Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ayumi Ohoka-Sugita"'
Autor:
Daisuke Yamamoto, Akira Hiratate, Tomomichi Chonan, Miyoko Yashiro, Daisuke Wakasugi, Fusayo Io, Hiroko Koretsune, Hiroaki Tanaka, Ayumi Ohoka-Sugita, Takahiro Oi
Publikováno v:
Bioorganicmedicinal chemistry. 19(5)
Novel (4-piperidinyl)-piperazine derivatives were synthesized and evaluated as ACC1/2 non-selective inhibitors. Optimization of the substituents on the nitrogen of the piperidine ring led to the identification of the fluorine substituted tert-butoxyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ea50dd0e25d528dafcbbd54f81a2a0
https://pubmed.ncbi.nlm.nih.gov/21324704
https://pubmed.ncbi.nlm.nih.gov/21324704
Autor:
Daisuke Yamamoto, Akira Hiratate, Hiroaki Tanaka, Tomomichi Chonan, Miyoko Yashiro, Hiroko Koretsune, Daisuke Wakasugi, Ayumi Ohoka-Sugita, Fusayo Io, Takahiro Oi
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(13)
Acetyl-CoA carboxylases (ACCs), the rate limiting enzymes in de novo lipid synthesis, play important roles in modulating energy metabolism. The inhibition of ACC has demonstrated promising therapeutic potential for treating obesity and type 2 diabete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a1ddd265e2e82373209c50ac95e2b3
https://pubmed.ncbi.nlm.nih.gov/20537533
https://pubmed.ncbi.nlm.nih.gov/20537533
Autor:
Daisuke Wakasugi, Takahiro Oi, Miyoko Yashiro, Hiroaki Tanaka, Ayumi Ohoka-Sugita, Tomomichi Chonan, Akira Hiratate, Fusayo Io, Hiroko Koretsune, Daisuke Yamamoto
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(23)
Acetyl-CoA carboxylases (ACCs), the rate limiting enzymes in de novo lipid synthesis, play important roles in modulating energy metabolism. The inhibition of ACC has demonstrated promising therapeutic potential for treating obesity and type 2 diabete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e245dbea7d6c7f08aaf8c4ff99264571
https://pubmed.ncbi.nlm.nih.gov/19853443
https://pubmed.ncbi.nlm.nih.gov/19853443