Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Aynur O. Aptula"'
Autor:
Kyle P. Glover, Yumi Akahori, Michelle O. Kenyon, David Jones, Angela White, Patricia Ruiz, Dave Bower, Mark Powley, Janet Moser, Naomi L. Kruhlak, Diana Suarez-Rodriguez, Laura Custer, Chia Wen Hsu, Masamitsu Honma, Joel P. Bercu, Steve Gutsell, Krista L. Dobo, Bernhard Majer, Andrew Teasdale, Lidiya Stavitskaya, Aynur O. Aptula, Barry Hardy, Candice Y. Johnson, Scott S. Auerbach, Nichola Gellatly, Rositsa Serafimova, David Allen, Samantha E. Gad-McDonald, Alessandro Brigo, Lennart T. Anger, Kevin P. Cross, Pete Watts, Louise Neilson, Wendy Simpson, Jedd Hillegass, Véronique Gervais, Penny Leavitt, Jui-Hua Hsieh, Kristine L. Witt, Reinhard Stidl, Magdalena Dettwiler, K. Hughes, Romualdo Benigni, Lisa Beilke, Marlene T. Kim, Scott A. Masten, Adam Woolley, Phillip Bellion, Kevin A. Ford, David T. Szabo, Alexander Amberg, Anna Vuorinen, Brian A. Wall, Mark T. D. Cronin, Marie C. Fortin, Zoryana Cammerer, Benoît Schilter, Glenn J. Myatt, Klaus Kümmerer, Ernst Ahlberg, Grace Patlewicz, M. Vijayaraj Reddy, Craig Zwickl, Donald P. Quigley, David Woolley, Tudor I. Oprea, Jacky Van Gompel, Ewan D. Booth, Alexandre Paulino, Wolfgang Muster, Sunil Kulkarni, Alejandra Trejo-Martin, Moiz Mumtaz, Andrea Richarz, Joerg Wichard, James Harvey, Susanne Glowienke, Elena Lo Piparo, Natalie Burden, Catrin Hasselgren, Jean Pierre Valentin, Robert A. Jolly, Scott Miller, Ray Kemper
Publikováno v:
Myatt, G J, Ahlberg, E, Akahori, Y, Allen, D, Amberg, A, Anger, L T, Aptula, A, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Burden, N, Cammerer, Z, Cronin, M T D, Cross, K P, Custer, L, Dettwiler, M, Dobo, K, Ford, K A, Fortin, M C, Gad-McDonald, S E, Gellatly, N, Gervais, V, Glover, K P, Glowienke, S, Van Gompel, J, Gutsell, S, Hardy, B, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Hughes, K, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kim, M T, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Majer, B, Masten, S, Miller, S, Moser, J, Mumtaz, M, Muster, W, Neilson, L, Oprea, T I, Patlewicz, G, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Ruiz, P, Schilter, B, Serafimova, R, Simpson, W, Stavitskaya, L, Stidl, R, Suarez-Rodriguez, D, Szabo, D T, Teasdale, A, Trejo-Martin, A, Valentin, J P, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Hasselgren, C 2018, ' In silico toxicology protocols ' Regulatory toxicology and pharmacology : RTP, vol 96, pp. 1-17 . DOI: 10.1016/j.yrtph.2018.04.014
Myatt, G J, Ahlberg, E, Akahori, Y, Allen, D, Amberg, A, Anger, L T, Aptula, A, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Burden, N, Cammerer, Z, Cronin, M T D, Cross, K P, Custer, L, Dettwiler, M, Dobo, K, Ford, K A, Fortin, M C, Gad-McDonald, S E, Gellatly, N, Gervais, V, Glover, K P, Glowienke, S, Van Gompel, J, Gutsell, S, Hardy, B, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Hughes, K, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kim, M T, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Majer, B, Masten, S, Miller, S, Moser, J, Mumtaz, M, Muster, W, Neilson, L, Oprea, T I, Patlewicz, G, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Ruiz, P, Schilter, B, Serafimova, R, Simpson, W, Stavitskaya, L, Stidl, R, Suarez-Rodriguez, D, Szabo, D T, Teasdale, A, Trejo-Martin, A, Valentin, J P, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Hasselgren, C 2018, ' In silico toxicology protocols ', Regulatory toxicology and pharmacology : RTP, vol. 96, pp. 1-17 . https://doi.org/10.1016/j.yrtph.2018.04.014
