ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Autor: Letronne, Florent, Laumet, Geoffroy, Ayral, Anne-Marie, Chapuis, Julien, Demiautte, Florie, Laga, Mathias, Vandenberghe, Michel, Malmanche, Nicolas, Leroux, Florence, Eysert, Fanny, Sottejeau, Yoann, Chami, Linda, Flaig, Amandine, Bauer, Charlotte, Dourlen, Pierre, Lesaffre, Marie, Delay, Charlotte, Huot, Ludovic, Dumont, Julie, Werkmeister, Elisabeth, Lafont, Franck, Mendes, Tiago, Hansmannel, Franck, Dermaut, Bart, Deprez, Benoit, Herard, Anne-Sophie, Dhenain, Marc, Souedet, Nicolas, Pasquier, Florence, Tulasne, David, Berr, Claudine, Hauw, Jean-Jacques, Lemoine, Yves, Amouyel, Philippe, Mann, David, Déprez, Rebecca, Checler, Frédéric, Hot, David, Delzescaux, Thierry, Gevaert, Kris, Lambert, Jean-Charles

Publikováno v: EBioMedicine, Elsevier, 2016, 9, pp.278-292

Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amy-loid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcript

Externí odkaz: http://arxiv.org/abs/1906.07511

Voxel-Based Statistical Analysis of 3D Immunostained Tissue Imaging

Autor: Vandenberghe, Michel, Souedet, Nicolas, Herard, Anne-Sophie, Ayral, Anne-Marie, Letronne, Florent, Balbastre, Yael, Sadouni, Elmahdi, Hantraye, Philippe, Dhenain, Marc, Frouin, Frédérique, Lambert, Jean-Charles, Delzescaux, Thierry

Publikováno v: Frontiers in Neuroscience
Frontiers in Neuroscience, 2018, 12, ⟨10.3389/fnins.2018.00754⟩
Frontiers in Neuroscience, Frontiers, 2018, 12, ⟨10.3389/fnins.2018.00754⟩

International audience; Recently developed techniques to visualize immunostained tissues in 3D and in large samples have expanded the scope of microscopic investigations at the level of the whole brain. Here, we propose to adapt voxel-based statistic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b314139b7e323f3ebfec7b8f6d654f00
https://hal.science/hal-02155742

FERMT2 cleavage impacts APP metabolism in a Src‐dependent manner.

Autor: NAJDEK, Chloé, Demiautte, Florie, Ayral, Anne‐Marie, Flaig, Amandine, Eysert, Fanny, Lambert, Jean‐Charles, Chapuis, Julien

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 13, Vol. 19, p1-1, 1p

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

Autor: Chapuis, Julien, Flaig, Amandine, Grenier-Boley, Benjamin, Eysert, Fanny, Pottiez, Virginie, Deloison, Gaspard, Vandeputte, Alexandre, Ayral, Anne-Marie, Mendes, Tiago, Desai, Shruti, Goate, Alison M., Kauwe, John S. K., Leroux, Florence, Herledan, Adrien, Demiautte, Florie, Bauer, Charlotte, Checler, Fréderic, Petersen, Ronald C., Blennow, Kaj, Zetterberg, Henrik, Minthon, Lennart, Van Deerlin, Vivianna M., Lee, Virginia Man-Yee, Shaw, Leslie M., Trojanowski, John Q., Albert, Marilyn, Moghekar, Abhay, O’Brien, Richard, Peskind, Elaine R., Malmanche, Nicolas, Schellenberg, Gerard D., Dourlen, Pierre, Song, Ok-Ryul, Cruchaga, Carlos, Amouyel, Philippe, Deprez, Benoit, Brodin, Priscille, Lambert, Jean-Charles

Publikováno v: Acta Neuropathologica

Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer’s disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the “post-GWAS” era.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::76b4263e011e205abb353c7b126d868c
https://pubmed.ncbi.nlm.nih.gov/27933404

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.