Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Ayman O.S. El-Kadi"'
Publikováno v:
Current Research in Toxicology, Vol 5, Iss , Pp 100126- (2023)
The detoxification of quinones through NAD(P)H:quinone oxidoreductase (NQO1) is a crucial mechanism to maintain cellular homeostasis. The exposure to heavy metals, specifically methylmercury (MeHg), induces several antioxidant enzymes, including NQO1
Externí odkaz:
https://doaj.org/article/1371aa72018e491db0e80df280e7c9e1
Autor:
Samaa Alrushaid, Neal M. Davies, Judy E. Anderson, Tyson Le, Jaime A. Yáñez, Zaid H. Maayah, Ayman O.S. El-Kadi, Ousama Rachid, Casey L. Sayre, Raimar Löbenberg, Frank J. Burczynski
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 21, Iss 1s (2018)
PURPOSE: MyoNovin is a novel skeletal muscle-regenerating compound developed through synthesis of two nitro groups onto a guaifenesin backbone to deliver nitric oxide to skeletal muscle with a potential to treat muscle atrophy. The purpose of this st
Externí odkaz:
https://doaj.org/article/e895d65cc6e748e6b35ead553dc5471e
Publikováno v:
Pharmaceutics, Vol 9, Iss 1, p 9 (2017)
Cytochrome P450-mediated metabolism of arachidonic acid (AA) is an important pathway for the formation of eicosanoids. The ω-hydroxylation of AA generates significant levels of 20-hydroxyeicosatetraenoic acid (20-HETE) in various tissues. In the cur
Externí odkaz:
https://doaj.org/article/07cac15aa52445f1a2769189323cdb39
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 15, Iss 3 (2012)
Inflammation, the host’s response to infection and injury, is associated with altered expression of genes such as metabolizing enzymes, transporters, receptors and plasma proteins. The purpose of the present work was to characterize the effect of i
Externí odkaz:
https://doaj.org/article/ada35c2c969f4749afb7e20f94c52f50
Autor:
Aws Alshamsan, Samar Hamdy, Saswati Das Saswati Das, Afsaneh Lavasanifar, John Samuel, Ayman O.S. El-Kadi
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 13, Iss 1 (2010)
PURPOSE: Tumors can escape immune eradication by harnessing dendritic cell (DC) maturation. However, DC types used as in vitro models to study tumor-mediated immunosuppression possess fundamental variability that could influence research outcomes. Th
Externí odkaz:
https://doaj.org/article/c9eff949ed4c4a39b441cd9515a55002
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 11, Iss 1 (2008)
PURPOSE. To evaluate the metabolism of amiodarone (AM) to desethylamiodarone (DEA) by selected human and rat cytochrome P450, and the inhibitory effect of ketoconazole (KTZ). METHODS. Some important CYP isoenzymes (rat CYP1A1, 1A2, 2C6, 2C11, 2D1, 2D
Externí odkaz:
https://doaj.org/article/c8bcfd9b28554bfaa805de3f55fccd3e
Publikováno v:
Prostaglandins & Other Lipid Mediators. 168:106749
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66716896d886689f3f736bc5c384a9f4
https://doi.org/10.1016/j.prostaglandins.2023.106749
https://doi.org/10.1016/j.prostaglandins.2023.106749
Publikováno v:
Molecular and Cellular Biochemistry. 477:877-884
Matrix metalloproteinase (MMP) and soluble epoxide hydrolase (sEH) have completely unrelated biological functions, however, their dysregulation produce similar effects on biological systems. Based on the similarity in the reported structural requirem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f19918bc7a5c149ce053824f1b7739
https://doi.org/10.1007/s11010-021-04337-5
https://doi.org/10.1007/s11010-021-04337-5
Autor:
Fadumo Ahmed Isse, Ahmad H. Alammari, Ahmed A. El-Sherbeni, Dion R. Brocks, Ayman O.S. El-Kadi
Publikováno v:
Prostaglandinsother lipid mediators. 165
Arachidonic acid (AA) is a polyunsaturated fatty acid with a structure of 20:4(ω-6). Cytochrome P450s (CYPs) metabolize AA to several regioisomers and enantiomers of hydroxyeicosatetraenoic acids (HETEs). The hydroxy-metabolites (HETEs) exist as ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eafbb9d54d085c4105996cf26ece2a1
https://pubmed.ncbi.nlm.nih.gov/36528330
https://pubmed.ncbi.nlm.nih.gov/36528330
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 46:613-624
Cytochrome P450 (CYP) 1A1 and CYP1B1 enzymes play a significant role in the pathogenesis of cancer and cardiovascular diseases (CVD) such as cardiac hypertrophy and heart failure. Previously, we have demonstrated that R- and S-enantiomers of 19-hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b8c54dd136ff15d5ee70444121b91a1
https://doi.org/10.1007/s13318-021-00699-9
https://doi.org/10.1007/s13318-021-00699-9