Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ayona T Silva"'
Publikováno v:
Neuroscience Letters. 517:102-106
Oxidative stress is widely recognized to contribute to neuronal death during various pathological conditions and aging. In the enteric nervous system (ENS), reactive oxygen species have been implicated in the mechanism of age-associated neuronal loss
Publikováno v:
FEMS Microbiology Letters. 110:175-178
Experimentally, Gram-negative septic shock can be prevented by the prophylactic use of an anti-TNF-alpha monoclonal antibody. The clinical similarity between Gram-negative and Gram-positive septic shock suggested that anti-TNF-alpha therapy might hav
Publikováno v:
Brain research. 1218
Identification of the stem cell niche is crucial for understanding the factors that regulate these cells. Rodent enteric neural crest-derived stem cells have previously been isolated by flow cytometry and culture of cell suspensions from the outer sm
Publikováno v:
Journal of Infectious Diseases. 162:421-427
A monoclonal antibody to recombinant murine tumor necrosis factor-alpha (TNF alpha), TN3-19.12, was used to explore pathogenetic mechanisms and therapeutic strategies in gram-negative shock. In mice receiving an LD90 dose of Escherichia coli O111, TN
Publikováno v:
Journal of Infectious Diseases. 162:454-459
To study the role of cytokines as mediators of endotoxin-induced shock, the serum levels of tumor necrosis factor (TNF) and interleukin-6 (IL-6) were compared in mice receiving either a monoclonal antibody to endotoxin core (clone 20), an irrelevant
Publikováno v:
Brain research. Molecular brain research. 107(1)
Glial cell line-derived neurotrophic factor family receptor alpha-2 (GFR alpha-2) is a GPI-linked receptor that preferentially binds neurturin (NTN), a member of the glial cell line-derived neurotrophic factor (GDNF) family. Three splice isoforms of
Publikováno v:
Neuroscience letters. 278(3)
A number of neurotrophic factors have been implicated in the prenatal development of the enteric nervous system. Although several of these factors continue to be expressed in the gut during postnatal life, their actions on postnatal enteric neurons a
Publikováno v:
The Journal of infectious diseases. 169(2)
Nitric oxide (NO) has been proposed as a mediator of hypotension in septic shock. The aim of this study was to determine whether an inhibitor of NO production, NG-monomethyl-L-arginine (L-NMMA), was able to protect against death in two murine models
Publikováno v:
Critical care medicine. 21(8)
OBJECTIVE To examine the effect of a monoclonal antibody to tumor necrosis factor-alpha (TNF-alpha) in a murine model of shock due to Streptococcus pyogenes. DESIGN Prospective, multiexperimental, randomized, controlled trial. SETTING University hosp
Publikováno v:
The Journal of infectious diseases. 168(1)