article/d2e56c524d0b4a448d746df4499518bd
Autor:
Valentina Scabia, Ayyakkannu Ayyanan, Fabio De Martino, Andrea Agnoletto, Laura Battista, Csaba Laszlo, Assia Treboux, Khalil Zaman, Athina Stravodimou, Didier Jallut, Maryse Fiche, Philip Bucher, Giovanna Ambrosini, George Sflomos, Cathrin Brisken
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The role of progesterone receptor (PR) and its interplay with estrogen receptor (ER) in breast cancer is controversial. Here, the authors demonstrate that PR can have an ER-independent role in breast cancer growth and metastasis and that its effects
Externí odkaz:
https://doaj.org/article/e90383a7e88449f6abdfb06422e18297
Autor:
Stéphanie Cagnet, Dalya Ataca, George Sflomos, Patrick Aouad, Sonia Schuepbach-Mallepell, Henry Hugues, Andrée Krust, Ayyakkannu Ayyanan, Valentina Scabia, Cathrin Brisken
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Oestrogen receptors α (ERα) are expressed in a subset of mammary epithelial cells. Here, the authors identify cells with low-ERα protein levels and show that distinct cell populations have distinct requirements for the AF1 and AF2 domains of the E
Externí odkaz:
https://doaj.org/article/648ebe25ccab4e248c751792d692bd28
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
Autor:
George Sflomos, Laura Battista, Patrick Aouad, Fabio De Martino, Valentina Scabia, Athina Stravodimou, Ayyakkannu Ayyanan, Assia Ifticene‐Treboux, RLS, Philipp Bucher, Maryse Fiche, Giovanna Ambrosini, Cathrin Brisken
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Abstract Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other estrogen receptor‐positive (ER+) breast canc
Externí odkaz:
https://doaj.org/article/8496cd22d6914407af3da1471f234dcb
Autor:
Reseau Lausannois du Sein, Cathrin Brisken, George Sflomos, Assia Treboux, Laura Battista, Valentina Scabia, Khalil Zaman, Maryse Fiche, Ayyakkannu Ayyanan, Athina Stravodimou
Estrogen receptor α positive (ER+) or “luminal” breast cancers were notoriously difficult to establish as patient-derived xenografts (PDXs). We and others recently demonstrated that the microenvironment is critical for ER+ tumor cells; by grafti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb0b7d4448cf3203f8c0778f827c103
https://doi.org/10.1101/409177
https://doi.org/10.1101/409177
Autor:
Athina Stravodimou, Assia Treboux, Patrick Aouad, Khalil Zaman, Ayyakkannu Ayyanan, Maryse Fiche, Valérian Dormoy, Valentina Scabia, Cathrin Brisken, George Sflomos, Laura Battista
Publikováno v:
The Journal of Pathology
Journal of Pathology
Journal of Pathology, Wiley, 2019, 247 (3), pp.287-292. ⟨10.1002/path.5200⟩
The Journal of pathology, vol. 247, no. 3, pp. 287-292
Journal of Pathology
Journal of Pathology, Wiley, 2019, 247 (3), pp.287-292. ⟨10.1002/path.5200⟩
The Journal of pathology, vol. 247, no. 3, pp. 287-292
Estrogen receptor α‐positive (ER‐positive) or ‘luminal’ breast cancers were notoriously difficult to establish as patient‐derived xenografts (PDXs). We and others recently demonstrated that the microenvironment is critical for ER‐positiv
Autor:
Tauno Metsalu, Assya Treboux, Jaak Vilo, Valérian Dormoy, George Sflomos, Jean-François Delaloye, Cathrin Brisken, Ayyakkannu Ayyanan, Wassim Raffoul, Valentina Scabia, Laura Battista, Maryse Fiche, Rachel Jeitziner
Publikováno v:
Cancer Cell
Cancer Cell, Elsevier, 2016, 29 (3), pp.407-422. ⟨10.1016/j.ccell.2016.02.002⟩
Cancer Cell, Elsevier, 2016, 29 (3), pp.407-422. ⟨10.1016/j.ccell.2016.02.002⟩
Summary Seventy-five percent of breast cancers are estrogen receptor α positive (ER + ). Research on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require non-physiological hormone supplements, and patient-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4507f22ca97dbde4cf7e0b9e2c6487a
https://hal.univ-reims.fr/hal-02431957
https://hal.univ-reims.fr/hal-02431957
Autor:
Maria Gutierrez, Ayyakkannu Ayyanan, Gregory Lefebvre, Sonia Schuepbach-Mallepell, Jacques Rougemont, Ozden Yalcin-Ozuysal, Christina Schrick, Cathrin Brisken, Tamara Tanos, Ouahiba Laribi
Publikováno v:
Molecular Endocrinology. 25:1915-1923
Bisphenol A [BPA, 2,2,-bis (hydroxyphenyl) propane] is one of the highest-volume chemicals produced worldwide. It is detected in body fluids of more than 90% of the human population. Originally synthesized as an estrogenic compound, it is currently u
Autor:
Rui Yu Wang, Cathrin Brisken, Venkata Lokesh Battula, Brett G. Hollier, Rudy Guerra, Yuexi Shi, Ayyakkannu Ayyanan, Sendurai A. Mani, Kurt W. Evans, Michael Andreeff, Frank C. Marini
Publikováno v:
Stem Cells. 28:1435-1445
The epithelial-to-mesenchymal transition (EMT) is an embryonic process that becomes latent in most normal adult tissues. Recently, we have shown that induction of EMT endows breast epithelial cells with stem cell traits. In this report, we have furth
Autor:
William C. Dougall, Ayyakkannu Ayyanan, Jean-François Delaloye, Pascal Schneider, Pablo Christian Echeverria, Tamara Tanos, Maria Gutierrez, Wassim Raffoul, Ozden Yalcin-Ozuysal, George Sflomos, Maryse Fiche, Cathrin Brisken
Publikováno v:
Science translational medicine
Science Translational Medicine, Vol. 5, No 182 (2013) pp. 1-10
Science Translational Medicine, Vol. 5, No 182 (2013) pp. 1-10
Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear f