Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ayodeji A. Agbowuro"'
Autor:
Abiodun Anifowose, Chalet Tan, Binghe Wang, Ayodeji A. Agbowuro, Wen Lu, Xiaoxiao Yang, Ravi Tripathi
Publikováno v:
Med Chem Res
We previously reported a series of p53-elevating anthraquinone compounds with considerable cytotoxicity for acute lymphatic leukemia (ALL) cells. To further develop this class of compounds, we examined the effect of a few key structural features on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113548c4cc2383fe172e33ef363dd76b
https://doi.org/10.1007/s00044-020-02563-y
https://doi.org/10.1007/s00044-020-02563-y
Publikováno v:
Medicinal Chemistry Research. 29:1105-1121
The potentiation of p53 activity through inhibition of its negative regulator MDM2 is an attractive strategy for anticancer therapy. Much progress has been made in the last decade in a diverse range of areas related to p53 and MDM2. This review focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51b161069ee042c450d2fa62b6f9928
https://doi.org/10.1007/s00044-020-02574-9
https://doi.org/10.1007/s00044-020-02574-9
Autor:
Rami Mazraani, Alexandra Springwald, Emma Peel, Allan B. Gamble, Jimin Hwang, Joel D. A. Tyndall, James W. Marsh, Wilhelmina M. Huston, Laura C. McCaughey, Ayodeji A. Agbowuro
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:4185-4199
© 2019 Elsevier Ltd Chlamydia trachomatis high temperature requirement A (CtHtrA) is a serine protease that performs proteolytic and chaperone functions in pathogenic Chlamydiae; and is seen as a prospective drug target. This study details the strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d01ccb674a5d87ca64e0e06ea72dca7
https://doi.org/10.1016/j.bmc.2019.07.049
https://doi.org/10.1016/j.bmc.2019.07.049
Publikováno v:
International Journal of Biochemistry Research & Review. :1-5
Despite the wide ethnomedicinal applications of Ficus exasperata, little is known about the active principles responsible for the observed biological effects, thus limiting opportunities for further therapeutic applications. The bioassay guided chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f5585a2967931dc080d456b60f3d77c
https://doi.org/10.9734/ijbcrr/2019/v25i330075
https://doi.org/10.9734/ijbcrr/2019/v25i330075
Autor:
Laura C. McCaughey, Rami Mazraani, Allan B. Gamble, Wilhelmina M. Huston, Joel D. A. Tyndall, Ayodeji A. Agbowuro
© 2017 Elsevier Ltd JO146, a mixture of two diastereomers of a peptidic phosphonate inhibitor for Chlamydial HtrA (CtHtrA), has reported activity against Chlamydia species in both human and koala. In this study we isolated the individual diastereome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4281c64d7cd6f3af8677a168bd304a
https://ora.ox.ac.uk/objects/uuid:3fd023e4-3d15-4adc-abb7-4da158ef2ed4
https://ora.ox.ac.uk/objects/uuid:3fd023e4-3d15-4adc-abb7-4da158ef2ed4
Publikováno v:
Medicinal Research Reviews. 38:1295-1331
© 2017 Wiley Periodicals, Inc. There are numerous proteases of pathogenic organisms that are currently targeted for therapeutic intervention along with many that are seen as potential drug targets. This review discusses the chemical and biological m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb75c2f9bfc65c67567621ad5c8a9ab
https://doi.org/10.1002/med.21475
https://doi.org/10.1002/med.21475
Publikováno v:
Dissolution Technologies. 19:59-64
With the introduction of artemisinin-combination therapies (ACTs) as the standard recommended treatment for falciparum malaria by the World Health Organization (WHO) and its adoption by most malaria-endemic countries like Nigeria, the only available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57553d629265b34a00c5f08fc6b6e2f4
https://doi.org/10.14227/dt190112p59
https://doi.org/10.14227/dt190112p59