Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ayumi Okochi"'
Autor:
Takeshi Otani, Masayoshi Kibata, Akira Sugimoto, Shuji Nakamura, Ayumi Okochi, Terumasa Toraya, Makoto Takeuchi, Motoyuki Suzuki, Fumiyuki Yamasaki
Publikováno v:
Journal of Immunological Methods. 372:78-88
A number of T cell subsets have been identified, and the in vitro characterization of these subsets largely depends on an appropriate induction system for each one. In previous studies, we characterized a unique T cell line, HOZOT, which possessed a
Autor:
Masayoshi Kibata, Fumiyuki Yamasaki, Akira Sugimoto, Ayumi Okochi, Motoyuki Suzuki, Takeshi Otani, Shuji Nakamura, Makoto Takeuchi
Publikováno v:
Experimental Hematology. 37:1454-1463
Objective HOZOT cell lines (HOZOTs) are a new type of regulatory T cells established from human umbilical cord blood without using cytokines. In addition to their unique FOXP3 + CD4 + CD8 + CD25 + phenotype, HOZOTs are bifunctional and can exert eith
Autor:
Makoto Takeuchi, Toshiya Inoue, Ayumi Okochi, Shuji Nakamura, Akira Harashima, Masayoshi Kibata, Kazue Tsuji-Takayama, Takeshi Otani, Fumiyuki Yamasaki, Motoyuki Suzuki, Mayuko Yamamoto, Akira Sugimoto, Terumasa Toraya
Publikováno v:
Molecular Immunology. 46:3310-3319
Distinct cytokine production profiles define the effector functions of both helper and regulatory T cells. Recently, we established novel cytotoxic regulatory T (Treg) cell lines, HOZOT, which have been characterized as IL-10-producing T cells. In th
Autor:
Masayoshi Kibata, Shuji Nakamura, Akira Sugimoto, Kazue Tsuji-Takayama, Motoyuki Suzuki, Toshiya Inoue, Terumasa Toraya, Mayuko Yamamoto, Takeshi Otani, Akira Harashima, Fumiyuki Yamasaki, Ayumi Okochi, Makoto Takeuchi
Publikováno v:
The Journal of Immunology. 181:3897-3905
STAT5 molecules are key components of the IL-2 signaling pathway, the deficiency of which often results in autoimmune pathology due to a reduced number of CD4+CD25+ naturally occurring regulatory T (Treg) cells. One of the consequences of the IL-2-ST
Autor:
Akira Sugimoto, Ryuichi Motoda, Kunzo Orita, Ayumi Okochi, Masayoshi Kibata, Toshiya Inoue, Kazue Tsuji-Takayama, Mayuko Yamamoto, Shuji Nakamura, Motoyuki Suzuki, Akira Harashima, Takeshi Otani, Fumiyuki Yamasaki
Publikováno v:
Experimental Hematology. 35:287-296
Objective Since the existence of mouse naturally occurring CD4 + CD25 + T regulatory (Treg) cells was demonstrated, a variety of human Treg subsets have been identified as distinct T cell populations. Here we show the establishment of novel Treg cell
Autor:
Akira Harashima, Hans G. Drexler, Ryuichi Motoda, Yoshinobu Matsuo, Ayumi Okochi, Mitsune Tanimoto, Kunzo Orita
Publikováno v:
Leukemia Research. 29:841-848
A number of transcription factors (TFs) have been reported that play crucial roles in hematopoiesis. However, only little is known about how these factors are involved in the mechanisms of hematopoietic development and lineage commitment. To investig
Autor:
Shoji Asakura, Kensuke Kojima, Akira Harashima, Ayumi Okochi, Hans G. Drexler, Mitsune Tanimoto, Yoshinobu Matsuo, Kunzo Orita
Publikováno v:
Leukemia Research. 29:701-710
The two acute myelomonocytic leukemia sister cell lines MOLM-17 and MOLM-18 and the Epstein-Barr-virus positive non-malignant B-lymphoblastoid cell lines (B-LCLs) B422 and B423 were established from the bone marrow sample of a 60-year-old Japanese ma
Autor:
Hans G. Drexler, Akira Harashima, Kensuke Kojima, Ayumi Okochi, Atsuhiko Hasegawa, Kunzo Orita, Yoshinobu Matsuo
Publikováno v:
Leukemia Research. 28:869-877
The novel multiple myeloma (MM) cell line MOLP-8 carrying the t(11;14) (q13;q32) was established from the peripheral blood of a 52-year-old Japanese male patient with Bence-Jones delta/lambda type MM (stage IIIA with hyperammonemia). The growth of MO
Autor:
Akira Harashima, Tamotsu Yoshioka, Mayuko Yamamoto, Ayumi Okochi, Kunzo Orita, Motoyuki Suzuki, Yoshinobu Matsuo, Ryuichi Motoda
Publikováno v:
Experimental Hematology. 30:1132-1138
Objective Several investigators have reported that transforming growth factor (TGF)- β 1 and granulocyte-macrophage colony-stimulating factor (GM-CSF) synergistically support cell proliferation. However, the mechanisms involved have not been elucida
Autor:
Akira Harashima, Motoyuki Suzuki, Mayuko Yamamoto, Fumiyuki Yamasaki, Ayumi Okochi, Ryuichi Motoda, Shuji Nakamura, Kunzo Orita
Publikováno v:
American Journal of Hematology. 77:313-315
DNA methylation plays important roles in a wide range of biological phenomena, especially in the embryonic development and tumorigenesis. However, correlations between differentiation and DNA methylation have not been clarified well in each different