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Akademický článek

The effect of advanced glycation end products on cellular signaling molecules in skeletal muscle

Autor: Tatsuro Egawa, Yoshitaka Ohno, Shingo Yokoyama, Ayumi Goto, Rika Ito, Tatsuya Hayashi, Katsumasa Goto

Publikováno v: Journal of Physical Fitness and Sports Medicine, Vol 7, Iss 4, Pp 229-238 (2018)

The accumulation of advanced glycation end products (AGEs) in the body causes the pathogenesis of aging-related diseases by inhibiting the normal properties and functions of proteins and the modulation of cellular signal transduction. Glycation stres

Externí odkaz: https://doaj.org/article/a6647d6600a84c449b0d246d2bacbf3b

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Akademický článek

The effect of short-term heat stress on protein synthesis signaling in isolated rat skeletal muscle

Autor: Ayumi Goto, Keiichi Sekine, Rieko Oshima, Ichika Sakon, Mayu Iwamoto, Tomohiko Osaki, Kotaro Haga, Tatsuya Hayashi, Tatsuro Egawa

Publikováno v: Journal of Physical Fitness and Sports Medicine, Vol 7, Iss 1, Pp 87-93 (2018)

Heat stress (HS) is a potent stimulus for activating glucose metabolism in skeletal muscles. However, the effect of short-term HS on protein turnover in skeletal muscles is unclear. This study aimed to investigate the effect of short-term HS on prote

Externí odkaz: https://doaj.org/article/678e4f53d11b41db80f1734cc2bcad62

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Akademický článek

Activation of adiponectin receptors has negative impact on muscle mass in C2C12 myotubes and fast-type mouse skeletal muscle.

Autor: Rika Ito, Masaki Higa, Ayumi Goto, Megumi Aoshima, Akihiro Ikuta, Kazuya Ohashi, Shingo Yokoyama, Yoshitaka Ohno, Tatsuro Egawa, Hirofumi Miyata, Katsumasa Goto

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0205645 (2018)

This study investigated the effects of AdipoRon, which is an agonist for adiponectin receptor 1 (AdipoR1) and AdipoR2, on the protein content, myotube diameter, and number of nuclei per myotube of C2C12 cells and skeletal muscle mass in C57BL/6J mice

Externí odkaz: https://doaj.org/article/5b49abfca3f64a95847ba4a4cc97994c

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Akademický článek

Some aspects of heat stress on the plasticity of skeletal muscle cells

Autor: Katsumasa Goto, Yoshitaka Ohno, Ayumi Goto, Akihiro Ikuta, Miho Suzuki, Tomotaka Ohira, Noriko Tsuchiya, Sono Nishizawa, Tomoyuki Koya, Tatsuro Egawa, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka

Publikováno v: Journal of Physical Fitness and Sports Medicine, Vol 1, Iss 2, Pp 197-204 (2012)

Hypertrophic stimuli, such as strength training and exercise, induce the up-regulation of heat shock proteins (HSPs), called stress proteins, in skeletal muscles. However, the physiological roles for induction of HSPs in skeletal muscles are still no

Externí odkaz: https://doaj.org/article/a8cba5a2675c410eba7e58fcdc330ee5

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Akademický článek

Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle.

Autor: Tomoyuki Koya, Sono Nishizawa, Yoshitaka Ohno, Ayumi Goto, Akihiro Ikuta, Miho Suzuki, Tomotaka Ohira, Tatsuro Egawa, Akira Nakai, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Moroe Beppu, Katsumasa Goto

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77788 (2013)

Hypertrophic stimuli, such as mechanical stress and overloading, induce stress response, which is mediated by heat shock transcription factor 1 (HSF1), and up-regulate heat shock proteins (HSPs) in mammalian skeletal muscles. Therefore, HSF1-associat

Externí odkaz: https://doaj.org/article/90b32974e9c94f95ac18ac62a1c1899d

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Akademický článek

Up-regulation of adiponectin expression in antigravitational soleus muscle in response to unloading followed by reloading, and functional overloading in mice.

Autor: Ayumi Goto, Yoshitaka Ohno, Akihiro Ikuta, Miho Suzuki, Tomotaka Ohira, Tatsuro Egawa, Takao Sugiura, Toshitada Yoshioka, Yoshinobu Ohira, Katsumasa Goto

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e81929 (2013)

The purpose of this study was to investigate the expression level of adiponectin and its related molecules in hypertrophied and atrophied skeletal muscle in mice. The expression was also evaluated in C2C12 myoblasts and myotubes. Both mRNA and protei

Externí odkaz: https://doaj.org/article/7fc7930424ee40fc9630bb7361ca4874

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