Intercalated amygdala clusters orchestrate a switch in fear state

Autor: Chase A. Weinholtz, Mathias Mahn, Martin Zeller, Andrew Holmes, Tanner Rigg, Ingrid Ehrlich, Aaron Limoges, Tiffany Campbell, Nikolaos Karalis, Olena Bukalo, Adriana Mendez, Andreas Lüthi, Kenta M. Hagihara, Larry S. Zweifel, Richard D. Palmiter, Ayla Aksoy-Aksel

Publikováno v: Nature

Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive and persistent reactions to perceived threat, as can occur in anxiety and ‘traum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1c2b46b0b7ba592a519ccbb7cb5d53
https://doi.org/10.1038/s41586-021-03593-1

Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms

Autor: Francesco Ferraguti, Ayla Aksoy-Aksel, Ingrid Ehrlich, Andrea Gall, Anna Seewald

Dopaminergic signaling plays an important role in associative learning including fear and extinction learning. Dopaminergic midbrain neurons encode prediction error-like signals when threats differ from expectations. Within the amygdala, GABAergic in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27794c0b4e992215e6e1dfec0f9c780e
https://doi.org/10.1101/2020.10.29.360750

Studying Neuronal Function Ex Vivo Using Optogenetic Stimulation and Patch Clamp

Autor: Ayla, Aksoy-Aksel, Julien, Genty, Martin, Zeller, Ingrid, Ehrlich

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2173

Optogenetics has become a key method to interrogate the function of neural populations and circuits in the brain. This technique combines the targeted expression of light-activated proteins with subsequent manipulation of neural activity by light. Op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2415debf480a20ced10ca933169f24d2
https://pubmed.ncbi.nlm.nih.gov/32651907

A microRNA‐129‐5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses

Autor: Cristina R. Reschke, Ayla Aksoy-Aksel, Norman Delanty, Morten T. Venø, Thomas Braun, Sebastian Bauer, Braxton A. Norwood, Michael A. Farrell, Donncha F. O’Brien, Roberto Fiore, Franziska Metge, Christoph Dieterich, Rana Raoof, Silvia Bicker, Felix Rosenow, David C. Henshall, Gary P. Brennan, Gerhard Schratt, Marcus Krüger, Marek Rajman, Sharof Khudayberdiev, Jørgen Kjems

Publikováno v: Rajman, M, Metge, F, Fiore, R, Khudayberdiev, S, Aksoy-Aksel, A, Bicker, S, Reschke, C R, Raoof, R, Brennan, G P, Delanty, N, Farrell, M A, O'Brien, D F, Bauer, S, Norwood, B, Veno, M T, Krueger, M, Braun, T, Kjems, J, Rosenow, F, Henshall, D C, Dieterich, C & Schratt, G 2017, ' A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses ', E M B O Journal, vol. 36, no. 12, pp. 1770-1787 . https://doi.org/10.15252/embj.201695748

Synaptic downscaling is a homeostatic mechanism that allows neurons to reduce firing rates during chronically elevated network activity. Although synaptic downscaling is important in neural circuit development and epilepsy, the underlying mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fb481b7f9a93f21613c2cc0cffbd33
https://doi.org/10.15252/embj.201695748

A coding-independent function of an alternative Ube3a transcript during neuronal development

Autor: Roberto Fiore, Simon Sumer, Tatjana Wüst, Rainer K.W. Schwarting, Franziska Metge, Dominik Seffer, Markus Wöhr, Ayla Aksoy-Aksel, Silvia Bicker, Jeremy Valluy, Christoph Dieterich, Gerhard Schratt, Martin Lackinger

Publikováno v: Nature neuroscience. 18(5)

The E3 ubiquitin ligase Ube3a is an important regulator of activity-dependent synapse development and plasticity. Ube3a mutations cause Angelman syndrome and have been associated with autism spectrum disorders (ASD). However, the biological significa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2910d3c45d5e174e20965bca6c870313
https://pubmed.ncbi.nlm.nih.gov/25867122