Implications of the RhoA/Rho associated kinase pathway and leptin in primary uterine inertia in the dog

Autor: Bianca Lourdes FREHNER, Iris Margaret REICHLER, Mariusz Pawel KOWALEWSKI, Aykut GRAM, Stefanie KELLER, Sandra GOERICKE-PESCH, Orsolya BALOGH

Publikováno v: The Journal of Reproduction and Development, Vol 67, Iss 3, Pp 207-215 (2021)

The underlying functional and molecular changes in canine primary uterine inertia (PUI) are still not clarified. Leptin (Lep) and obesity negatively affect uterine contractility in women, partly mediated by the RhoA/Rho associated kinase pathway, aff

Externí odkaz: https://doaj.org/article/63d7b43881dd41a8a4d267532ebd6485

The Efficacy of a 3β-Hydroxysteroid Dehydrogenase Inhibitor for the Termination of Mid-Term Pregnancies in Dogs

Autor: Firdevs Binli, İpek İnan, Fatih Büyükbudak, Aykut Gram, Duygu Kaya, Narin Liman, Selim Aslan, Murat Fındık, Serhan Serhat Ay

Publikováno v: Animals, Vol 12, Iss 18, p 2475 (2022)

Progesterone (P4) is the only hormone needed to maintain pregnancy in dogs. Therefore, a competitive inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) could be a safe and effective option to terminate pregnancy by inhibiting P4 synthesis. To ad

Externí odkaz: https://doaj.org/article/f025c80c14c04702bbb1d4286c9d5180

Transcriptome analysis reveals differences in mechanisms regulating cessation of luteal function in pregnant and non-pregnant dogs

Autor: Sophie Zatta, Hubert Rehrauer, Aykut Gram, Alois Boos, Mariusz Pawel Kowalewski

Publikováno v: BMC Genomics, Vol 18, Iss 1, Pp 1-18 (2017)

Abstract Background In the domestic dog, corpora lutea (CL) are the only source of progesterone (P4), both in pregnant and non-pregnant cycles because there is no placental steroidogenesis. The absence of an endogenous luteolysin in absence of pregna

Externí odkaz: https://doaj.org/article/841985cfd4b04608bf14806472f98aa1

Canine Endotheliochorial Placenta: Morpho-Functional Aspects

Autor: Mariusz P, Kowalewski, Ali, Kazemian, Karl, Klisch, Tina, Gysin, Miguel, Tavares Pereira, Aykut, Gram

Publikováno v: Advances in anatomy, embryology, and cell biology. 234

In the domestic dog, placentation arises from central implantation, passing through a transitional, yet important stage of choriovitelline placenta (yolk sac placenta), on the way to the formation of the definite, deciduate, zonary (girdle) allantoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aabaf019c91452c903edc63f68c91d56
https://pubmed.ncbi.nlm.nih.gov/34694481

Implications of the RhoA/Rho associated kinase pathway and leptin in primary uterine inertia in the dog

Autor: Iris M Reichler, Sandra Goericke-Pesch, Aykut Gram, Orsolya Balogh, Mariusz P. Kowalewski, Stefanie Keller, Bianca Lourdes Frehner

Publikováno v: Frehner, B L, Reichler, I M, Kowalewski, M P, Gram, A, Keller, S, Goericke-Pesch, S & Balogh, O 2021, ' Implications of the RhoA/Rho associated kinase pathway and leptin in primary uterine inertia in the dog ', The Journal of reproduction and development, vol. 67, no. 3, pp. 207-215 . https://doi.org/10.1262/jrd.2020-141
The Journal of Reproduction and Development

The underlying functional and molecular changes in canine primary uterine inertia (PUI) are still not clarified. Leptin (Lep) and obesity negatively affect uterine contractility in women, partly mediated by the RhoA/Rho associated kinase pathway, aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729e43e473a32c98b8264691e8acbcbf
https://avesis.erciyes.edu.tr/publication/details/662b1ec7-2270-4b81-993f-52be694007bb/oai