Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Aytug K, Kiper"'
Autor:
Lea C. Neelsen, Elena B. Riel, Susanne Rinné, Freya-Rebecca Schmid, Björn C. Jürs, Mauricio Bedoya, Jan P. Langer, Bisher Eymsh, Aytug K. Kiper, Sönke Cordeiro, Niels Decher, Thomas Baukrowitz, Marcus Schewe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Two-pore domain K+ (K2P) channel activity was previously thought to be controlled primarily via a selectivity filter (SF) gate. However, recent crystal structures of TASK-1 and TASK-2 revealed a lower gate at the cytoplasmic pore entrance. H
Externí odkaz:
https://doaj.org/article/24e90c44b7b6404d984bf10fe4b40d18
Autor:
Susanne Rinné, Florian Schick, Kirsty Vowinkel, Sven Schütte, Cornelius Krasel, Silke Kauferstein, Martin K.-H. Schäfer, Aytug K. Kiper, Thomas Müller, Niels Decher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract TASK-5 (KCNK15) belongs to the acid-sensitive subfamily of two-pore domain potassium (K2P) channels, which includes TASK-1 and TASK-3. TASK-5 stands out as K2P channel for which there is no functional data available, since it was reported in
Externí odkaz:
https://doaj.org/article/b17c857dbfc94fcaa4432f3f85b28b22
Autor:
Susanne Rinné, Aytug K. Kiper, Ralf Jacob, Beatriz Ortiz-Bonnin, Roland F.R. Schindler, Sabine Fischer, Marlene Komadowski, Emilia De Martino, Martin K.-H. Schäfer, Tamina Cornelius, Larissa Fabritz, Christian S.M. Helker, Thomas Brand, Niels Decher
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109696- (2024)
Summary: Popeye domain containing (POPDC) proteins are predominantly expressed in the heart and skeletal muscle, modulating the K2P potassium channel TREK-1 in a cAMP-dependent manner. POPDC1 and POPDC2 variants cause cardiac conduction disorders wit
Externí odkaz:
https://doaj.org/article/1ce96870dcd649eb8224595e7a24a264
Autor:
Julian Alexander Schreiber, Anastasia Derksen, Gunnar Goerges, Sven Schütte, Jasmin Sörgel, Aytug K. Kiper, Nathalie Strutz-Seebohm, Tobias Ruck, Sven G. Meuth, Niels Decher, Guiscard Seebohm
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract The TWIK-related spinal cord K + channel (TRESK, K2P18.1) is a K2P channel contributing to the maintenance of membrane potentials in various cells. Recently, physiological TRESK function was identified as a key player in T-cell differentiati
Externí odkaz:
https://doaj.org/article/cd1204a78c1b47188a3f54d455330200
Autor:
Lina A. Matschke, Marlene A. Komadowski, Annette Stöhr, Bolam Lee, Martin T. Henrich, Markus Griesbach, Susanne Rinné, Fanni F. Geibl, Wei-Hua Chiu, James B. Koprich, Jonathan M. Brotchie, Aytug K. Kiper, Amalia M. Dolga, Wolfgang H. Oertel, Niels Decher
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Parkinson’s disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta (SNpc). While SNpc neurons serve as
Externí odkaz:
https://doaj.org/article/b4c64fe5027f4227873cb7742ebf70c7
Autor:
Hauke Fender, Kim Walter, Aytug K. Kiper, Jelena Plačkić, Theresa M. Kisko, Moria D. Braun, Rainer K. W. Schwarting, Susanne Rohrbach, Markus Wöhr, Niels Decher, Jens Kockskämper
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9795 (2023)
CACNA1C encodes the pore-forming α1C subunit of the L-type Ca2+ channel, Cav1.2. Mutations and polymorphisms of the gene are associated with neuropsychiatric and cardiac disease. Haploinsufficient Cacna1c+/− rats represent a recently developed mod
Externí odkaz:
https://doaj.org/article/d9f78659843d41f8b4d58c8056c80183
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss S3, Pp 87-107 (2021)
Externí odkaz:
https://doaj.org/article/13bb2fb2883b4813a12778fd77c3e0c9
Autor:
Alejandro Valdés-Jiménez, Daniel Jiménez-González, Aytug K. Kiper, Susanne Rinné, Niels Decher, Wendy González, Miguel Reyes-Parada, Gabriel Núñez-Vivanco
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. Also, it would be a reasonable first step for the design of no
Externí odkaz:
https://doaj.org/article/197170dac86541658f2b64ec95dd9c6f
Autor:
Felix Wiedmann, Aytug K. Kiper, Mauricio Bedoya, Antonius Ratte, Susanne Rinné, Manuel Kraft, Maximilian Waibel, Priya Anad, Wolfgang Wenzel, Wendy González, Hugo A. Katus, Niels Decher, Constanze Schmidt
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 5, Pp 1223-1235 (2019)
Externí odkaz:
https://doaj.org/article/e40663fa70fb439ab236117496184d8c
Autor:
Kockskämper, Hauke Fender, Kim Walter, Aytug K. Kiper, Jelena Plačkić, Theresa M. Kisko, Moria D. Braun, Rainer K. W. Schwarting, Susanne Rohrbach, Markus Wöhr, Niels Decher, Jens
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9795
CACNA1C encodes the pore-forming α1C subunit of the L-type Ca2+ channel, Cav1.2. Mutations and polymorphisms of the gene are associated with neuropsychiatric and cardiac disease. Haploinsufficient Cacna1c+/− rats represent a recently developed mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::0273897fa27149038c8f7ab55c35a751