GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

Autor: Shuxin Hu, Aynun N. Begum, Mychica R. Jones, Mike S. Oh, Walter K. Beech, Beverly Hudspeth Beech, Fusheng Yang, Pingping Chen, Oliver J. Ubeda, Peter C. Kim, Peter Davies, Qiulan Ma, Greg M. Cole, Sally A. Frautschy

Publikováno v: Neurobiology of Disease, Vol 33, Iss 2, Pp 193-206 (2009)

The dysregulation of glycogen synthase kinase-3 (GSK3) has been implicated in Alzheimer disease (AD) pathogenesis and in Aβ-induced neurotoxicity, leading us to investigate it as a therapeutic target in an intracerebroventricular Aβ infusion model.

Externí odkaz: https://doaj.org/article/65c7beeee1864d5d80b5642685e602c8

Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells

Autor: Jose S. Aguilar, Aynun N. Begum, Lourdes Elias, Yiling Hong

Publikováno v: NeuroToxicology. 57:45-53

Silver nanoparticles (AgNPs) are used extensively as anti-microbial agents in various products, but little is known about their potential neurotoxic effects. In this study, we used glutamatergic neurons derived from human embryonic stem cells as a ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcce614f2ddd7d8e432f239dc13f4d1
https://doi.org/10.1016/j.neuro.2016.08.015

Deriving Neural Cells from Pluripotent Stem Cells for Nanotoxicity Testing

Autor: Aynun N. Begum, Nymph Chan, Yiling Hong

Publikováno v: Methods in Molecular Biology ISBN: 9781493989157

Stem cells are undifferentiated biological cells that can differentiate into all lineages under defined control condition. Stem cell neuronal differentiation can faithfully recapitulate stages of neural development and generate neuronal progenitors,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6fb17fbe7589e7aa857255e65284d9a
https://doi.org/10.1007/978-1-4939-8916-4_4

Rapid generation of sub-type, region-specific neurons and neural networks from human pluripotent stem cell-derived neurospheres

Autor: Yiling Hong, Caleigh D. Guoynes, Jane Cho, Jijun Hao, Kabirullah Lutfy, Aynun N. Begum

Publikováno v: Stem Cell Research, Vol 15, Iss 3, Pp 731-741 (2015)
Stem cell research, vol 15, iss 3
Begum, AN; Guoynes, C; Cho, J; Hao, J; Lutfy, K; & Hong, Y. (2015). Rapid generation of sub-type, region-specific neurons and neural networks from human pluripotent stem cell-derived neurospheres. STEM CELL RESEARCH, 15(3), 731-741. doi: 10.1016/j.scr.2015.10.014. UC Office of the President: Tobacco-Related Disease Research Program. Retrieved from: http://www.escholarship.org/uc/item/0n36r5r7

Stem cell-based neuronal differentiation has provided a unique opportunity for disease modeling and regenerative medicine. Neurospheres are the most commonly used neuroprogenitors for neuronal differentiation, but they often clump in culture, which h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d4aa00440618723e53d1064cb16482
http://www.sciencedirect.com/science/article/pii/S187350611500149X

Directed cardiomyogenesis of human pluripotent stem cells by modulating Wnt/β-catenin and BMP signalling with small molecules

Autor: Yiling Hong, Jonathan Alvarez, Jijun Hao, Aynun N. Begum, Xiao-bing Zhang, Jose S. Aguilar

Publikováno v: The Biochemical journal. 469(2)

Cardiomyocytes derived from human pluripotent stem cells (PSCs) are a potential cell source for regenerative medicine, disease modelling and drug development. However, current approaches for in vitro cardiac differentiation of human PSCs are often ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2961822ff3d3fa0a50c63b3a23a8b1e3
https://pubmed.ncbi.nlm.nih.gov/26171831