Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Aysegul Sapmaz"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/27687c22db5d4add8f673150f0642df9
Autor:
Bianca D. M. van Tol, Bjorn R. van Doodewaerd, Guinevere S. M. Lageveen-Kammeijer, Bas C. Jansen, Cami M. P. Talavera Ormeño, Paul J. M. Hekking, Aysegul Sapmaz, Robbert Q. Kim, Angeliki Moutsiopoulou, David Komander, Manfred Wuhrer, Gerbrand J. van der Heden van Noort, Huib Ovaa, Paul P. Geurink
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Most insights into deubiquitinase (DUB) substrate specificity originate from studies with isolated di-ubiquitins (diUb), but in cells diUbs with different linkage types coexist. Here, the authors develop a mass spectrometric DUB activity assay that c
Externí odkaz:
https://doaj.org/article/2c3b7930e79a4065a586ae1d307ad567
Autor:
Yara Huppelschoten, Jens Buchardt, Thomas E. Nielsen, Aysegul Sapmaz, Gerbrand J. van der Heden van Noort
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 884 (2023)
Autophagy is a conserved cellular process involved in the degradation of intercellular materials. During this process, double-membrane vesicles called autophagosomes engulf cytoplasmic components ready for degradation. A key component in the formatio
Externí odkaz:
https://doaj.org/article/b9f4b250732d484681a86fb0ef2bab79
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The ubiquitin-proteasome system is an essential regulator of many cellular processes including controlling protein homeostasis. The degradation of proteins by the multi-subunit proteasome complex is tightly regulated through a series of checkpoints,
Externí odkaz:
https://doaj.org/article/83f130954dfa41bc83cb7e8bca4d7fac
Autor:
Aysegul Sapmaz, Ilana Berlin, Erik Bos, Ruud H. Wijdeven, Hans Janssen, Rebecca Konietzny, Jimmy J. Akkermans, Ayse E. Erson-Bensan, Roman I. Koning, Benedikt M. Kessler, Jacques Neefjes, Huib Ovaa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Though ubiquitin is known to broadly influence endosomal trafficking, few ubiquitin-utilizing enzymes targeting endosomal regulators are known. Here, the authors find that the deubiquitylating enzyme (DUB) USP32 influences endosomal membrane dynamics
Externí odkaz:
https://doaj.org/article/03097ad9b5bc4f32abfc5298bf844d05
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Proteasomes are critical proteases in the cell responsible for the turnover of many cytoplasmic and nuclear proteins. They are essential for many cellular processes and various diseases are associated with their malfunctioning. Proteasome activity de
Externí odkaz:
https://doaj.org/article/12754d0f56b74b49ae44173cb373f46c
Autor:
Aysegul Sapmaz, Ayse Elif Erson-Bensan
Publikováno v:
Oncotarget. 14:297-301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a5533c55c7e14bd3ee772814c568e3
https://doi.org/10.18632/oncotarget.28400
https://doi.org/10.18632/oncotarget.28400
Publikováno v:
Journal of Cell Science, 136(4). COMPANY BIOLOGISTS LTD
The endolysosomal system comprises a dynamic constellation of vesicles working together to sense and interpret environmental cues and facilitate homeostasis. Integrating extracellular information with the internal affairs of the cell requires endosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c51622aa9c8761b40fa946d3301ccce
https://doi.org/10.1242/jcs.260101
https://doi.org/10.1242/jcs.260101
Publikováno v:
Journal of Medicinal Chemistry, 65(19), 13288-13304. AMER CHEMICAL SOC
The multifunctional human Parkinson's disease protein 7 (PARK7/DJ1) is an attractive therapeutic target due to its link with early-onset Parkinson's disease, upregulation in various cancers, and contribution to chemoresistance. However, only a few co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89387668ac6eb1240fdbc4a0fb656db3
https://hdl.handle.net/1887/3514348
https://hdl.handle.net/1887/3514348
Autor:
Ozgur Sahin, Rengul Cetin-Atalay, Sezen Guntekin Ergun, Esra Cicek, Didem Naz Dioken, Merve Oyken, Ayca Circir, Huib Ovaa, Ayse Elif Erson-Bensan, Ozge Akbulut Caliskan, Aysegul Sapmaz
Publikováno v:
Oncogene
Oncogene, 41, 220-232. SPRINGERNATURE
Oncogene, 41, 220-232. SPRINGERNATURE
Epidermal growth factor receptor (EGFR) has critical roles in epithelial cell physiology. Over-expression and over-activation of EGFR have been implicated in diverse cancers, including triple-negative breast cancers (TNBCs), prompting anti-EGFR thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542c0a7ff0088f602198d09cc55969db
https://aperta.ulakbim.gov.tr/record/237572
https://aperta.ulakbim.gov.tr/record/237572