Association of region‐specific hippocampal reduction of neurogranin with inflammasome proteins in post mortem brains of Alzheimer's disease

Autor: Regina T. Vontell, Ryan Gober, Julian Dallmeier, Daniel Brzostowicki, Ayled Barreda, Kaj Blennow, Henrik Zetterberg, Hlin Kvartsberg, Sakir Humayun Gultekin, Juan Pablo deRivero Vaccari, Helen M. Bramlett, W. Dalton Dietrich, Robert W. Keane, David A. Davis, Tatjana Rundek, Xiaoyan Sun

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)

Abstract INTRODUCTION Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology. METHODS We investigated the protein expression, mo

Externí odkaz: https://doaj.org/article/b004ddac02d747e7a1752bb243a63c79

Microglia activation in postmortem brains with schizophrenia demonstrates distinct morphological changes between brain regions

Autor: Maryam Ardalan, Seyedeh Marziyeh Jabbari Shiadeh, Susanna P. Garamszegi, Carina Mallard, Ayled Barreda, Ryan Gober, Regina Vontell, Xiaoyan Sun, Maureen C. Ascona, Linda Duque

Publikováno v: Brain Pathology
Gober, R, Ardalan, M, Jabbari, M, Duque, L, P. Garamszegi, S, Ascona, M, Barreda, A, Sun, X, Mallard, C & T. Vontell, R 2022, ' Microglia activation in postmortem brains with schizophrenia demonstrates distinct morphological changes between brain regions ', Brain Pathology, vol. 32, no. 1, e13003 . https://doi.org/10.1111/bpa.13003

Schizophrenia (SCZ) is a psychiatric disorder that can include symptoms of disorganized speech and thoughts with uncertain underlying mechanisms possibly linked to over‐activated microglia. In this study, we used brain samples from sixteen donors w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2199715e802f103cd3b75fcd5451464
https://pubmed.ncbi.nlm.nih.gov/34297453