Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Aylwin Ng"'
Autor:
Kritika Ramani, Taylor Cormack, Adam N. R. Cartwright, Aula Alami, Pooja Parameswaran, Marynawal Abdou, Iris Wang, Kristie Hilliard-Barth, Shannon Argueta, Divya Raghunathan, Will Caffry, Christopher J. H. Davitt, Fabian B. Romano, Aylwin Ng, Valeria Kravitz, Tyler Rommel, Maria Sizova, Esra Uckun Kiran, Pallavi Pradeep, Holly E. Ponichtera, Tanmoy Ganguly, Mark Bodmer, Andrea Itano
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The gastrointestinal tract represents one of the largest body surfaces that is exposed to the outside world. It is the only mucosal surface that is required to simultaneously recognize and defend against pathogens, while allowing nutrients containing
Externí odkaz:
https://doaj.org/article/b106e0454a704b4281ad9b357e8fb702
Autor:
Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae-Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF
Externí odkaz:
https://doaj.org/article/fcfe5f0cdf014198b141e4fc270fc775
Autor:
Jakob Begun, Kara G. Lassen, Humberto B. Jijon, Leigh A. Baxt, Gautam Goel, Robert J. Heath, Aylwin Ng, Jenny M. Tam, Szu-Yu Kuo, Eduardo J. Villablanca, Lola Fagbami, Marije Oosting, Vinod Kumar, Monica Schenone, Steven A. Carr, Leo A.B. Joosten, Jatin M. Vyas, Mark J. Daly, Mihai G. Netea, Gordon D. Brown, Cisca Wijmenga, Ramnik J. Xavier
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1905-1918 (2015)
The polymorphism ATG16L1 T300A, associated with increased risk of Crohn’s disease, impairs pathogen defense mechanisms including selective autophagy, but specific pathway interactions altered by the risk allele remain unknown. Here, we use perturba
Externí odkaz:
https://doaj.org/article/5de71e4dd27c4fe482ae1576b02a0762
Autor:
Jian Zhu, Teresa Davoli, Jill M. Perriera, Christopher R. Chin, Gaurav D. Gaiha, Sinu P. John, Frederic D. Sigiollot, Geng Gao, Qikai Xu, Hongjing Qu, Thomas Pertel, Jennifer S. Sims, Jennifer A. Smith, Richard E. Baker, Louise Maranda, Aylwin Ng, Stephen J. Elledge, Abraham L. Brass
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 752-766 (2014)
RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and false negatives. To ameliorate these issues, we combined information from the
Externí odkaz:
https://doaj.org/article/b80c3f7209634aecb2d5e9756a0d87f6
Autor:
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler
Publikováno v:
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://doaj.org/article/740ed0340cbe47708079afcf989db0dd
Autor:
Martin Etzrodt, Virna Cortez-Retamozo, Andita Newton, Jimmy Zhao, Aylwin Ng, Moritz Wildgruber, Pedro Romero, Thomas Wurdinger, Ramnik Xavier, Frederic Geissmann, Etienne Meylan, Matthias Nahrendorf, Filip K. Swirski, David Baltimore, Ralph Weissleder, Mikael J. Pittet
Publikováno v:
Cell Reports, Vol 1, Iss 4, Pp 317-324 (2012)
Monocytes serve as a central defense system against infection and injury but can also promote pathological inflammatory responses. Considering the evidence that monocytes exist in at least two subsets committed to divergent functions, we investigated
Externí odkaz:
https://doaj.org/article/219d87c7f6b94359a6887a828de5218b
Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
Autor:
Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8 Article number: 15865 (2017); Published: 28 June 2017; Updated: 18 August 2017 The previously published version of this Article contained a line number in the Abstract within the sentence ‘A fraction of RIP2 localizes to the
Externí odkaz:
https://doaj.org/article/ddffffb5080b4efba26d0571887e537d
Autor:
Kathrin Buffen, Marije Oosting, Jessica Quintin, Aylwin Ng, Johanneke Kleinnijenhuis, Vinod Kumar, Esther van de Vosse, Cisca Wijmenga, Reinout van Crevel, Egbert Oosterwijk, Anne J Grotenhuis, Sita H Vermeulen, Lambertus A Kiemeney, Frank L van de Veerdonk, Georgios Chamilos, Ramnik J Xavier, Jos W M van der Meer, Mihai G Netea, Leo A B Joosten
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004485 (2014)
The anti-tuberculosis-vaccine Bacillus Calmette-Guérin (BCG) is the most widely used vaccine in the world. In addition to its effects against tuberculosis, BCG vaccination also induces non-specific beneficial effects against certain forms of maligna
Externí odkaz:
https://doaj.org/article/1f267804eb5843b3ae7bd69978fd754d
Autor:
Daniel Baird, John H. Brumell, Kirsty Hooper, Leon Murphy, Jonathan M. Goodwin, Jeff Saunders, Sreekanth R. Rouduri, Sravya Kommineni, Archana Jha, Aylwin Ng, Oliver Florey, Menghao Wei, Taoyingnan Li, Mark R. Chance, Ward G. Walkup, Timothy Lehmberg, Sagar R. Budhe, Qing Tang, Jorge Garcia-Fortanet, Yaya Fan, Asmita Agrawal, Katherine Fletcher, Brent A. Appleton, Andrea Ballabio, Chieko Kishi-Itakura, Janna Kiselar
Publikováno v:
Science Advances. 7
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation are unclear. LC3 and GABARAP members of the
Autor:
Xueqiao Jiang, Manolis Kellis, Hansruedi Mathys, Shahin Mohammadi, Jose Davila-Velderrain, Li-Huei Tsai, David A. Bennett, Brad Ruzicka, Aylwin Ng
The human hippocampal formation plays a central role in Alzheimer’s disease (AD) progression, cognitive traits, and the onset of dementia; yet its molecular states in AD remain uncharacterized. Here, we report a comprehensive single-cell transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8737afb6ebd92451c7784682dfdfc3b8
https://doi.org/10.1101/2021.07.01.450715
https://doi.org/10.1101/2021.07.01.450715