Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ayman Abouzayed"'
Autor:
Ábel Nagy, Ayman Abouzayed, Panagiotis Kanellopoulos, Fredrika Landmark, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova, Amelie Eriksson Karlström
Publikováno v:
ACS Omega, Vol 9, Iss 34, Pp 36122-36133 (2024)
Externí odkaz:
https://doaj.org/article/dc2f7274d12c4f95807ce77476a39d91
Autor:
Panagiotis Kanellopoulos, Ekaterina Bezverkhniaia, Ayman Abouzayed, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Publikováno v:
ACS Omega, Vol 9, Iss 16, Pp 18608-18616 (2024)
Externí odkaz:
https://doaj.org/article/8bd3eee7c173407384fe6aa1df17bb36
Autor:
Panagiotis Kanellopoulos, Adam Mattsson, Ayman Abouzayed, Karim Obeid, Berthold A. Nock, Vladimir Tolmachev, Theodosia Maina, Anna Orlova
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-19 (2024)
Abstract Background The gastrin-releasing peptide receptor (GRPR) has been extensively studied as a biomolecular target for peptide-based radiotheranostics. However, the lack of metabolic stability and the rapid clearance of peptide radioligands, inc
Externí odkaz:
https://doaj.org/article/637e1155b147456f8a59fd7e94ba6862
Autor:
Karim Obeid, Panagiotis Kanellopoulos, Ayman Abouzayed, Adam Mattsson, Vladimir Tolmachev, Berthold A. Nock, Theodosia Maina, Anna Orlova
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 513 (2024)
Gastrin-releasing peptide receptor (GRPR)-antagonists have served as motifs in the development of theranostic radioligands for prostate cancer. Our efforts have been focused on the development of radiolabeled RM26 (H-DPhe6–Gln7–Trp8–Ala9–Val1
Externí odkaz:
https://doaj.org/article/76e700bb020b4623bb32b8e8e73fddd6
Autor:
Ayman Abouzayed, Kamila Seitova, Fanny Lundmark, Vitalina Bodenko, Maryam Oroujeni, Vladimir Tolmachev, Ulrika Rosenström, Anna Orlova
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionProstate specific membrane antigen (PSMA), highly expressed in metastatic castration-resistant prostate cancer (mCRPC), is an established therapeutic target. Theranostic PSMA-targeting agents are widely used in patient management and has
Externí odkaz:
https://doaj.org/article/f29b75a246594fe3adfa12541146a888
Autor:
Ayman Abouzayed, Panagiotis Kanellopoulos, Alisa Gorislav, Vladimir Tolmachev, Theodosia Maina, Berthold A. Nock, Anna Orlova
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1134 (2023)
Radiolabeled gastrin-releasing peptide receptor (GRPR) antagonists have shown great promise for the theranostics of prostate cancer; however, their suboptimal metabolic stability leaves room for improvements. It was recently shown that the replacemen
Externí odkaz:
https://doaj.org/article/79181012fada4a63b12426352b6477b3
Autor:
Ayman Abouzayed, Jesper Borin, Fanny Lundmark, Anastasiya Rybina, Sophia Hober, Roman Zelchan, Vladimir Tolmachev, Vladimir Chernov, Anna Orlova
Publikováno v:
Diagnostics, Vol 13, Iss 9, p 1611 (2023)
Gastrin-releasing peptide receptors (GRPRs) are overexpressed in the majority of primary prostate tumors and in prostatic lymph node and bone metastases. Several GRPR antagonists were developed for SPECT and PET imaging of prostate cancer. We previou
Externí odkaz:
https://doaj.org/article/02fe51a2a8e4441ab4be28c99151bdfa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Molecular imaging of the gastrin-releasing peptide receptor (GRPR) could improve patient management in prostate cancer. This study aimed to produce gallium-66 (T½ = 9.5 h) suitable for radiolabeling, and investigate the imaging properties o
Externí odkaz:
https://doaj.org/article/5ebce39f0c744e379ae8a92a1728d417
Autor:
Sara S. Rinne, Wen Yin, Anna Mestre Borras, Ayman Abouzayed, Charles Dahlsson Leitao, Anzhelika Vorobyeva, John Löfblom, Stefan Ståhl, Anna Orlova, Torbjörn Gräslund
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1293 (2022)
Increasing evidence suggests that therapy targeting the human epidermal growth factor receptor 3 (HER3) could be a viable route for targeted cancer therapy. Here, we studied a novel drug conjugate, ZHER3-ABD-mcDM1, consisting of a HER3-targeting affi
Externí odkaz:
https://doaj.org/article/1b4f2bf682d34017b8552f583cac72d9
Autor:
Fanny Lundmark, Gustav Olanders, Sara Sophie Rinne, Ayman Abouzayed, Anna Orlova, Ulrika Rosenström
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1098 (2022)
Prostate-specific membrane antigen (PSMA) is overexpressed in the majority of prostate cancer cells and is considered to be an important target for the molecular imaging and therapy of prostate cancer. Herein, we present the design, synthesis, and ev
Externí odkaz:
https://doaj.org/article/42ee0b13d37d48cfbedd198fa981a7f1