Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

Autor: Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Oliver Ohlenschläger, Jordan D. Dimitrov, Hugo Mouquet

Publikováno v: Cell Reports, Vol 23, Iss 9, Pp 2568-2581 (2018)

Human high-affinity antibodies to pathogens often recognize unrelated ligands. The molecular origin and the role of this polyreactivity are largely unknown. Here, we report that HIV-1 broadly neutralizing antibodies (bNAbs) are frequently polyreactiv

Externí odkaz: https://doaj.org/article/94e93b8b4c694f2ab52f103c8961f5f0

Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection.

Autor: Mohammad-Ali Jenabian, Nabila Seddiki, Ahmad Yatim, Matthieu Carriere, Anne Hulin, Mehwish Younas, Elnaz Ghadimi, Ayrin Kök, Jean-Pierre Routy, Alain Tremblay, Jean Sévigny, Jean-Daniel Lelievre, Yves Levy

Publikováno v: PLoS Pathogens, Vol 9, Iss 4, p e1003319 (2013)

The mechanisms by which Regulatory T cells suppress IL-2 production of effector CD4+ T cells in pathological conditions are unclear. A subpopulation of human Treg expresses the ectoenzyme CD39, which in association with CD73 converts ATP/ADP/AMP to a

Externí odkaz: https://doaj.org/article/d25017a4d436445f9653e87fc9a16d22

Scarcity of autoreactive human blood IgA+ memory B cells

Autor: Hugo Mouquet, Ayrin Kök, Salomé Bourgeau, Valérie Lorin, Julie Prigent, Thierry Hieu

Publikováno v: European Journal of Immunology

Class-switched memory B cells are key components of the "reactive" humoral immunity, which ensures a fast and massive secretion of high-affinity antigen-specific antibodies upon antigenic challenge. In humans, IgA class-switched (IgA+ ) memory B cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a1a5996e726a6a727edebe39b67f10
http://europepmc.org/articles/PMC5113776

Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals

Autor: Valérie Lorin, Mathieu Surenaud, Cyril Planchais, Hugo Mouquet, Mathieu Fusaro, Sophie Hue, Marie-Hélène Delfau-Larue, Nabila Seddiki, Clara Ibanez, Laurent Hocqueloux, Michael J. Levy, Thierry Prazuck, S. Gallien, Yves Levy, Ayrin Kök, Christiane Copie, Jean-Daniel Lelièvre, Laurent Lefrou

Publikováno v: Journal of Immunology
Journal of Immunology, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩

HIV-1 infection is associated with B cell dysregulation and dysfunction. In HIV-1–infected patients, we previously reported preservation of intestinal lymphoid structures and dendritic cell maturation pathways after early combination antiretroviral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2622102e5901a8a1bf6c99603c6ba9c4
https://hal-pasteur.archives-ouvertes.fr/pasteur-02634634/document

A human immune system mouse model with robust lymph node development

Autor: Hugo Mouquet, Grégory Jouvion, Helene Strick-Marchand, Ai Ing Lim, Nicolas Serafini, Zacarias Garcia, Philippe Bousso, Yan Li, Daniela Finke, Olivier Schwartz, Timothée Bruel, Ayrin Kök, Franck Bourgade, Guillemette Masse-Ranson, Thierry Hieu, Antoine Toubert, Mathilde Dusséaux, James P. Di Santo

Publikováno v: Nature Methods
Nature Methods, Nature Publishing Group, 2018, 15 (8), pp.623-630. ⟨10.1038/s41592-018-0071-6⟩
Nature Methods, 2018, 15 (8), pp.623-630. ⟨10.1038/s41592-018-0071-6⟩

International audience; Lymph nodes (LNs) facilitate the cellular interactions that orchestrate immune responses. Human immune system (HIS) mice are powerful tools for interrogation of human immunity but lack secondary lymphoid tissue (SLT) as a resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152ed891295814431a971358f8be482b
https://pubmed.ncbi.nlm.nih.gov/30065374