Myatt, G J, Ahlberg, E, Akahori, Y, Allen, D, Amberg, A, Anger, L T, Aptula, A, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Burden, N, Cammerer, Z, Cronin, M T D, Cross, K P, Custer, L, Dettwiler, M, Dobo, K, Ford, K A, Fortin, M C, Gad-McDonald, S E, Gellatly, N, Gervais, V, Glover, K P, Glowienke, S, Van Gompel, J, Gutsell, S, Hardy, B, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Hughes, K, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kim, M T, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Majer, B, Masten, S, Miller, S, Moser, J, Mumtaz, M, Muster, W, Neilson, L, Oprea, T I, Patlewicz, G, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Ruiz, P, Schilter, B, Serafimova, R, Simpson, W, Stavitskaya, L, Stidl, R, Suarez-Rodriguez, D, Szabo, D T, Teasdale, A, Trejo-Martin, A, Valentin, J P, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Hasselgren, C 2018, ' In silico toxicology protocols ', Regulatory toxicology and pharmacology : RTP, vol. 96, pp. 1-17 . https://doi.org/10.1016/j.yrtph.2018.04.014
The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related pred
Autor:
Aynur O. Aptula, David W. Roberts
Publikováno v:
Contact Dermatitis. 72:347-351
Publikováno v:
Chemical research in toxicology. 30(2)
Epoxides are known or proposed to be involved in skin sensitization in various ways. Some are encountered directly, and others have been shown to be formed abiotically and metabolically from various unsaturated chemicals. They can react as SN2 electr
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 80
The Local Lymph Node Assay (LLNA) is the most common in vivo regulatory toxicology test for skin sensitisation, quantifying potency as the EC3, the concentration of chemical giving a threefold increase in thymidine uptake in the local lymph node. Exi
Autor:
Joanna Rowland, Silvia Teissier, Thomas Teichert, Carsten Goebel, Jalila Hibatallah, Petra Winkler, Nicola Gilmour, Petra S. Kern, Nicolas Tessier, Hans Ulrich Weltzien, Julia Scheel, Monique Marrec-Fairley, Nadège Ade, Detlef Keller, Daisuke Araki, Chris Seaman, Nathalie Alépée, Andreas Schepky, Pierre Aeby, Annette Kirst, Florian Schellauf, Eric K. Dufour, Bob Safford, Gavin Maxwell, Aynur O. Aptula
Publikováno v:
Regulatory Toxicology and Pharmacology. 63(1):40-52
Characterisation of skin sensitisation potential is a key endpoint for the safety assessment of cosmetic ingredients especially when significant dermal exposure to an ingredient is expected. At present the mouse local lymph node assay (LLNA) remains
Autor:
Anna Bal-Price, J.G.M. Bessems, Hannu Komulainen, Susan P. Felter, Klaus Ejner Andersen, Emanuela Testai, Greet Schoeters, Aldert H. Piersma, George P. Daston, Valérie Zuang, Vera Rogiers, Gavin Maxwell, Ursula Gundert-Remy, David A. Basketter, Ulrike Bernauer, Mathieu Vinken, Ian Kimber, Aynur O. Aptula, Mark T. D. Cronin, Emilio Benfenati, Stuart Creton, George Loizou, Elise Grignard, Esther Brandon, Alexandre Angers-Loustau, Albrecht Poth, Joost H.M. van Delft, Michael Schwarz, Sofia B. Leite, Sarah Adler, Jan van Benthem, Pascal Phrakonkham, Jos C. S. Kleinjans, Sandra Coecke, Sharon Munn, Joachim Kreysa, Wolfgang Dekant, Silvia Casati, Guillermo Repetto, Henk Van Loveren, Reinhard Kreiling, Thomas H. Broschard, Susanne Bremer, Olavi Pelkonen, Stefan Pfuhler, Alan R. Boobis, Paolo Mazzatorta, Pilar Prieto, Andrew Worth, Jose-Manuel Zaldivar, Hanna Tähti, Raffaella Corvi, Tuula Heinonen, Frédéric Y. Bois, Rositsa Serafimova
