Transcriptional profiling in microglia across physiological and pathological states identifies a transcriptional module associated with neurodegeneration

Autor: Aysegul Guvenek, Neelroop Parikshak, Daria Zamolodchikov, Sahar Gelfman, Arden Moscati, Lee Dobbyn, Eli Stahl, Alan Shuldiner, Giovanni Coppola

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)

Abstract Microglia are the resident immune cells of the central nervous system and are involved in brain development, homeostasis, and disease. New imaging and genomics technologies are revealing microglial complexity across developmental and functio

Externí odkaz: https://doaj.org/article/db54ef0641f24ba999c630d873047935

The relationship between vitamin D, asthma and total IgE in children

Autor: Ali Unsal Yozgatli, Faruk Akçay, Handan Türkan Tuna, Nimet Pinar Yilmazbas, Aysegul Uslu, Eylem Erzurumlu, Aysegul Guven, Gulsen Meral

Publikováno v: Studies on Ethno-Medicine. 11:91-97

Current researches have pointed out that vitamin D may play a role in multiple chronic illnesses, including symptoms involving the respiratory system. This study evaluated the interaction between v...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5e649fa5edc3b44e736a14095f9bc49
https://doi.org/10.1080/09735070.2017.1311697

PMS2CL interference leading to erroneous identification of a pathogenic PMS2 variant in Black patients

Autor: Jacqueline Cappadocia, Lisa B. Aiello, Michael J. Kelley, Bryson W. Katona, Kara N. Maxwell, Anurag Verma, Ph.D., Shefali S. Verma, Ph.D., Yuki Bradford, M.S., Ashlei Brock, Stephanie DerOhannessian, Scott Dudek, M.S., Joseph Dunn, Theodore Drivas, M.D., Ph.D., Ned Haubein, Khadijah Hu-Sain, Renae Judy, Ashley Kloter, Yi-An Ko, Meghan Livingstone, Linda Morrel, Colleen Morse, M.S., Afiya Poindexter, Marjorie Risman, M.S., Teo Tran, Fred Vadivieso, JoEllen Weaver, Daniel J. Rader, M.D., Marylyn D. Ritchie, Ph.D., Michael D. Feldman, M.D., Ph.D., Christina Beechert, Caitlin Forsythe, M.S., Erin D. Fuller, Zhenhua Gu, M.S., Michael Lattari, Alexander Lopez, M.S., John D. Overton, Ph.D., Maria Sotiropoulos Padilla, M.S., Manasi Pradhan, M.S., Kia Manoochehri, B.S., Thomas D. Schleicher, M.S., Louis Widom, Sarah E. Wolf, M.S., Ricardo H. Ulloa, B.S., Amelia Averitt, Ph.D., Nilanjana Banerjee, Ph.D., Michael Cantor, M.D., Dadong Li, Ph.D., Sameer Malhotra, M.D., Deepika Sharma, MHI, Jeffrey Staples, Ph.D., Xiaodong Bai, Ph.D., Suganthi Balasubramanian, Ph.D., Suying Bao, Ph.D., Boris Boutkov, Ph.D., Siying Chen, Ph.D., Gisu Eom, B.S., Lukas Habegger, Ph.D., Alicia Hawes, B.S., Shareef Khalid, Olga Krasheninina, M.S., Rouel Lanche, B.S., Adam J. Mansfield, B.A., Evan K. Maxwell, Ph.D., George Mitra, B.A., Mona Nafde, M.S., Sean O’Keeffe, Ph.D., Max Orelus, B.B.A., Razvan Panea, Ph.D., Tommy Polanco, B.A., Ayesha Rasool, M.S., Jeffrey G. Reid, Ph.D., William Salerno, Ph.D., Jeffrey C. Staples, Ph.D., Kathie Sun, Ph.D., Goncalo Abecasis, D.Phil., Joshua Backman, Ph.D., Amy Damask, Ph.D., Lee Dobbyn, Ph.D., Manuel Allen Revez Ferreira, Ph.D., Arkopravo Ghosh, M.S., Christopher Gillies, Ph.D., Lauren Gurski, B.S., Eric Jorgenson, Ph.D., Hyun Min Kang, Ph.D., Michael Kessler, Ph.D., Jack Kosmicki, Ph.D., Alexander Li, Ph.D., Nan Lin, Ph.D., Daren Liu, M.S., Adam Locke, Ph.D., Jonathan Marchini, Ph.D., Anthony Marcketta, M.S., Joelle Mbatchou, Ph.D., Arden Moscati, Ph.D., Charles Paulding, Ph.D., Carlo Sidore, Ph.D., Eli Stahl, Ph.D., Kyoko Watanabe, Ph.D., Bin Ye, Ph.D., Blair Zhang, Ph.D., Andrey Ziyatdinov, Ph.D., Ariane Ayer, B.S., Aysegul Guvenek, Ph.D., George Hindy, Ph.D., Giovanni Coppola, M.D., Jan Freudenberg, M.D., Jonas Bovijn, M.D., Katherine Siminovitch, M.D., Kavita Praveen, Ph.D., Luca A. Lotta, M.D., Manav Kapoor, Ph.D., Mary Haas, Ph.D., Moeen Riaz, Ph.D., Niek Verweij, Ph.D., Olukayode Sosina, Ph.D., Parsa Akbari, Ph.D., Priyanka Nakka, Ph.D., Sahar Gelfman, Ph.D., Sujit Gokhale, B.E., Tanima De, Ph.D., Veera Rajagopal, Ph.D., Alan Shuldiner, M.D., Gannie Tzoneva, Ph.D., Juan Rodriguez-Flores, Ph.D., Esteban Chen, M.S., Marcus B. Jones, Ph.D., Michelle G. LeBlanc, Ph.D., Jason Mighty, Ph.D., Lyndon J. Mitnaul, Ph.D., Nirupama Nishtala, Ph.D., Nadia Rana, Ph.D., Jaimee Hernandez, Goncalo Abecasis, PhD, Aris Baras, M.D., Andrew Deubler, Aris Economides, Ph.D., Luca A. Lotta, M.D., Ph.D.

