Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aysun Çapcı Karagöz"'
Autor:
Oliver Friedrich, Manfred Marschall, Maria Leidenberger, Frank Hampel, Friedrich Hahn, Aysun Çapcı Karagöz, Svetlana B. Tsogoeva, Barbara Kappes
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:110-115
Severe malaria and viral infections cause life-threatening diseases in millions of people worldwide every year. In search for effective bioactive hybrid molecules, which may possess improved properties compared to their parent compounds, a series of
Autor:
Barbara Kappes, Lisa Gruber, Aysun Çapcı Karagöz, Thomas Efferth, Oliver Friedrich, Svetlana B. Tsogoeva, Christoph Reiter, Ean-Jeong Seo, Frank Hampel, Maria Leidenberger, Friedrich Hahn, Volker Klein, Manfred Marschall
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:3610-3618
Hybridization of natural products has high potential to further improve their activities and may produce synergistic effects between linked pharmacophores. Here we report synthesis of nine new hybrids of natural products egonol, homoegonol, thymoquin
Autor:
Michael Buchfelder, Annemarie Ackermann, Svetlana B. Tsogoeva, Aysun Çapcı Karagöz, Ilker Y. Eyüpoglu, Nicolai E. Savaskan, Ali Ghoochani
Publikováno v:
Oncotarget
Gliomas are brain-born tumors with devastating impact on their brain microenvironment. Novel approaches employ multiple combinations of chemical compounds in synthetic hybrid molecules to target malignant tumors. Here, we report on the chemical hybri
Publikováno v:
Synthesis. 49:29-41
Click chemistry is one of the most efficient and widely used methodologies for selective C–N bond forming reactions, encompassing the synthesis of 1,2,3-triazoles, and it has been continued to be of great interest in synthetic and medicinal chemist
Publikováno v:
Journal of Medicinal Chemistry. 59:7360-7388
The development of new efficient therapeutics for the treatment of malaria and cancer is an important endeavor. Over the past 15 years, much attention has been paid to the synthesis of dimeric structures, which combine two units of artemisinin, as le
Autor:
Regine Schneider-Stock, Hala Gali-Muhtasib, Pithi Chanvorachote, Benardina Ndreshkjana, Chuanpit Ninsontia, Aysun Çapcı Karagöz, Kerstin Huebner, Maamoun Fatfat, Volker Klein, Abbas Agaimy, Julienne K. Muenzner, Sara Steinmann, Svetlana B. Tsogoeva
Publikováno v:
Cancer Research. 77:1904-1904
Objectives: Recently, it has been shown that a subset population of cancer cells in a tumor, the so-called cancer stem cells (CSCs), majorly contributes to chemoresistance and the ability of a tumor to form recurrences and metastases. Since the respo
Autor:
Aysun Çapcı-Karagöz, Tamer Karayildirim, Ali Özmen, Esin Poyrazoğlu-Çoban, Safiye Emirdağ-Öztürk, Özgen Alankuş-Çalışkan
Publikováno v:
European journal of medicinal chemistry. 82
A series of gypsogenin ( 1 ) derivatives ( 1a – i ) was synthesized in good yields, and the derivatives’ structures were established using UV, IR, 1 H NMR, 13 C NMR, and LCMS spectroscopic data. Among the tested compounds, 1a , 1b , 1d , 1e , and
Autor:
Benjamin Mordmüller, Aysun Çapcı Karagöz, Safiye Emirdağ Öztürk, Tony Fröhlich, Christoph Reiter, Jana Held, Volker Klein, Maen Zeino, Katrin Viertel, Hüseyin Anil, Svetlana B. Tsogoeva, Thomas Efferth
Publikováno v:
European journal of medicinal chemistry. 75
Malaria and cancer cause the death of millions of people every year. To combat these two diseases, it is important that new pharmaceutically active compounds have the ability to overcome multidrug resistance in cancer and Plasmodium falciparum strain