Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ayumi Kitano"'
Autor:
Yu-Jung Tseng, Yuki Kageyama, Rebecca L. Murdaugh, Ayumi Kitano, Jong Hwan Kim, Kevin A. Hoegenauer, Jonathan Tiessen, Mackenzie H. Smith, Hidetaka Uryu, Koichi Takahashi, James F. Martin, Md Abul Hassan Samee, Daisuke Nakada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Hematopoietic stem cells (HSCs) are capable of regenerating the blood system, but the instructive cues that direct HSCs to regenerate particular lineages lost to the injury remain elusive. Here, we show that iron is increasingly taken up by
Externí odkaz:
https://doaj.org/article/e2f9fc0f56c34621b4e2cc5d8cfc94a7
Autor:
Tianyuan Hu, Ayumi Kitano, Victor Luu, Brian Dawson, Kevin A. Hoegenauer, Brendan H. Lee, Daisuke Nakada
Publikováno v:
Stem Cell Reports, Vol 13, Iss 3, Pp 545-558 (2019)
Summary: Bone marrow stromal cells (BMSCs) that express high levels of stem cell factor (SCF) and CXC chemokine ligand 12 (CXCL12) are one crucial component of the hematopoietic stem cell (HSC) niche. While the secreted factors produced by BMSCs to s
Externí odkaz:
https://doaj.org/article/c8c428a2d16c435485b011926466eb70
Autor:
Richard H. Chapple, Yu-Jung Tseng, Tianyuan Hu, Ayumi Kitano, Makiko Takeichi, Kevin A. Hoegenauer, Daisuke Nakada
Publikováno v:
Blood Advances, Vol 2, Iss 11, Pp 1220-1228 (2018)
Abstract: Characterization of hematopoietic stem cells (HSCs) has advanced largely owing to transplantation assays, in which the developmental potential of HSCs is assessed generally in nonhomeostatic conditions. These studies established that adult
Externí odkaz:
https://doaj.org/article/17faef94eeb64608a045a97281fc5f72
Autor:
Michael C. Gundry, Lorenzo Brunetti, Angelique Lin, Allison E. Mayle, Ayumi Kitano, Dimitrios Wagner, Joanne I. Hsu, Kevin A. Hoegenauer, Cliona M. Rooney, Margaret A. Goodell, Daisuke Nakada
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1453-1461 (2016)
Summary: Our understanding of the mechanisms that regulate hematopoietic stem/progenitor cells (HSPCs) has been advanced by the ability to genetically manipulate mice; however, germline modification is time consuming and expensive. Here, we describe
Externí odkaz:
https://doaj.org/article/a84ef1ca22b448db80fbb63ddf1b86b6
Autor:
Richard H Chapple, Tianyuan Hu, Yu-Jung Tseng, Lu Liu, Ayumi Kitano, Victor Luu, Kevin A Hoegenauer, Takao Iwawaki, Qing Li, Daisuke Nakada
Publikováno v:
eLife, Vol 7 (2018)
Activation of the unfolded protein response (UPR) sustains protein homeostasis (proteostasis) and plays a fundamental role in tissue maintenance and longevity of organisms. Long-range control of UPR activation has been demonstrated in invertebrates,
Externí odkaz:
https://doaj.org/article/7030bcdb383e4e07a7362260110fcf20
Autor:
Richard H. Chapple, Matthew C. Hill, James F. Martin, Angelique Lin, Nicolas L. Young, Matthew V. Holt, Ayumi Kitano, Xiangguo Shi, Tianyuan Hu, Daisuke Nakada, Yu-Jung Tseng, Jonathan F. Tiessen, Kevin A. Hoegenauer, Rebecca Murdaugh
Publikováno v:
Stem Cell Reports
Summary Histone variants contribute to the complexity of the chromatin landscape and play an integral role in defining DNA domains and regulating gene expression. The histone H3 variant H3.3 is incorporated into genic elements independent of DNA repl
Autor:
Katharina Wohlan, Lorenzo Brunetti, Joanne I. Hsu, Katie A. Matatall, Rebecca L. Murdaugh, Linda Zhang, Anna Guzman, Jack Toups, Daniel Hormaechea-Agulla, Carina Rosas, Meghan Kisiel, Ayumi Kitano, Tianyuan Hu, Yu-Jung Tseng, Bailee N. Kain, Sara Biesiadny, Jonathan Tiessen, Minhua Li, Marcus Florez, Sarah Waldvogel, Kristen Kurtz, Mira Jeong, Duy Le, Daniel E. Morales-Mantilla, Hannah Yan, Alejandra Garcia Martell, Chiraag D. Kapadia, Yung-Hsin Huang, Shannon E. Conneely, Rogelio Aguilar, Xiangguo Shi, Tianpeng Gu, Hyojeong Han, Yajian Jiang, Jason Rogers, Taishi Yonezawa, Apoorva Thatavarty, Ruoqiong Cao, Trisha K. Wathan, Nesa Mercer, Daniel Kennedy, Ayala Tovy, Jaime M. Reyes, Marek Kimmel, Yun Huang, Daisuke Nakada, Katherine Y. King, Margaret A. Goodell
Publikováno v:
Blood. 140:8590-8591
Autor:
Rui Chen, Kevin A. Hoegenauer, Xiangguo Shi, Daisuke Nakada, Ayumi Kitano, Rebecca Murdaugh, Koichi Takahashi, Yuan Li, Yajian Jiang, Tianyuan Hu
Publikováno v:
Science Advances
Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis in AML stem cells by suppressing p53.
Metabolic dysregulation underlies malignant phenotypes attributed to cancer stem cells, such as unlimited proliferation and differentiation bloc
Metabolic dysregulation underlies malignant phenotypes attributed to cancer stem cells, such as unlimited proliferation and differentiation bloc
Autor:
Kevin A. Hoegenauer, Brian Dawson, Tianyuan Hu, Victor Luu, Ayumi Kitano, Brendan Lee, Daisuke Nakada
Publikováno v:
Stem Cell Reports, Vol 13, Iss 3, Pp 545-558 (2019)
Stem Cell Reports
Stem Cell Reports
Summary Bone marrow stromal cells (BMSCs) that express high levels of stem cell factor (SCF) and CXC chemokine ligand 12 (CXCL12) are one crucial component of the hematopoietic stem cell (HSC) niche. While the secreted factors produced by BMSCs to su
Autor:
Kiyomi Morita, Koichi Takahashi, Yajian Jiang, Tianyuan Hu, Matthew C. Hill, Ayumi Kitano, Feng Wang, Xizeng Mao, Yusuke Saito, James F. Martin, Kevin A. Hoegenauer, P. Andrew Futreal, Daisuke Nakada, Kazuhiro Morishita
Publikováno v:
Blood
Oncogenic mutations confer on cells the ability to propagate indefinitely, but whether oncogenes alter the cell fate of these cells is unknown. Here, we show that the transcriptional regulator PRDM16s causes oncogenic fate conversion by transforming