Publikováno v: Genetics in Medicine Open, Vol 2, Iss , Pp 101858- (2024)

This study investigates the frequency of a clinically reported variant in PMS2, NM_000535.7:c.2523G>A p.(W841∗), from next-generation sequencing studies in 2 racially diverse cohorts. We identified clinical reports of the PMS2 c.2523G>A p.(W841∗)

Externí odkaz: https://doaj.org/article/208611a0067a41088e055b67156b197c

Is Vitamin D Deficiency Associated with Disbiosis in Bowel Flora?

Autor: Aysegul Guven, Faruk Akçay, Aysegul Uslu, Pinar Yaprak, Gulsen Meral, Gamze Can, Ali Unsal Yozgatli

Publikováno v: Studies on Ethno-Medicine. 10:71-75

This retrospective study aimed to assess the increase in vitamin D levels after treatment of children with deficiencies of this vitamin diagnosed at Kagithane State Hospital ospital in winter and s...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67ccbf8d976aba9812170f24c703a491
https://doi.org/10.1080/09735070.2016.11905474

Neuronal Cells Display Distinct Stability Controls of Alternative Polyadenylation mRNA Isoforms, Long Non-Coding RNAs, and Mitochondrial RNAs

Autor: Aysegul Guvenek, Jihae Shin, Lidia De Filippis, Dinghai Zheng, Wei Wang, Zhiping P. Pang, Bin Tian

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

RNA stability plays an important role in gene expression. Here, using 3′ end sequencing of newly made and pre-existing poly(A)+ RNAs, we compare transcript stability in multiple human cell lines, including HEK293T, HepG2, and SH-SY5Y. We show that

Externí odkaz: https://doaj.org/article/1f93110956ac4d3e99093c2f735deb9c