Publikováno v:
Vrije Universiteit Brussel
Archives of Toxicology, 85(5), 367-485. Springer
Archives of toxicology
Adler, S, Basketter, D, Creton, S, Pelkonen, O, van Benthem, J, Zuang, V, Andersen, K E, Angers-Loustau, A, Aptula, A, Bal-Price, A, Benfenati, E, Bernauer, U, Bessems, J, Bois, F Y, Boobis, A, Brandon, E, Bremer, S, Broschard, T, Casati, S, Coecke, S, Corvi, R, Cronin, M, Daston, G, Dekant, W, Felter, S, Grignard, E, Gundert-Remy, U, Heinonen, T, Kimber, I, Kleinjans, J, Komulainen, H, Kreiling, R, Kreysa, J, Leite, S B, Loizou, G, Maxwell, G, Mazzatorta, P, Munn, S, Pfuhler, S, Phrakonkham, P, Piersma, A, Poth, A, Prieto, P, Repetto, G, Rogiers, V, Schoeters, G, Schwarz, M, Serafimova, R, Tähti, H, Testai, E, van Delft, J, van Loveren, H, Vinken, M, Worth, A & Zaldivar, J-M 2011, ' Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010 ', Archives of Toxicology, vol. 85, no. 5, pp. 367-485 . https://doi.org/10.1007/s00204-011-0693-2
Archives of Toxicology, 85(5), 367-485. Springer
Archives of toxicology
Adler, S, Basketter, D, Creton, S, Pelkonen, O, van Benthem, J, Zuang, V, Andersen, K E, Angers-Loustau, A, Aptula, A, Bal-Price, A, Benfenati, E, Bernauer, U, Bessems, J, Bois, F Y, Boobis, A, Brandon, E, Bremer, S, Broschard, T, Casati, S, Coecke, S, Corvi, R, Cronin, M, Daston, G, Dekant, W, Felter, S, Grignard, E, Gundert-Remy, U, Heinonen, T, Kimber, I, Kleinjans, J, Komulainen, H, Kreiling, R, Kreysa, J, Leite, S B, Loizou, G, Maxwell, G, Mazzatorta, P, Munn, S, Pfuhler, S, Phrakonkham, P, Piersma, A, Poth, A, Prieto, P, Repetto, G, Rogiers, V, Schoeters, G, Schwarz, M, Serafimova, R, Tähti, H, Testai, E, van Delft, J, van Loveren, H, Vinken, M, Worth, A & Zaldivar, J-M 2011, ' Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010 ', Archives of Toxicology, vol. 85, no. 5, pp. 367-485 . https://doi.org/10.1007/s00204-011-0693-2
The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics on the market in Europe after 2013. In that context, the European Commission invited stakeholder bodies (industry, non-governmental organisations, EU Member Stat
Autor:
Cindy A. Ryan, Petra S. Kern, Ian Kimber, Aynur O. Aptula, David A. Basketter, G. Frank Gerberick
Publikováno v:
Dermatitis. 21:8-32
BACKGROUND: Development, evaluation and validation of alternatives to skin sensitisation testing require the availability of reliable databases with which comparative analyses can be conducted to establish performance characteristics. To facilitate t
Publikováno v:
Chemical Research in Toxicology. 23:228-234
A diverse set of 60 haloaliphatic compounds were evaluated for reactivity with cysteine thiol groups in the previously described RC(50) assay using glutathione (GSH) as a model nucleophile. Reactivity was quantified by the RC(50) value, the concentra
Publikováno v:
Chemical Research in Toxicology. 22:1541-1547
It is well-known that aromatic diamino-, dihydroxy-, and amino-hydroxy compounds, with NH(2) and OH groups in ortho- or para-positions relative to each other, are strong skin sensitizers. In this paper, we analyze published potency and cross-reactivi
Publikováno v:
QSAR & Combinatorial Science. 27:60-76
This minireview describes the state-of-the-art of available (Q)SARs/expert systems for skin sensitization and evaluates their utility for potential regulatory use. It is one of a series of minireviews in this journal and is based on an in-depth revie