Výsledky vyhledávání - "Aynur O. Aptula"

In silico toxicology protocols

Autor: Kyle P. Glover, Yumi Akahori, Michelle O. Kenyon, David Jones, Angela White, Patricia Ruiz, Dave Bower, Mark Powley, Janet Moser, Naomi L. Kruhlak, Diana Suarez-Rodriguez, Laura Custer, Chia Wen Hsu, Masamitsu Honma, Joel P. Bercu, Steve Gutsell, Krista L. Dobo, Bernhard Majer, Andrew Teasdale, Lidiya Stavitskaya, Aynur O. Aptula, Barry Hardy, Candice Y. Johnson, Scott S. Auerbach, Nichola Gellatly, Rositsa Serafimova, David Allen, Samantha E. Gad-McDonald, Alessandro Brigo, Lennart T. Anger, Kevin P. Cross, Pete Watts, Louise Neilson, Wendy Simpson, Jedd Hillegass, Véronique Gervais, Penny Leavitt, Jui-Hua Hsieh, Kristine L. Witt, Reinhard Stidl, Magdalena Dettwiler, K. Hughes, Romualdo Benigni, Lisa Beilke, Marlene T. Kim, Scott A. Masten, Adam Woolley, Phillip Bellion, Kevin A. Ford, David T. Szabo, Alexander Amberg, Anna Vuorinen, Brian A. Wall, Mark T. D. Cronin, Marie C. Fortin, Zoryana Cammerer, Benoît Schilter, Glenn J. Myatt, Klaus Kümmerer, Ernst Ahlberg, Grace Patlewicz, M. Vijayaraj Reddy, Craig Zwickl, Donald P. Quigley, David Woolley, Tudor I. Oprea, Jacky Van Gompel, Ewan D. Booth, Alexandre Paulino, Wolfgang Muster, Sunil Kulkarni, Alejandra Trejo-Martin, Moiz Mumtaz, Andrea Richarz, Joerg Wichard, James Harvey, Susanne Glowienke, Elena Lo Piparo, Natalie Burden, Catrin Hasselgren, Jean Pierre Valentin, Robert A. Jolly, Scott Miller, Ray Kemper

Publikováno v: Myatt, G J, Ahlberg, E, Akahori, Y, Allen, D, Amberg, A, Anger, L T, Aptula, A, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Burden, N, Cammerer, Z, Cronin, M T D, Cross, K P, Custer, L, Dettwiler, M, Dobo, K, Ford, K A, Fortin, M C, Gad-McDonald, S E, Gellatly, N, Gervais, V, Glover, K P, Glowienke, S, Van Gompel, J, Gutsell, S, Hardy, B, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Hughes, K, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kim, M T, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Majer, B, Masten, S, Miller, S, Moser, J, Mumtaz, M, Muster, W, Neilson, L, Oprea, T I, Patlewicz, G, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Ruiz, P, Schilter, B, Serafimova, R, Simpson, W, Stavitskaya, L, Stidl, R, Suarez-Rodriguez, D, Szabo, D T, Teasdale, A, Trejo-Martin, A, Valentin, J P, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Hasselgren, C 2018, ' In silico toxicology protocols ' Regulatory toxicology and pharmacology : RTP, vol 96, pp. 1-17 . DOI: 10.1016/j.yrtph.2018.04.014
Myatt, G J, Ahlberg, E, Akahori, Y, Allen, D, Amberg, A, Anger, L T, Aptula, A, Auerbach, S, Beilke, L, Bellion, P, Benigni, R, Bercu, J, Booth, E D, Bower, D, Brigo, A, Burden, N, Cammerer, Z, Cronin, M T D, Cross, K P, Custer, L, Dettwiler, M, Dobo, K, Ford, K A, Fortin, M C, Gad-McDonald, S E, Gellatly, N, Gervais, V, Glover, K P, Glowienke, S, Van Gompel, J, Gutsell, S, Hardy, B, Harvey, J S, Hillegass, J, Honma, M, Hsieh, J H, Hsu, C W, Hughes, K, Johnson, C, Jolly, R, Jones, D, Kemper, R, Kenyon, M O, Kim, M T, Kruhlak, N L, Kulkarni, S A, Kümmerer, K, Leavitt, P, Majer, B, Masten, S, Miller, S, Moser, J, Mumtaz, M, Muster, W, Neilson, L, Oprea, T I, Patlewicz, G, Paulino, A, Lo Piparo, E, Powley, M, Quigley, D P, Reddy, M V, Richarz, A N, Ruiz, P, Schilter, B, Serafimova, R, Simpson, W, Stavitskaya, L, Stidl, R, Suarez-Rodriguez, D, Szabo, D T, Teasdale, A, Trejo-Martin, A, Valentin, J P, Vuorinen, A, Wall, B A, Watts, P, White, A T, Wichard, J, Witt, K L, Woolley, A, Woolley, D, Zwickl, C & Hasselgren, C 2018, ' In silico toxicology protocols ', Regulatory toxicology and pharmacology : RTP, vol. 96, pp. 1-17 . https://doi.org/10.1016/j.yrtph.2018.04.014

