Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Aytug K Kiper"'
Autor:
Niels Decher, Beatriz Ortiz‐Bonnin, Corinna Friedrich, Marcus Schewe, Aytug K Kiper, Susanne Rinné, Gunnar Seemann, Rémi Peyronnet, Sven Zumhagen, Daniel Bustos, Jens Kockskämper, Peter Kohl, Steffen Just, Wendy González, Thomas Baukrowitz, Birgit Stallmeyer, Eric Schulze‐Bahr
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 4, Pp 403-414 (2017)
Abstract In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch‐activated K2P potassium channel TREK‐1 (KCNK2 or K2P2.1). This mutation introduces
Externí odkaz:
https://doaj.org/article/9640f01ff7df45b1a9d350a18cebee9f
Autor:
Susanne Rinné, Aytug K Kiper, Kirsty S Vowinkel, David Ramírez, Marcus Schewe, Mauricio Bedoya, Diana Aser, Isabella Gensler, Michael F Netter, Phillip J Stansfeld, Thomas Baukrowitz, Wendy Gonzalez, Niels Decher
Publikováno v:
eLife, Vol 8 (2019)
Two-pore-domain potassium (K2P) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of selective blockers, since drugs prefere
Externí odkaz:
https://doaj.org/article/9178c14d8086419a86795f2382cf020d
Autor:
Corinna Friedrich, Susanne Rinné, Sven Zumhagen, Aytug K Kiper, Nicole Silbernagel, Michael F Netter, Birgit Stallmeyer, Eric Schulze‐Bahr, Niels Decher
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 7, Pp 937-951 (2014)
Abstract Analyzing a patient with progressive and severe cardiac conduction disorder combined with idiopathic ventricular fibrillation (IVF), we identified a splice site mutation in the sodium channel gene SCN5A. Due to the severe phenotype, we perfo
Externí odkaz:
https://doaj.org/article/138f656725774f4ebb85eeb5736a7a6d
Autor:
Konstantin eWemhöner, Tatyana eKanyshkova, Nicole eSilbernagel, Juncal eFernandez-Orth, Stefan eBittner, Aytug K Kiper, Susanne eRinné, Michael F Netter, Sven G Meuth, Thomas eBudde, Niels eDecher
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 8 (2015)
Rats of the Wistar Albino Glaxo/Rij (WAG/Rij) strain show symptoms resembling human absence epilepsy. Thalamocortical neurons of WAG/Rij rats are characterized by an increased HCN1 expression, a negative shift in Ih activation curve, and an altered r
Externí odkaz:
https://doaj.org/article/f4e0e7c3ac26435a9350794f3ba87cb5
Autor:
Julian Alexander Schreiber, Anastasia Derksen, Gunnar Goerges, Sven Schütte, Jasmin Sörgel, Aytug K. Kiper, Nathalie Strutz-Seebohm, Tobias Ruck, Sven G. Meuth, Niels Decher, Guiscard Seebohm
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract The TWIK-related spinal cord K + channel (TRESK, K2P18.1) is a K2P channel contributing to the maintenance of membrane potentials in various cells. Recently, physiological TRESK function was identified as a key player in T-cell differentiati
Externí odkaz:
https://doaj.org/article/cd1204a78c1b47188a3f54d455330200
Autor:
Hauke Fender, Kim Walter, Aytug K. Kiper, Jelena Plačkić, Theresa M. Kisko, Moria D. Braun, Rainer K. W. Schwarting, Susanne Rohrbach, Markus Wöhr, Niels Decher, Jens Kockskämper
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9795 (2023)
CACNA1C encodes the pore-forming α1C subunit of the L-type Ca2+ channel, Cav1.2. Mutations and polymorphisms of the gene are associated with neuropsychiatric and cardiac disease. Haploinsufficient Cacna1c+/− rats represent a recently developed mod
Externí odkaz:
https://doaj.org/article/d9f78659843d41f8b4d58c8056c80183
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss S3, Pp 87-107 (2021)
Externí odkaz:
https://doaj.org/article/13bb2fb2883b4813a12778fd77c3e0c9
Autor:
Kockskämper, Hauke Fender, Kim Walter, Aytug K. Kiper, Jelena Plačkić, Theresa M. Kisko, Moria D. Braun, Rainer K. W. Schwarting, Susanne Rohrbach, Markus Wöhr, Niels Decher, Jens
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9795
CACNA1C encodes the pore-forming α1C subunit of the L-type Ca2+ channel, Cav1.2. Mutations and polymorphisms of the gene are associated with neuropsychiatric and cardiac disease. Haploinsufficient Cacna1c+/− rats represent a recently developed mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::0273897fa27149038c8f7ab55c35a751
Autor:
David Ramírez, Melissa Mejia-Gutierrez, Braulio Insuasty, Susanne Rinné, Aytug K. Kiper, Magdalena Platzk, Thomas Müller, Niels Decher, Jairo Quiroga, Pedro De-la-Torre, Wendy González
Publikováno v:
Molecules, Vol 26, Iss 13, p 3897 (2021)
TASK channels belong to the two-pore-domain potassium (K2P) channels subfamily. These channels modulate cellular excitability, input resistance, and response to synaptic stimulation. TASK-channel inhibition led to membrane depolarization. TASK-3 is e
Externí odkaz:
https://doaj.org/article/b948b1053c2845bcb1da099fd28e8efc
Autor:
Bárbara Arévalo, Mauricio Bedoya, Aytug K. Kiper, Fernando Vergara, David Ramírez, Yuliet Mazola, Daniel Bustos, Rafael Zúñiga, Rocio Cikutovic, Angel Cayo, Susanne Rinné, M. Teresa Ramirez-Apan, Francisco V. Sepúlveda, Oscar Cerda, Eduardo López-Collazo, Niels Decher, Leandro Zúñiga, Margarita Gutierrez, Wendy González
Publikováno v:
Journal of medicinal chemistry. 65(22)
Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. These compounds block TASK-1 channels by bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443847c04aa0a95094aa8f52a2e9c2ee
https://pubmed.ncbi.nlm.nih.gov/36378530
https://pubmed.ncbi.nlm.nih.gov/36378530