Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ayla Smout"'
Autor:
Vincent De Smet, Elif Gürbüz, Nathalie Eysackers, Liza Dewyse, Ayla Smout, Mina Kazemzadeh Dastjerd, Pierre Lefesvre, Nouredin Messaoudi, Hendrik Reynaert, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101036- (2024)
Background & Aims: Chronic liver disease (CLD) remains a global health issue associated with a significant disease burden. Liver fibrosis, a hallmark of CLD, is characterised by the activation of hepatic stellate cells (HSCs) that gain profibrotic ch
Externí odkaz:
https://doaj.org/article/a220db56f1c24cd99ae3f6a1a5825e81
Autor:
Jonathan De Smedt, Elise Anne van Os, Irene Talon, Sreya Ghosh, Burak Toprakhisar, Rodrigo Furtado Madeiro Da Costa, Samantha Zaunz, Marta Aguirre Vazquez, Ruben Boon, Pieter Baatsen, Ayla Smout, Stefaan Verhulst, Leo A. van Grunsven, Catherine M. Verfaillie
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth factors can induce an LSEC fate in (pluripoten
Externí odkaz:
https://doaj.org/article/a72ccbfa4b2f428e822457e0c7616dda
Autor:
Elise Anne van Os, Laura Cools, Nathalie Eysackers, Karolina Szafranska, Ayla Smout, Stefaan Verhulst, Hendrik Reynaert, Peter McCourt, Inge Mannaerts, Leo A. van Grunsven
Chronic liver disease can lead to liver fibrosis and ultimately cirrhosis, which is a significant health burden and a major cause of death worldwide. Reliable in vitro models are lacking and thus mono-cultures of cell lines are still used to study li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5809b81c528e771169773caaaa25965e
https://doi.org/10.1016/j.biomaterials.2022.121817
https://doi.org/10.1016/j.biomaterials.2022.121817
Autor:
Teresa Rubio-Tomás, Catherine M. Verfaillie, Pau Sancho-Bru, Beatriz Aguilar-Bravo, Leo A. van Grunsven, Julia Vallverdú, Silvia Ariño, Stefaan Verhulst, Celia Martínez-Sánchez, Mar Coll, Raquel A Martínez García de la Torre, Ayla Smout, Inge Mannaerts, Delia Blaya
Publikováno v:
Nature Protocols
Hepatic stellate cells (HSCs) are nonparenchymal liver cells responsible for extracellular matrix homeostasis and are the main cells involved in the development of liver fibrosis following injury. The lack of reliable sources of HSCs has hence limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189786e7a5866486e093a44942bd2cf8
https://hdl.handle.net/20.500.14017/21df6101-bec0-4a4b-8ace-c78304ed65db
https://hdl.handle.net/20.500.14017/21df6101-bec0-4a4b-8ace-c78304ed65db
Autor:
Leo A. van Grunsven, Stefaan Verhulst, Irene Talon, Catherine M. Verfaillie, Jonathan De Smedt, Ruben Boon, Sreya Ghosh, Samantha Zaunz, Marta Aguirre Vazquez, Rodrigo Furtado Madeiro Da Costa, Burak Toprakhisar, Pieter Baatsen, Ayla Smout, Elise Anne van Os
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 1, Pp 1-18 (2021)
Cell Death and Disease, Vol 12, Iss 1, Pp 1-18 (2021)
To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth factors can induce an LSEC fate in (pluripotent stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff8d437b1de63b07b67260501bd5835
https://doi.org/10.1101/2020.08.10.244517
https://doi.org/10.1101/2020.08.10.244517
Autor:
Sofia B. Leite, Ayla Smout, Inge Mannaerts, Olivier Frey, Stefaan Verhulst, Elise Anne van Os, Nathalie Eysackers, Leo A. van Grunsven, Andreas Hierlemann, T. Roosens
Publikováno v:
Biomaterials. 261
A major obstacle in the development of efficient therapies for progressive liver fibrosis is the lack of representative in vitro models of liver fibrosis to aid in understanding the mechanisms of the disease and to promote the development of pharmace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c74977500c63126816b0c416831417f
https://pubmed.ncbi.nlm.nih.gov/32891040
https://pubmed.ncbi.nlm.nih.gov/32891040
Autor:
Ayla Smout, Adil El Taghdouini, Inge Mannaerts, Ruben Boon, Leo A. van Grunsven, Isabel Graupera, Beatriz Aguilar-Bravo, Daniel Rodrigo-Torres, Juan José Lozano, Christophe Chesne, Pau Sancho-Bru, Catherine M. Verfaillie, Etienne Sokal, Julia Vallverdú, Delia Blaya, L. Perea, Mar Coll, Sofia B. Leite, Mustapha Najimi
Publikováno v:
Cell Stem Cell
Cell stem cell, Vol. 23, no.1, p. 101-113.e7 (2018)
Cell stem cell, Vol. 23, no.1, p. 101-113.e7 (2018)
The development of complex in vitro hepatic systems and artificial liver devices has been hampered by the lack of reliable sources for relevant cell types, such as hepatic stellate cells (HSCs). Here we report efficient differentiation of human pluri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a1aabb97bce6b174d937188b16db61
https://lirias.kuleuven.be/handle/123456789/630098
https://lirias.kuleuven.be/handle/123456789/630098
Autor:
Fozia Noor, Mustapha Najimi, Ayla Smout, T. Roosens, Inge Mannaerts, Christophe Chesne, Sofia B. Leite, Adil El Taghdouini, Etienne Sokal, Leo A. van Grunsven
Publikováno v:
Biomaterials. 78
Current models for in vitro fibrosis consist of simple mono-layer cultures of rodent hepatic stellate cells (HSC), ignoring the role of hepatocyte injury. We aimed to develop a method allowing the detection of hepatocyte-mediated and drug-induced liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef952b25771295ebb74ed31059c5fbce
https://pubmed.ncbi.nlm.nih.gov/26618472
https://pubmed.ncbi.nlm.nih.gov/26618472