Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ayrianne J. Crawford"'
Publikováno v:
Machines, Vol 10, Iss 8, p 697 (2022)
The ability to microscopically image diseased or damaged tissue throughout a longitudinal study in living mice would provide more insight into disease progression than having just a couple of time points to study. In vivo disease development and moni
Externí odkaz:
https://doaj.org/article/b0d1a485bc544b03ab22198709d3dfab
Autor:
Kamiya Mehla, Michael A. Hollingsworth, Elizabeth M. Jaffee, Jill A. Poole, Christopher F. Nicodemus, Manuel L. Penichet, Tracy R. Daniels-Wells, Ragupathy Madiyalakan, Pankaj K. Singh, Paul M. Grandgenett, Prakash Radhakrishnan, Kirsten C. Eberle, Ying Huang, Krysten E. Vance, Ayrianne J. Crawford, Daisy Gonzalez, Surendra K. Shukla, Prathamesh P. Patil, Ryan Hanson, Simon Shin, James A. Grunkemeyer, Kelly A. O'Connell, Thomas C. Caffrey, Spas Dimitrov Markov
Gating strategy for immune subsets in pancreatic tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3753305f8e07d448271a246292984a83
https://doi.org/10.1158/1535-7163.22522485
https://doi.org/10.1158/1535-7163.22522485
Autor:
Kelly A. O'Connell, Manuel L. Penichet, Ying Huang, Paul M. Grandgenett, Christopher F. Nicodemus, Pankaj K. Singh, Thomas C. Caffrey, Spas Dimitrov Markov, Jill A. Poole, Prakash Radhakrishnan, Prathamesh Patil, Daisy Gonzalez, Ayrianne J. Crawford, Elizabeth M. Jaffee, Tracy R. Daniels-Wells, Surendra K. Shukla, James A. Grunkemeyer, Kamiya Mehla, Ragupathy Madiyalakan, Simon C. Shin, Ryan Hanson, Krysten E. Vance, Michael A. Hollingsworth, Kirsten C. Eberle
Publikováno v:
Mol Cancer Ther
Pancreatic ductal adenocarcinoma (PDAC) represents 3% of all cancer cases and 7% of all cancer deaths in the United States. Late diagnosis and inadequate response to standard chemotherapies contribute to an unfavorable prognosis and an overall 5-year
Autor:
John Victor Napoleon, Satish Sagar, Sydney P. Kubica, Lidia Boghean, Smit Kour, Hannah M. King, Yogesh A. Sonawane, Ayrianne J. Crawford, Nagsen Gautam, Smitha Kizhake, Pawel A. Bialk, Eric Kmiec, Jayapal Reddy Mallareddy, Prathamesh P. Patil, Sandeep Rana, Sarbjit Singh, Janani Prahlad, Paul M. Grandgenett, Gloria E. O. Borgstahl, Gargi Ghosal, Yazen Alnouti, Michael A. Hollingsworth, Prakash Radhakrishnan, Amarnath Natarajan
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Activation of inhibitor of nuclear factor NF-κB kinase subunit-β (IKKβ), characterized by phosphorylation of activation loop serine residues 177 and 181, has been implicated in the early onset of cancer. On the other hand, tissue-specific IKKβ kn
Autor:
Michael A. Hollingsworth, Nicholas E. Wojtynek, Ayrianne J. Crawford, Geoffrey A. Talmon, Bowen Qi, Aaron M. Mohs, Quan P. Ly
Publikováno v:
Theranostics
The prognosis of pancreatic cancer remains poor. Intraoperative fluorescence imaging of tumors could improve staging and surgical resection, thereby improving prognosis. However, imaging pancreatic cancer with macromolecular delivery systems, is ofte
Autor:
Xu Luo, Michael A. Hollingsworth, Carter J. Barger, Smit Kour, Ayrianne J. Crawford, Smitha Kizhake, Jacob I. Contreras, Hannah M. King, Amarnath Natarajan, Caroline M. Robb, Mourad Bendjennat, Sandeep Rana, Yogesh A. Sonawane
Publikováno v:
Molecular Pharmacology
Developing small molecules that indirectly regulate Mcl-1 function has attracted a lot of attention in recent years. Here, we report the discovery of an aminopyrazole, 2-([1,1′-biphenyl]-4-yl)-N-(5-cyclobutyl-1H-pyrazol-3-yl)acetamide (analog 24),
Autor:
Prathamesh Patil, Thomas C. Caffrey, Michael A. Hollingsworth, Swetha Thiyagarajan, Ayrianne J. Crawford, Stefan Vetter, Estelle Leclerc, Tammi L Neville, Simon Shin, Priyanka Swami, James A. Grunkemeyer, Prakash Radhakrishnan, Kelly A. O'Connell
Publikováno v:
Biomolecules, Vol 11, Iss 526, p 526 (2021)
Biomolecules
Volume 11
Issue 4
Biomolecules
Volume 11
Issue 4
Pancreatic ductal adenocarcinoma (PDAC) remains a very difficult cancer to treat. Recent in vitro and in vivo studies suggest that the activation of the receptor for advanced glycation end products (RAGE) by its ligands stimulates pancreatic cancer c
Autor:
Richard Sleightholm, Veenu Bala, Michael A. Hollingsworth, Ayrianne J. Crawford, Daryl J. Murry, Yashpal S. Chhonker
Publikováno v:
Biomedical chromatography : BMCREFERENCES. 34(8)
A rapid, selective, and sensitive liquid chromatography coupled with tandem mass spectrometry (MS/MS) method was developed and validated for the quantitation of the novel CDK5 inhibitor '20-223' in mouse plasma. Separation of analytes was achieved by
Autor:
Michael A. Hollingsworth, Jared Baxter, Sandeep Rana, Caroline M. Robb, Yogesh A. Sonawane, Smit Kour, Ayrianne J. Crawford, Xu Luo, Smitha Kizhake, Jacob I. Contreras, Amarnath Natarajan, Hannah M. King
Publikováno v:
ACS Chemical Biology. 13:1148-1152
The study presented here provides a framework for the discovery of unique inhibitor combinations that target the apoptosis network for cancer therapy. A pair of doxycycline (Dox) -inducible cell lines that specifically report on the ability of an inh
Autor:
Joshua J. Souchek, Samuel M. Cohen, Michael A. Hollingsworth, Nicholas E. Wojtynek, Bowen Qi, Aaron M. Mohs, Quan P. Ly, Megan B. Holmes, Graça Almeida-Porada, Ayrianne J. Crawford
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 14:769-780
Pancreatic ductal adenocarcinoma is highly lethal and surgical resection is the only potential curative treatment for the disease. In this study, hyaluronic acid derived nanoparticles with physico-chemically entrapped indocyanine green, termed NanoIC