Výsledky vyhledávání - "Ayse Nihal, Sari"

Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl‐3‐(1‐propionylpiperidin‐4‐yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome‐related pro‐inflammatory and anti‐inflammatory signaling pathways in the lipopolysaccharide‐induced pain mouse model

Autor: Seyhan Sahan-Firat, Ali Cagli, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Bahar Tunctan, Ayse Nihal Sari, Demet Sinem Guden

Publikováno v: Drug Development Research. 82:815-825

Epoxyeicosatrienoic acids (EETs) have anti-inflammatory effects and soluble epoxide hydrolase (sEH) inhibition might be a useful therapeutic approach to manage inflammatory disorders. The purpose of the study was to investigate whether nucleotide-bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d45be6a2feb52e9d6be516661c71a72
https://doi.org/10.1002/ddr.21786

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Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model

Autor: Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Sefika Pinar Senol, Demet Sinem Guden, Ayse Nihal Sari, Bahar Tunctan

Publikováno v: Neurochemical Research. 46:624-637

A selective RXR agonist, bexarotene, has been shown to have anti-inflammatory, anti-nociceptive, and neuroprotective effects in several models of numerous neurological diseases characterized by systemic inflammation. The mechanisms underlying these e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1fa0bb65e17f1828235b1c72b3804d
https://doi.org/10.1007/s11064-020-03197-7

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Activation of GPR75 Signaling Pathway Contributes to the Effect of a 20-HETE Mimetic, 5,14-HEDGE, to Prevent Hypotensive and Tachycardic Responses to Lipopolysaccharide in a Rat Model of Septic Shock

Autor: Bahar Tunctan, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Dilsah Ezgi Yilmaz, Demet Sinem Guden, Omer Bahceli, Mehmet Furkan Horat, Seyhan Sahan-Firat, Ayse Nihal Sari, John R. Falck, Raghunath Reddy Anugu, Kafait U. Malik

Publikováno v: Journal of cardiovascular pharmacology. 80(2)

The orphan receptor, G protein-coupled receptor (GPR) 75, which has been shown to mediate various effects of 20-hydroxyeicosatetraenoic acid (20-HETE), is considered as a therapeutic target in the treatment of cardiovascular diseases in which changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e7a8caeece3d61696c612a8e6217c7
https://pubmed.ncbi.nlm.nih.gov/35575984

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Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome-related pro-inflammatory and anti-inflammatory signaling pathways in the lipopolysaccharide-induced pain mouse model

Autor: Ali, Cagli, Sefika Pinar, Senol, Meryem, Temiz-Resitoglu, Demet Sinem, Guden, Ayse Nihal, Sari, Seyhan, Sahan-Firat, Bahar, Tunctan

Publikováno v: Drug development researchREFERENCES. 82(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c43497d064b3dfeb0816bcc57e095878
https://pubmed.ncbi.nlm.nih.gov/33559150

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Bexarotene, a Selective RXRα Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock

Autor: Seyhan Sahan-Firat, Meryem Temiz-Resitoglu, Sefika Pinar Kucukkavruk, Ayse Nihal Sari, Demet Sinem Guden, Bahar Tunctan

Publikováno v: Inflammation. 41:337-355

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that can activate or inhibit the expression of many target genes by forming a heterodimer complex with the retinoid X receptor (RXR). The aim of this study was to investigate e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5943df4819a1319bd3a0820d937aadd
https://doi.org/10.1007/s10753-017-0691-5

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NF-κB activation mediates LPS-or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock

Autor: Bahar Tunctan, Meryem Temiz-Resitoglu, Kafait U. Malik, Meltem Cil, Demet Sinem Guden, Belma Korkmaz, Cuneyt Kemal Buharalioglu, Seyhan Sahan-Firat, Ayse Nihal Sari, Demet Unsal, Sefika Pinar Senol

Publikováno v: Clinical and experimental pharmacologyphysiology. 46(2)

We have previously demonstrated that the activation of the spleen tyrosine kinase (Syk)/inhibitory-κB (IκB)-α/nuclear factor-κB (NF-κB) p65 signalling pathway contributes to hypotension and inflammatory response in a rat models of zymosan (ZYM)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d006a175b01636816ce4479c3434c0ba
https://pubmed.ncbi.nlm.nih.gov/30347478

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Protection by mTOR Inhibition on Zymosan-Induced Systemic Inflammatory Response and Oxidative/Nitrosative Stress: Contribution of mTOR/MEK1/ERK1/2/IKKβ/IκB-α/NF-κB Signalling Pathway

Autor: Zumrut Kocak, Bahar Tunctan, Demet Sinem Guden, Sefika Pinar Kucukkavruk, Ayse Nihal Sari, Kafait U. Malik, Seyhan Sahan-Firat, Meryem Temiz-Resitoglu

Publikováno v: Inflammation. 41(1)

Mammalian target of rapamycin (mTOR), a serine/threonine kinase regulate variety of cellular functions including cell growth, differentiation, cell survival, metabolism, and stress response, is now appreciated to be a central regulator of immune resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45f4b112adf5ad0debc002dc216b39a
https://pubmed.ncbi.nlm.nih.gov/29110153

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The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock

Autor: Meltem Kacan, Lulufer Tamer-Gumus, Demet Sinem Guden, Bahar Tunctan, Seyhan Sahan-Firat, Meryem Temiz-Resitoglu, Ayse Nihal Sari, Belma Korkmaz, Kafait U. Malik, Hatice Yildirim-Yaroglu, Cuneyt Kemal Buharalioglu, Demet Unsal

Publikováno v: Clinical and experimental pharmacologyphysiology. 45(2)

Summary Spleen tyrosine kinase (Syk), a non-receptor tyrosine kinase, plays an important role in allergic diseases and inflammation. Syk triggers several intracellular signalling cascades including Toll-like receptor signalling to activate inflammato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffa1fdc818e71356866c60d913ab21a
https://pubmed.ncbi.nlm.nih.gov/28949404

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Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats

Autor: Meryem Temiz-Resitoglu, Demet Sinem Guden, Seyhan Sahan-Firat, Lulufer Tamer-Gumus, Aysegul Gorur, Ayse Nihal Sari, Kafait U. Malik, Sefika Pinar Kucukkavruk, Cuneyt Kemal Buharalioglu, Pelin Cecen, Bahar Tunctan

Publikováno v: European journal of pharmacology. 802

Mammalian target of rapamycin (mTOR), a serine/threonine kinase plays an important role in various pathophysiological processes including cancer, metabolic diseases, and inflammation. Although mTOR participates in Toll-like receptor 4 signalling in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416257cfda939d0f9c502739a6b72768
https://pubmed.ncbi.nlm.nih.gov/28228357

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