Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ayman Al Haj Zen"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Metastasis is the cause of most triple-negative breast cancer deaths, yet anti-metastatic therapeutics remain limited. To develop new therapeutics to prevent metastasis, pathophysiologically relevant assays that recapitulate tumor microenvironment is
Externí odkaz:
https://doaj.org/article/534cc96f5fa046c0b8841d8bb61f1b54
Autor:
Dalal Al‐Sharshani, Dinesh Velayutham, Muthanna Samara, Reham Gazal, Ayman Al Haj Zen, Mohamed A. Ismail, Mahmoud Ahmed, Gheyath Nasrallah, Salma Younes, Nasser Rizk, Sara Hammuda, M. Walid Qoronfleh, Thomas Farrell, Hatem Zayed, Palli Valapila Abdulrouf, Manar AlDweik, John Paul Ben Silang, Alaa Rahhal, Rana Al‐Jurf, Ahmed Mahfouz, Amar Salam, Hilal Al Rifai, Nader I. Al‐Dewik
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 11, Iss 8, Pp n/a-n/a (2023)
Abstract Background Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non‐alcoholic fatty liver disease (NAFLD). Objective The study aimed to investigate the association be
Externí odkaz:
https://doaj.org/article/6ccecb89661f4863820c4206c89e0b14
Autor:
Yosra Bejaoui, Sara Alresheq, Sophie Durand, Marie Vilaire-Meunier, Louise Maillebouis, Ayman Al Haj Zen, André Mégarbané, Nady El Hajj
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundDown Syndrome (DS) is the most common chromosome anomaly in humans and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique, since DS patients have a low risk of developing solid tumors such as breast cancer
Externí odkaz:
https://doaj.org/article/50d1f8dddaac4b9fbd822ef72c563368
Autor:
Andrea Martello, David Mellis, Marco Meloni, Alison Howarth, Daniel Ebner, Andrea Caporali, Ayman Al Haj Zen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 29-43 (2018)
Endothelial cell (EC) proliferation is a crucial event in physiological and pathological angiogenesis. MicroRNAs (miRNAs) have emerged as important modulators of the angiogenic switch. Here we conducted high-content screening of a human miRNA mimic l
Externí odkaz:
https://doaj.org/article/dc8cb931a63c4b539b7ae99df0efb97c
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4891
Angiogenesis is a critical cellular process toward establishing a functional circulatory system capable of delivering oxygen and nutrients to the tissue in demand. In vitro angiogenesis assays represent an important tool for elucidating the biology o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672c537502dd60656000b214c75ded66
https://pubmed.ncbi.nlm.nih.gov/35563280
https://pubmed.ncbi.nlm.nih.gov/35563280
Autor:
Heba Z. Sailem, Ayman Al Haj Zen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Angiogenesis plays a key role in several diseases including cancer, ischemic vascular disease, and Alzheimer’s disease. Chemical genetic screening of endothelial tube formation provides a robust approach for identifying signalling components that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93f0543b9d71473f3c96f6cd4e1ae97
http://link.springer.com/article/10.1038/s41598-020-70440-0
http://link.springer.com/article/10.1038/s41598-020-70440-0
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10585, p 10585 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Arteriogenesis is one of the primary physiological means by which the circulatory collateral system restores blood flow after significant arterial occlusion in peripheral arterial disease patients. Vascular smooth muscle cells (VSMCs) are the predomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e833d5bd188938d871e085b33c8426ab
https://www.mdpi.com/1422-0067/22/19/10585
https://www.mdpi.com/1422-0067/22/19/10585
Autor:
Keith M. Channon, Surawee Chuaiphichai, Gillian Douglas, Lucy Trelfa, Lucy Donovan, Edward Drydale, Theodosios Kyriakou, Ioannis Akoumianakis, Charalambos Antoniades, Anuj Goel, Vedanta Mehta, Ayman Al Haj Zen, Ellie Tzima, Hugh Watkins, Victoria S Rashbrook
Publikováno v:
Cardiovascular Research
INTRODUCTION: Genome Wide Association studies have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fd437a428577a223bed4042c83aa09
http://europepmc.org/articles/PMC7449560
http://europepmc.org/articles/PMC7449560
Autor:
Daniel Ebner, Alison Howarth, Andrea Caporali, Andrea Martello, Marco Meloni, Ayman Al Haj Zen, David Mellis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 29-43 (2018)
Martello, A, Mellis, D, Meloni, M, Howarth, A, Ebner, D, Caporali, A & Al Haj Zen, A 2018, ' Phenotypic miRNA Screen Identifies miR-26b to Promote the Growth and Survival of Endothelial Cells ', Molecular Therapy-Nucleic Acids, vol. 13, pp. 29-43 . https://doi.org/10.1016/j.omtn.2018.08.006
Martello, A, Mellis, D, Meloni, M, Howarth, A, Ebner, D, Caporali, A & Al Haj Zen, A 2018, ' Phenotypic miRNA Screen Identifies miR-26b to Promote the Growth and Survival of Endothelial Cells ', Molecular Therapy-Nucleic Acids, vol. 13, pp. 29-43 . https://doi.org/10.1016/j.omtn.2018.08.006
Endothelial cell (EC) proliferation is a crucial event in physiological and pathological angiogenesis. MicroRNAs (miRNAs) have emerged as important modulators of the angiogenic switch. Here we conducted high-content screening of a human miRNA mimic l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db8bf656da49ac37bf59faca79cfc11
http://www.sciencedirect.com/science/article/pii/S2162253118302117
http://www.sciencedirect.com/science/article/pii/S2162253118302117
Autor:
Kerrie L. Ford, Andrea Caporali, Maryam Anwar, Graciela B. Sala-Newby, Marco Meloni, Micol Marchetti, Costanza Emanueli, Sadie C. Slater, Ayman Al Haj Zen
Publikováno v:
International Journal of Molecular Sciences
Marchetti, M, Meloni, M, Anwar, M, Zen, A A H, Sala-Newby, G, Slater, S, Ford, K, Caporali, A & Emanueli, C 2020, ' MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles ', International Journal of Molecular Sciences, vol. 21, no. 5 . https://doi.org/10.3390/ijms21051733
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1733 (2020)
Marchetti, M, Meloni, M, Anwar, M, Zen, A A H, Sala-Newby, G, Slater, S, Ford, K, Caporali, A & Emanueli, C 2020, ' MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles ', International Journal of Molecular Sciences, vol. 21, no. 5 . https://doi.org/10.3390/ijms21051733
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1733 (2020)
MicroRNAs (miRs) regulate complex processes, including angiogenesis, by targeting multiple mRNAs. miR-24-3p-3p directly represses eNOS, GATA2, and PAK4 in endothelial cells (ECs), thus inhibiting angiogenesis during development and in the infarcted h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f602f7cf81e2f09d8e97cda5dbb84178
http://europepmc.org/articles/PMC7084374
http://europepmc.org/articles/PMC7084374