The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related pred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30474fda768266769a029d23592f910
https://doi.org/10.1016/j.yrtph.2018.04.014

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Structure-Potency Relationships for Epoxides in Allergic Contact Dermatitis

Autor: David W. Roberts, Aynur O. Aptula, A.M. Api

Publikováno v: Chemical research in toxicology. 30(2)

Epoxides are known or proposed to be involved in skin sensitization in various ways. Some are encountered directly, and others have been shown to be formed abiotically and metabolically from various unsaturated chemicals. They can react as SN2 electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39832832ac82bf4d0b3095bb0f73d1e9
https://pubmed.ncbi.nlm.nih.gov/28121139

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Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitisation potency. Part 2. The biological variability of the murine Local Lymph Node Assay (LLNA) for skin sensitisation

Autor: Aynur O. Aptula, David W. Roberts, A.M. Api

Publikováno v: Regulatory toxicology and pharmacology : RTP. 80

The Local Lymph Node Assay (LLNA) is the most common in vivo regulatory toxicology test for skin sensitisation, quantifying potency as the EC3, the concentration of chemical giving a threefold increase in thymidine uptake in the local lymph node. Exi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8302ff2727fc2fa0847abf95a09f63c6
https://pubmed.ncbi.nlm.nih.gov/27470439

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Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation

Publikováno v: Regulatory Toxicology and Pharmacology. 63(1):40-52

Characterisation of skin sensitisation potential is a key endpoint for the safety assessment of cosmetic ingredients especially when significant dermal exposure to an ingredient is expected. At present the mouse local lymph node assay (LLNA) remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29020446d6d774073c23b764fe05635c

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Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010

Autor: Anna Bal-Price, J.G.M. Bessems, Hannu Komulainen, Susan P. Felter, Klaus Ejner Andersen, Emanuela Testai, Greet Schoeters, Aldert H. Piersma, George P. Daston, Valérie Zuang, Vera Rogiers, Gavin Maxwell, Ursula Gundert-Remy, David A. Basketter, Ulrike Bernauer, Mathieu Vinken, Ian Kimber, Aynur O. Aptula, Mark T. D. Cronin, Emilio Benfenati, Stuart Creton, George Loizou, Elise Grignard, Esther Brandon, Alexandre Angers-Loustau, Albrecht Poth, Joost H.M. van Delft, Michael Schwarz, Sofia B. Leite, Sarah Adler, Jan van Benthem, Pascal Phrakonkham, Jos C. S. Kleinjans, Sandra Coecke, Sharon Munn, Joachim Kreysa, Wolfgang Dekant, Silvia Casati, Guillermo Repetto, Henk Van Loveren, Reinhard Kreiling, Thomas H. Broschard, Susanne Bremer, Olavi Pelkonen, Stefan Pfuhler, Alan R. Boobis, Paolo Mazzatorta, Pilar Prieto, Andrew Worth, Jose-Manuel Zaldivar, Hanna Tähti, Raffaella Corvi, Tuula Heinonen, Frédéric Y. Bois, Rositsa Serafimova

