Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Aylwyn Scally"'
Autor:
Maja P. Mattle-Greminger, Tugce Bilgin Sonay, Alexander Nater, Marc Pybus, Tariq Desai, Guillem de Valles, Ferran Casals, Aylwyn Scally, Jaume Bertranpetit, Tomas Marques-Bonet, Carel P. van Schaik, Maria Anisimova, Michael Krützen
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Integrating demography and adaptive evolution is pivotal to understanding the evolutionary history and conservation of great apes. However, little is known about the adaptive evolution of our closest relatives, in particular if an
Externí odkaz:
https://doaj.org/article/46fd2b4542f14eadb2810e6b6086bc5a
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009221 (2021)
Many complex genomic rearrangements arise through template switch errors, which occur in DNA replication when there is a transient polymerase switch to an alternate template nearby in three-dimensional space. While typically investigated at kilobase-
Externí odkaz:
https://doaj.org/article/078472b6f95643dda24d866afb125955
Autor:
Iain Mathieson, Aylwyn Scally
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008624 (2020)
Externí odkaz:
https://doaj.org/article/b2380359524c42a38110a266d4da05cf
Autor:
Vagheesh M. Narasimhan, Raheleh Rahbari, Aylwyn Scally, Arthur Wuster, Dan Mason, Yali Xue, John Wright, Richard C. Trembath, Eamonn R. Maher, David A. van Heel, Adam Auton, Matthew E. Hurles, Chris Tyler-Smith, Richard Durbin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Estimates of human mutation rates differ substantially based on the approach. Here, the authors present a multi-generational estimate from the autozygous segment in a non-European population that gives insight into the contribution of post-zygotic mu
Externí odkaz:
https://doaj.org/article/be066eba4bc04f5e95c7ffd6d2e23463
Autor:
Laurits Skov, Ruoyun Hui, Vladimir Shchur, Asger Hobolth, Aylwyn Scally, Mikkel Heide Schierup, Richard Durbin
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007641 (2018)
Human populations outside of Africa have experienced at least two bouts of introgression from archaic humans, from Neanderthals and Denisovans. In Papuans there is prior evidence of both these introgressions. Here we present a new approach to detect
Externí odkaz:
https://doaj.org/article/619566d47fe94e70baaf5f9bba9a53cd
Autor:
Aylwyn Scally
Publikováno v:
eLife, Vol 6 (2017)
An analysis of worldwide human genetic variation reveals the footprints of ancient changes in genomic mutation processes.
Externí odkaz:
https://doaj.org/article/0451181a5a8c48b0a678c28ce36886a1
Autor:
Cathal Seoighe, Aylwyn Scally
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006549 (2017)
The rate of germline mutation varies widely between species but little is known about the extent of variation in the germline mutation rate between individuals of the same species. Here we demonstrate that an allele that increases the rate of germlin
Externí odkaz:
https://doaj.org/article/e66b21a578c4457299fcbf3bceb005ec
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65066 (2013)
All non-human great apes are endangered in the wild, and it is therefore important to gain an understanding of their demography and genetic diversity. Whole genome assembly projects have provided an invaluable foundation for understanding genetics in
Externí odkaz:
https://doaj.org/article/c8af7ec59cd14aec9e53e983430148bd
Autor:
Thomas Mailund, Anders E Halager, Michael Westergaard, Julien Y Dutheil, Kasper Munch, Lars N Andersen, Gerton Lunter, Kay Prüfer, Aylwyn Scally, Asger Hobolth, Mikkel H Schierup
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003125 (2012)
We present a hidden Markov model (HMM) for inferring gradual isolation between two populations during speciation, modelled as a time interval with restricted gene flow. The HMM describes the history of adjacent nucleotides in two genomic sequences, s
Externí odkaz:
https://doaj.org/article/22d1410b2ee74170b1496441aaac880c
De novo mutations (DNMs) in the germline have long been identified as a key element in the causes of developmental and other genetic disorders. Previous attempts to investigate genetic factors affecting DNMs have suffered from a lack of statistical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ffe82b718d3a28c15934b7d33580da
https://doi.org/10.1101/2022.12.17.520885
https://doi.org/10.1101/2022.12.17.520885