Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ayrea Hurley"'
Autor:
Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R. Tanner, Rong-Chi Hu, Michael W. Pennington, William R. Lagor, Christine Beeton
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. S
Externí odkaz:
https://doaj.org/article/ca2fd58e706445a2b6b685c437aebfe2
Autor:
Marco De Giorgi, Ang Li, Ayrea Hurley, Mercedes Barzi, Alexandria M. Doerfler, Nikitha A. Cherayil, Harrison E. Smith, Jonathan D. Brown, Charles Y. Lin, Karl-Dimiter Bissig, Gang Bao, William R. Lagor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 656-669 (2021)
Clinical application of somatic genome editing requires therapeutics that are generalizable to a broad range of patients. Targeted insertion of promoterless transgenes can ensure that edits are permanent and broadly applicable while minimizing risks
Externí odkaz:
https://doaj.org/article/40cb0ffc6dfe4a53a49a6c7a56786698
Autor:
Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel H. Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesy
Externí odkaz:
https://doaj.org/article/ed795593e77944b1aba45644fccaf0d5
Autor:
Nunzia Pastore, Tuong Huynh, Niculin J. Herz, Alessia Calcagni’, Tiemo J. Klisch, Lorenzo Brunetti, Kangho Ho Kim, Marco De Giorgi, Ayrea Hurley, Annamaria Carissimo, Margherita Mutarelli, Niya Aleksieva, Luca D’Orsi, William R. Lagor, David D. Moore, Carmine Settembre, Milton J. Finegold, Stuart J. Forbes, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and t
Externí odkaz:
https://doaj.org/article/dac8c6aa736f4598a4966ab084bf32fc
Autor:
Ayrea Hurley, William R. Lagor
Publikováno v:
Current Atherosclerosis Reports. 24:75-84
Purpose of Review This review examines recent progress in somatic genome editing for cardiovascular disease. We briefly highlight new gene editing approaches, delivery systems, and potential targets in the liver. Recent Findings In recent years, new
Autor:
Mia Furgurson, Ayrea Hurley, Jun Han, Alexandria M. Doerfler, Ang Li, Jason C. Burton, Christoph H. Borchers, Marco De Giorgi, William R. Lagor, Rachel H. Hsu, Kalyani R. Patel, Kelsey E Jarrett
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770616831edb479aac432495d2555db3
Autor:
Ciaran M. Lee, Charles P. Venditti, Jessica L. Schneller, Ang Li, Randy J. Chandler, Sangho Myung, Leah E. Venturoni, Gang Bao, Ayrea Hurley, Thomas J. Cradick, William R. Lagor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 619-632 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Methylmalonic acidemia (MMA) is a metabolic disorder most commonly caused by mutations in the methylmalonyl-CoA mutase (MMUT) gene. Although adeno-associated viral (AAV) gene therapy has been effective at correcting the disease phenotype in MMA mouse
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Dolichol is a nonsterol isoprenoid derived from the mevalonate pathway. Dehydrodolichyl diphosphate synthase subunit (DHDDS) is a branch point enzyme that - in complex with Nogo-B receptor (NgBR) - catalyzes the first committed step of dolichol biosy
Autor:
Karl-Dimiter Bissig, William R. Lagor, Harrison E. Smith, Mercedes Barzi, Marco De Giorgi, Jonathan D. Brown, Gang Bao, Ayrea Hurley, Nikitha Cherayil, Charles Y. Lin, Ang Li, Alexandria M. Doerfler
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 656-669 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 656-669 (2021)
