Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ayla O. Manughian-Peter"'
Autor:
Javier I. J. Orozco, Theo A. Knijnenburg, Ayla O. Manughian-Peter, Matthew P. Salomon, Garni Barkhoudarian, John R. Jalas, James S. Wilmott, Parvinder Hothi, Xiaowen Wang, Yuki Takasumi, Michael E. Buckland, John F. Thompson, Georgina V. Long, Charles S. Cobbs, Ilya Shmulevich, Daniel F. Kelly, Richard A. Scolyer, Dave S. B. Hoon, Diego M. Marzese
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of meta
Externí odkaz:
https://doaj.org/article/48d7f470aacb41c6b7ae96cfd0196169
Autor:
John R. Jalas, Diego M. Marzese, Miquel Ensenyat-Mendez, Matthew P. Salomon, Ayla O. Manughian-Peter, Javier I. J. Orozco, Maggie L. DiNome, Shu-Ching Chang, Chikako Matsuba
Publikováno v:
Annals of Surgical Oncology. 26:3344-3353
Triple-negative breast cancer (TNBC) is a heterogeneous collection of breast tumors with numerous differences including morphological characteristics, genetic makeup, immune-cell infiltration, and response to systemic therapy. DNA methylation profili
Autor:
Diego M. Marzese, Javier I. J. Orozco, Grace Chang, Shu-Ching Chang, Francisco E. Gago, Matthew P. Salomon, Ayla O. Manughian-Peter, Chikako Matsuba, Janie G. Grumley
Publikováno v:
Annals of Surgical Oncology. 26:3185-3193
Pathological response to neoadjuvant chemotherapy (NAC) is critical in prognosis and selection of systemic treatments for patients with triple-negative breast cancer (TNBC). The aim of this study is to identify gene expression-based markers to predic
Autor:
James S. Wilmott, Ayla O. Manughian-Peter, Diego M. Marzese, Yuki Takasumi, Daniel F. Kelly, Ilya Shmulevich, Matthew P. Salomon, John R. Jalas, Javier I. J. Orozco, Garni Barkhoudarian, Dave S.B. Hoon, Xiaowen Wang, John F. Thompson, Charles Cobbs, Georgina V. Long, Theo A. Knijnenburg, Richard A. Scolyer, Michael E. Buckland, Parvinder Hothi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Optimal treatment of brain metastases is often hindered by limitations in diagnostic capabilities. To meet this challenge, here we profile DNA methylomes of the three most frequent types of brain metastases: melanoma, breast, and lung cancers (n = 96
Publikováno v:
Clinical & Experimental Metastasis. 35:393-402
Metastatic cells exhibit an extraordinary phenotypic plasticity, not only in adapting to unfamiliar microenvironments but also in surviving aggressive treatments and immune responses. A major source of phenotypic variability is alternative splicing (
Publikováno v:
Epigenetics Insights, Vol 12 (2019)
Epigenetics Insights
Epigenetics Insights
DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify the tissue of origin of a wide range of benign and malignant neoplasms. Using microarray-based profiling and supervised machine learning algorithms,
Autor:
Diego M. Marzese, James S. Wilmott, Javier I. J. Orozco, Richard A. Scolyer, Charles Cobbs, Matthew P. Salomon, Dave S.B. Hoon, Parvinder Hothi, Ayla O. Manughian-Peter
Publikováno v:
Scientific Data
Brain metastases (BM) are one the most lethal and poorly managed clinical complications in cancer patients. These secondary tumors represent the most common intracranial neoplasm in adults, most frequently originating from lung cancer, breast cancer,
Autor:
Matthew P. Salomon, Ayla O. Manughian-Peter, Dave S.B. Hoon, Steven J. O'Day, Javier I. J. Orozco, Diego M. Marzese
Publikováno v:
Journal of Clinical Oncology. 36:1096-1096
1096Background: Immunotherapy has shown promising results in enhancing response rates for patients with triple-negative breast cancer (TNBC). The success of immunotherapy is affected by poor tumor ...