Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Aylin R, Rodan"'
Autor:
Nader H. Mahmoudzadeh, Yasaman Heidarian, Jason P. Tourigny, Alexander J. Fitt, Katherine Beebe, Hongde Li, Arthur Luhur, Kasun Buddika, Liam Mungcal, Anirban Kundu, Robert A. Policastro, Garrett J. Brinkley, Gabriel E. Zentner, Travis Nemkov, Robert Pepin, Geetanjali Chawla, Sunil Sudarshan, Aylin R. Rodan, Angelo D'Alessandro, Jason M. Tennessen
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102013- (2024)
Objectives: The mitochondrial enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) regulates the abundance of L-2-hydroxyglutarate (L-2HG), a potent signaling metabolite capable of influencing chromatin architecture, mitochondrial metabolism, and cell
Externí odkaz:
https://doaj.org/article/c959551a1a6c44d4a4238d794febab0c
Evaluation of renal sodium handling in heart failure with preserved ejection fraction: A pilot study
Autor:
Adhish Agarwal, Srinivasan Beddhu, Robert Boucher, Veena Rao, Nirupama Ramkumar, Aylin R. Rodan, Jacob Fang, Brandi M. Wynne, Stavros G. Drakos, Thomas Hanff, Alfred K. Cheung, James C. Fang
Publikováno v:
Physiological Reports, Vol 12, Iss 9, Pp n/a-n/a (2024)
Abstract The pathophysiology behind sodium retention in heart failure with preserved ejection fraction (HFpEF) remains poorly understood. We hypothesized that patients with HFpEF have impaired natriuresis and diuresis in response to volume expansion
Externí odkaz:
https://doaj.org/article/9ffcb949c276407eb186eebff289d4e5
Autor:
Prathibha Yarikipati, Sima Jonusaite, John M Pleinis, Carihann Dominicci Cotto, David Sanchez-Hernandez, Daryl E Morrison, Suhani Goyal, Jeffrey Schellinger, Clothilde Pénalva, Jennifer Curtiss, Aylin R Rodan, Andreas Jenny
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010975 (2023)
WNK (With no Lysine [K]) kinases have critical roles in the maintenance of ion homeostasis and the regulation of cell volume. Their overactivation leads to pseudohypoaldosteronism type II (Gordon syndrome) characterized by hyperkalemia and high blood
Externí odkaz:
https://doaj.org/article/b6adfc2ea48b4ecd889356660b33c85a
Autor:
Collin B. Merrill, Austin B. Montgomery, Miguel A. Pabon, Andrey A. Shabalin, Aylin R. Rodan, Adrian Rothenfluh
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Gene regulation is critical for proper cellular function. Next-generation sequencing technology has revealed the presence of regulatory networks that regulate gene expression and essential cellular functions. Studies investigating
Externí odkaz:
https://doaj.org/article/9c6a6656befe4806903a1fb4a4db4f16
Autor:
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mitochondrial complex I deficiency is frequent in congenital, neurologic and cardiovascular disease. Here the authors demonstrate that Complex I stimulates the turnover of a mitochondrial calcium channel, which becomes stabilized during Complex I def
Externí odkaz:
https://doaj.org/article/c2ef9f77a9ef4d22aad9d8b4d27239a7
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Assay for transposase-accessible chromatin by sequencing (ATAC-seq) is rapidly becoming the assay of choice to investigate chromatin-mediated gene regulation, largely because of low input requirements, a fast workflow, and the ability to int
Externí odkaz:
https://doaj.org/article/ea7966fff2d942ddae05515757729597
Autor:
Puskar Mishra, Shany E. Yang, Austin B. Montgomery, Addison R. Reed, Aylin R. Rodan, Adrian Rothenfluh
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Proper regulation of feeding is important for an organism’s well-being and survival and involves a motivational component directing the search for food. Dissecting the molecular and neural mechanisms of motivated feeding behavio
Externí odkaz:
https://doaj.org/article/7237a38c1e8f426e8b64b27b0e3b498c
Autor:
Kelly A. Hyndman, Elena Isaeva, Oleg Palygin, Luciano D. Mendoza, Aylin R. Rodan, Alexander Staruschenko, Jennifer S. Pollock
Publikováno v:
Physiological Reports, Vol 9, Iss 20, Pp n/a-n/a (2021)
Abstract The nitric oxide (NO)‐generating enzyme, NO synthase‐1β (NOS1β), is essential for sodium (Na+) homeostasis and blood pressure control. We previously showed that collecting duct principal cell NOS1β is critical for inhibition of the ep
Externí odkaz:
https://doaj.org/article/9fc56951e59441bfb00452897d4b5cca
Autor:
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/375509dbb57e4c128813f2aea63a1296
Autor:
Dana M Talsness, Katie G Owings, Emily Coelho, Gaelle Mercenne, John M Pleinis, Raghavendran Partha, Kevin A Hope, Aamir R Zuberi, Nathan L Clark, Cathleen M Lutz, Aylin R Rodan, Clement Y Chow
Publikováno v:
eLife, Vol 9 (2020)
N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears. To model the phenotypic variab
Externí odkaz:
https://doaj.org/article/b15615d75fd24af79e4e3c0481b7aa57