Clinical application of somatic genome editing requires therapeutics that are generalizable to a broad range of patients. Targeted insertion of promoterless transgenes can ensure that edits are permanent and broadly applicable while minimizing risks
Autor:
Abbhirami Rajagopal, Abiodun Oluyomi, Acara E. Turner, Adedoyin Johnson, Alfred Flores, Alfredo Echeverria, Ali Abbas Asghar-Ali, Alyssa Eason, Amy Orange, Andile Dube, Andres Bryan, Andrew Arvizu, Anil T. Mangla, Anjali Deendyal, Anjali Ramoutar, Anna M. Jilla, Annise Wilson, Antonio Jimenez, Ardawna Jael Green, Avani Patel, Aya Itani, Ayrea Hurley, Bess Biscocho, Beverly I. Anaele, Blessing Felix-Okoroj, Brittany Adams, Brooke Wagen, Camden J. Hallmark, Carole E. Johnson, Charles Park, Chaya Prasad, Chris Lavy, Chris Ulack, Christina Maxey, Christopher Nemeh, Dakota Rodgers, Danielle Gonzales, Danielle Whitman, Darius B. Dawson, David Latini, Debra Canales, Debra Dianne Murray, Deepa Dongarwar, Deepu Karri, Derek L. Lockett, Dhitinut Ratnapradipa, Dr. Emma Santa Maria, Edgardo Ordonez, Elisha Acosta, Elyse Lopez, Emmanuella Oduguwa, Erica Chow, Eunique L. Williams, Farzanna S. Haffizulla, Fernando X. Cuascut, Hamisu M. Salihu, Ibeth Caceres, Ionna D. Athanassaki, Jacob Atkins, Jacquelin Rodriguez, Jairo Barrantes Perez, Jalyce Taylor, Jeffery Joy, Jennifer Chang, Jennifer Lopez, Jennifer R. Gaertner-Otto, Jennifer Spinler, Jensine’ Norman, Joel Suarez, Jordan Jones, Joslyn Gober, Jqar Washington, Justin Magrat, Karen Armknecht, Katherine Dowdell, Kathleen McDeavitt, Katie Kirk, Kaylinda Tran, Kaylyn Snook, Kelsey Fitzhugh, Kelsey Jarrett, Kendal D. Hirschi, Kendra Ratnapradipa, Kobby A. Wiafe, Kristen Fisher, Krystal Carter, Laura Rosen, Lauren D. Garner, Lindy Ross, Lyssa Ochoa, Maria I. Castellanos, Maria Vigil, Maricarmen Marroquin, Marina Masciale, Mario Zuniga Palma, Marlene McNeese, Mary Beth Bennett, Matthew Morones, Megan Abadom, Meghna Sebastian, Mia Furgurson, Mia Vento, Michael K. Hole, Michael R. Kauth, Michelle Ludwig, Morgan Castelbuono, Mwamba Mvula, Nadia Sherif, Nancy Trinh, Natalia Rodriguez, Natalie Guerrero, Natasha M. Navejar, Neema Pithia, Nick Christian, Nick Huntington-Klein, Nicole Gras, Nina Truong, Norma Perez, Olusegun Bakare, Paige Hoyer, Patrick Costello, Patrick Hardigan, Paul Nakata, Rachel McCommon, Rachelle Wanser, Ramona Parker, Renee Lastrapes, Ria Brown, Robin P. Goin-Kochel, Russell McIntire, Samantha Janfaza, Samuel E. Willis, Sana Erbati, Sang (Sam) Pak, Sara L. Grisales, Sarah Gustafson, Sean Liu, Sergio M. Navarro, Shelby Johnson, Sherry Pinkstaff, Shetal Amin, Shital M. Patel, Sruthi Thomas, Taelor Farrow, Tara Everett, Terri L. Fletcher, Titilope Fasipe, Toi B. Harris, Torrence Tran, Trung Nguyen, Valencia P. Walker, Vicki Mercado, Victor Cheuy, Victoria Iwinski, Whitney Williams, William Lagor, William Robinson, Yue Xie
Publikováno v:
International Journal of Maternal and Child Health and AIDS
International Journal of Maternal and Child Health and AIDS, Vol 9, Iss 3 (2020)
International Journal of Maternal and Child Health and AIDS, Vol 9, Iss 3 (2020)
Advancing Health Equity Through Innovations and Technology This year’s summit was unique given the COVID-19 pandemic: a major global outbreak that has imposed severe restrictions in all aspects of our life. At the outset, we were faced with three m