VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model

Autor: Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen, Sarah Louise Christensen

Publikováno v: The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-12 (2024)

Abstract Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine attacks and a recent

Externí odkaz: https://doaj.org/article/1b5638b4204d4c57a3832603fc0281f0

Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease

Autor: Isabelle L. Sumner, Ross A. Edwards, Ayodeji A. Asuni, Jessica L. Teeling

Publikováno v: Frontiers in Neuroscience, Vol 12 (2018)

There are nearly 50 million people with Alzheimer's disease (AD) worldwide and currently no disease modifying treatment is available. AD is characterized by deposits of Amyloid-β (Aβ), neurofibrillary tangles, and neuroinflammation, and several dru

Externí odkaz: https://doaj.org/article/ec3416e15b894065b1b232b413dac31a

Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer’s Disease

Autor: Allan Stensballe, Kenneth Kastaniegaard, Christiane Volbracht, Joakim Bastrup, Ayodeji A. Asuni

Publikováno v: Bastrup, J, Kastaniegaard, K, Asuni, A A, Volbracht, C & Stensballe, A 2020, ' Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 73, no. 1, pp. 393-411 . https://doi.org/10.3233/JAD-190652

Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). The main constituent of amyloid plaques is amyloid-β peptides, but a complex interplay of other infiltrating proteins also co-localizes. We hypothesized that proteomic analysis co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf8ca80eac3e13babdf8755e474e5a8
https://doi.org/10.3233/jad-190652

Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential

Autor: Thomas E. Wuensche, Natascha Stergiou, Iris Mes, Mariska Verlaan, Maxime Schreurs, Esther J. M. Kooijman, Bart Janssen, Albert D. Windhorst, Allan Jensen, Ayodeji A. Asuni, Benny Bang-Andersen, Wissam Beaino, Guus A. M. S. Dongen, Danielle J. Vugts

Publikováno v: Theranostics, 12(16), 7067-7079. Ivyspring International Publisher
Wuensche, T E, Stergiou, N, Mes, I, Verlaan, M, Schreurs, M, Kooijman, E J M, Janssen, B, Windhorst, A D, Jensen, A, Asuni, A A, Bang-Andersen, B, van Dongen, G A M S, Beaino, W & Vugts, D J 2022, ' Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – the choice of chelator is essential ', Theranostics, vol. 12, no. 16, pp. 7067-7079 . https://doi.org/10.7150/thno.73509

The accelerated approval of the monoclonal antibody (mAb) aducanumab as a treatment option for Alzheimer’s Disease and the continued discussions about its efficacy have shown that a better understanding of immunotherapy for the treatment of neurode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4d3375c16493f62b237d91b0a1ba2a
https://research.vumc.nl/en/publications/b7328b80-aecb-4811-90b2-07640111d96c

Chronic stress induces NPD-like behavior in APPPS1 and WT mice with subtle differences in gene expression

Autor: Amalie Clement, Allan Stensballe, Mads M. Pedersen, Ayodeji A. Asuni, Ove Wiborg

Publikováno v: Clement, A, Pedersen, M M, Stensballe, A, Wiborg, O & Asuni, A A 2021, ' Chronic stress induces NPD-like behavior in APPPS1 and WT mice with subtle differences in gene expression ', Genes, Brain and Behavior, vol. 20, no. 8, e12766 . https://doi.org/10.1111/gbb.12766

Neuropsychiatric disturbances (NPDs) are considered hallmarks of Alzheimer's disease (AD). Nevertheless, treatment of these symptoms has proven difficult and development of safe and effective treatment options is hampered by the limited understanding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e2d87c3bb82af8e5a9d1bbaef6e8d6
https://pubmed.ncbi.nlm.nih.gov/34382343