Publikováno v: Vrije Universiteit Brussel
Archives of Toxicology, 85(5), 367-485. Springer
Archives of toxicology
Adler, S, Basketter, D, Creton, S, Pelkonen, O, van Benthem, J, Zuang, V, Andersen, K E, Angers-Loustau, A, Aptula, A, Bal-Price, A, Benfenati, E, Bernauer, U, Bessems, J, Bois, F Y, Boobis, A, Brandon, E, Bremer, S, Broschard, T, Casati, S, Coecke, S, Corvi, R, Cronin, M, Daston, G, Dekant, W, Felter, S, Grignard, E, Gundert-Remy, U, Heinonen, T, Kimber, I, Kleinjans, J, Komulainen, H, Kreiling, R, Kreysa, J, Leite, S B, Loizou, G, Maxwell, G, Mazzatorta, P, Munn, S, Pfuhler, S, Phrakonkham, P, Piersma, A, Poth, A, Prieto, P, Repetto, G, Rogiers, V, Schoeters, G, Schwarz, M, Serafimova, R, Tähti, H, Testai, E, van Delft, J, van Loveren, H, Vinken, M, Worth, A & Zaldivar, J-M 2011, ' Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010 ', Archives of Toxicology, vol. 85, no. 5, pp. 367-485 . https://doi.org/10.1007/s00204-011-0693-2

The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics on the market in Europe after 2013. In that context, the European Commission invited stakeholder bodies (industry, non-governmental organisations, EU Member Stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e974111045922b66d7c9117f0f0d7f
https://doi.org/10.1007/s00204-011-0693-2

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Local Lymph Node Data for the Evaluation of Skin Sensitization Alternatives: A Second Compilation

Autor: Cindy A. Ryan, Petra S. Kern, Ian Kimber, Aynur O. Aptula, David A. Basketter, G. Frank Gerberick

Publikováno v: Dermatitis. 21:8-32

BACKGROUND: Development, evaluation and validation of alternatives to skin sensitisation testing require the availability of reliable databases with which comparative analyses can be conducted to establish performance characteristics. To facilitate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::168b192ae165ae3dd01e190b7d68eeb2
https://doi.org/10.2310/6620.2009.09038

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Experimental Reactivity Parameters for Toxicity Modeling: Application to the Acute Aquatic Toxicity of SN2 Electrophiles to Tetrahymena pyriformis

Autor: Erika M Wolf, T. Wayne Schultz, David W. Roberts, Aynur O. Aptula

Publikováno v: Chemical Research in Toxicology. 23:228-234

A diverse set of 60 haloaliphatic compounds were evaluated for reactivity with cysteine thiol groups in the previously described RC(50) assay using glutathione (GSH) as a model nucleophile. Reactivity was quantified by the RC(50) value, the concentra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563d2db27ec265be59108addde5a9554
https://doi.org/10.1021/tx9003648

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Chemical Mechanisms for Skin Sensitization by Aromatic Compounds with Hydroxy and Amino Groups

Autor: Aynur O. Aptula, David W. Roberts, Steven J. Enoch

Publikováno v: Chemical Research in Toxicology. 22:1541-1547

It is well-known that aromatic diamino-, dihydroxy-, and amino-hydroxy compounds, with NH(2) and OH groups in ortho- or para-positions relative to each other, are strong skin sensitizers. In this paper, we analyze published potency and cross-reactivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f24b03c6e3f5c6b93920e74eafe644
https://doi.org/10.1021/tx9000336

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A Minireview of Available Skin Sensitization (Q)SARs/Expert Systems

Autor: David W. Roberts, Eugenio Uriarte, Grace Patlewicz, Aynur O. Aptula

Publikováno v: QSAR & Combinatorial Science. 27:60-76

This minireview describes the state-of-the-art of available (Q)SARs/expert systems for skin sensitization and evaluates their utility for potential regulatory use. It is one of a series of minireviews in this journal and is based on an in-depth revie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6f1da44562a70dc5258535406764224
https://doi.org/10.1002/qsar.200710067

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