Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ayumi Oguma"'
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185357 (2017)
Our previous study on prion-infected rodents revealed that hydroxypropyl methylcellulose compounds (HPMCs) with different molecular weights but similar composition and degree of substitution have different levels of long-lasting anti-prion activity.
Externí odkaz:
https://doaj.org/article/06599ca759124adaa35fef3def57aaee
Autor:
Kenta Teruya, Ayumi Oguma, Keiko Nishizawa, Maki Kawata, Yuji Sakasegawa, Hiroshi Kamitakahara, Katsumi Doh-Ura
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006045 (2016)
Prion diseases are fatal, progressive, neurodegenerative diseases caused by prion accumulation in the brain and lymphoreticular system. Here we report that a single subcutaneous injection of cellulose ethers (CEs), which are commonly used as inactive
Externí odkaz:
https://doaj.org/article/954ad1123584407cb827ca9f7b91f243
Autor:
Keita Arai, Ayumi Oguma, Miki Watanabe-Matsui, Kenta Teruya, Yuji Sakasegawa, Keiko Nishizawa, Sabine Gilch, Sara Iwabuchi, Katsumi Doh-ura, Hermann M. Schätzl
Publikováno v:
Biochemical and Biophysical Research Communications. 560:105-111
Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea04cc86735f8eb92b9e6f932392386
https://doi.org/10.1016/j.bbrc.2021.04.116
https://doi.org/10.1016/j.bbrc.2021.04.116
Autor:
Mingxuan Ding, Wen-Quan Zou, Weiguanliu Zhang, Justin J. Greenlee, Hae Weon Lee, Jue Yuan, Kenta Teruya, Katsumi Doh-ura, Marcus Mitchell, Manuel V. Camacho, Li Cui, Ayumi Oguma, Aaron Foutz, Qingzhong Kong
Publikováno v:
Molecular Neurobiology
Previous studies have revealed that the infectious scrapie isoform of prion protein (PrPSc) harbored in the skin tissue of patients or animals with prion diseases can be amplified and detected through the serial protein misfolding cyclic amplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66eff35c7f2f9acf75a0ad6b0dca6afe
https://doi.org/10.1007/s12035-021-02418-6
https://doi.org/10.1007/s12035-021-02418-6
Autor:
Kenta Teruya, Ayumi Oguma, Satoko Takahashi, Miki Watanabe-Matsui, Sachiyo Tsuji-Kawahara, Masaaki Miyazawa, Katsumi Doh-ura
Publikováno v:
International immunopharmacology. 107
The anti-prion activity of cellulose ether (CE) has been reported in rodents, but the mechanism of action is not well understood. As defects in early T-cell development have been reported in Tga20 mice which show only a slight effect of CE administra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f469fcdc2c4be280297004de4deca3
https://pubmed.ncbi.nlm.nih.gov/35279511
https://pubmed.ncbi.nlm.nih.gov/35279511
Autor:
Keiko Nishizawa, Sabine Gilch, Katsumi Doh-ura, Ayumi Oguma, Hermann M. Schätzl, Kenta Teruya, Yuji Sakasegawa
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2814-2820
Prion accumulation in the brain and lymphoreticular system causes fatal neurodegenerative diseases. Our previous study revealed that cellulose ethers (CE) have anti-prion activities in vivo and in prion-infected cells when administered at high doses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922bfe0f2115fa1c3dca4cdb55d36e66
https://doi.org/10.1016/j.xphs.2019.03.025
https://doi.org/10.1016/j.xphs.2019.03.025
Autor:
Keiko Nishizawa, Kenta Teruya, Ayumi Oguma, Yuji Sakasegawa, Katsumi Doh-ura, Tetsuyuki Kitamoto
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:384-394
In prion diseases, infectious pathogenic particles that are composed of abnormal prion proteins (PrPSc) accumulate in the brain. PrPSc is biochemically characterized by its protease-resistance core (PrPres), but its structural features have not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dc70cf53e79e9a5edd5b2bce28a29b
https://doi.org/10.1016/j.bbagen.2018.11.008
https://doi.org/10.1016/j.bbagen.2018.11.008
Autor:
Taichi Hamanaka, Hiroshi Kurahashi, Katsumi Doh-ura, Ayumi Oguma, Keiko Nishizawa, Kenta Teruya, Yuji Sakasegawa
Publikováno v:
Biochemistry and Biophysics Reports
No remedies for prion disease have been established, and the conversion of normal to abnormal prion protein, a key event in prion disease, is still unclear. Here we found that substances in beetle grub hemolymph, after they were browned by aging for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dfc841bd8f620bc01d8a2d1b4b8535
https://doi.org/10.1016/j.bbrep.2015.07.009
https://doi.org/10.1016/j.bbrep.2015.07.009
Publikováno v:
Journal of Virology. 88:4083-4099
A new type of antiprion compound, Gly-9, was found to inhibit abnormal prion protein formation in prion-infected neuroblastoma cells, in a prion strain-independent manner, when the cells were treated for more than 1 day. It reduced the intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b8ab49ed494e8732dda05ffa7df5eb
https://doi.org/10.1128/jvi.03775-13
https://doi.org/10.1128/jvi.03775-13
Autor:
Maki Kawata, Ayumi Oguma, Keiko Nishizawa, Kenta Teruya, Yuji Sakasegawa, Hiroshi Kamitakahara, Katsumi Doh-ura
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006045 (2016)
PLoS Pathogens
PLoS Pathogens
Prion diseases are fatal, progressive, neurodegenerative diseases caused by prion accumulation in the brain and lymphoreticular system. Here we report that a single subcutaneous injection of cellulose ethers (CEs), which are commonly used as inactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa57b424cc9d4a13d297863e1eaf1e5
http://hdl.handle.net/2433/218505
http://hdl.handle.net/2433/218505