Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Ayumi HASEGAWA"'
Autor:
Michiko Hirose, Kimiko Inoue, Shogo Matoba, Takaki Tatebe, Syun Tokita, Yukiko Dodo, Toshiko Tomishima, Ayumi Hasegawa, Arata Honda, Mao Ozaki, Akiko Shinogi, Ryoko Yanagisawa, Muhammad Fauzi, Takaaki Murakami, Nobuya Inagaki, Masaru Tamura, Atsuo Ogura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Because of the advent of genome-editing technology, gene knockout (KO) hamsters have become attractive research models for diverse diseases in humans. This study established a new KO model of diabetes by disrupting the insulin receptor subst
Externí odkaz:
https://doaj.org/article/01d7ed5f92ba44c797b3c246c9dc6450
Autor:
Keiji Mochida, Kohtaro Morita, Yoshio Sasaoka, Kento Morita, Hitoshi Endo, Ayumi Hasegawa, Masahide Asano, Atsuo Ogura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Rats are multiparous rodents that have been used extensively in research; however, the low reproductive performance of some rat strains hampers the broader use of rats as a biomedical model. In this study, the possibility of increasing the l
Externí odkaz:
https://doaj.org/article/34a4c487644244eaa395e176efe318de
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Wild-derived mouse strains have been extensively used in biomedical research because of the high level of inter-strain polymorphisms and phenotypic variations. However, they often show poor reproductive performance and are difficult to maint
Externí odkaz:
https://doaj.org/article/8ff3cfc8979e4199a96d2e0be871d59e
Autor:
Erika HAYASHI, Sayaka WAKAYAMA, Daiyu ITO, Ayumi HASEGAWA, Keiji MOCHIDA, Masatoshi OOGA, Atsuo OGURA, Teruhiko WAKAYAMA
Publikováno v:
The Journal of Reproduction and Development, Vol 68, Iss 2, Pp 118-124 (2022)
Mammalian embryos are most commonly cryopreserved in liquid nitrogen; however, liquid nitrogen is not available in special environments, such as the International Space Station (ISS), and vitrified embryos must be stored at −80°C. Recently, the hi
Externí odkaz:
https://doaj.org/article/f87a18adb9764d4a96fb8d8d79088e4e
Autor:
Keiji Mochida, Ayumi Hasegawa, Daiki Shikata, Nobuhiko Itami, Masashi Hada, Naomi Watanabe, Toshiko Tomishima, Atsuo Ogura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cryopreservation of mouse spermatozoa is widely used for the efficient preservation and safe transport of valuable mouse strains. However, the current cryopreservation method requires special containers (plastic straws), undefined chemicals
Externí odkaz:
https://doaj.org/article/bc39811397874fd4bcdd714e9d6a1b3d
Autor:
Sayaka Wakayama, Mariko Soejima, Yasuyuki Kikuchi, Erika Hayashi, Natsuki Ushigome, Ayumi Hasegawa, Keiji Mochida, Tomomi Suzuki, Chiaki Yamazaki, Toru Shimazu, Hiromi Sano, Masumi Umehara, Hitomi Matsunari, Atsuo Ogura, Hiroshi Nagashima, Teruhiko Wakayama
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0270781 (2022)
Whether mammalian embryos develop normally under microgravity remains to be determined. However, embryos are too small to be handled by inexperienced astronauts who orbit Earth on the International Space Station (ISS). Here we describe the developmen
Externí odkaz:
https://doaj.org/article/f7f5968922454a6587c4e096f421cb29
Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
Autor:
Kimiko Inoue, Narumi Ogonuki, Satoshi Kamimura, Hiroki Inoue, Shogo Matoba, Michiko Hirose, Arata Honda, Kento Miura, Masashi Hada, Ayumi Hasegawa, Naomi Watanabe, Yukiko Dodo, Keiji Mochida, Atsuo Ogura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.
Externí odkaz:
https://doaj.org/article/9a90abcae67c4e6d8be26b81b3d9af93
Publikováno v:
The Journal of Reproduction and Development, Vol 65, Iss 5, Pp 467-473 (2019)
Mature male mice (aged 10–12 weeks or older) are conventionally used for in vitro fertilization (IVF) in order to achieve high fertilization rates (e.g., > 70%). Here, we sought to determine the earliest age at which male mice (C57BL/6J strain) can
Externí odkaz:
https://doaj.org/article/84ffeadd202e488ca594f31f55f86d6d
Autor:
Kimiko Inoue, Michiko Hirose, Hiroki Inoue, Yuki Hatanaka, Arata Honda, Ayumi Hasegawa, Keiji Mochida, Atsuo Ogura
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 949-956 (2017)
Summary: MicroRNAs (miRNAs) represent small noncoding RNAs that are involved in physiological and developmental processes by posttranscriptionally inhibiting gene expression. One of the largest miRNA clusters in mice is located in intron 10 of the Sf
Externí odkaz:
https://doaj.org/article/7a8b55441fb849a0a957d0a8824ad509
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 12, Iss 3, Pp 16-00267-16-00267 (2017)
Bone tissue is a composite structure of apatite particles distributed in collagen fibril matrix on a nano-size scale. Mechanical properties of cortical bone are determined by the apatite-collagen composition. The amount and specific orientation of ap
Externí odkaz:
https://doaj.org/article/3ad618cbc3c24916b10637e44ca87540