Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ayinuer Adijiang"'
Autor:
Adekunle Alabi, Xiao-Dan Xia, Hong-Mei Gu, Faqi Wang, Shi-Jun Deng, Nana Yang, Ayinuer Adijiang, Donna N. Douglas, Norman M. Kneteman, Yazhuo Xue, Li Chen, Shucun Qin, Guiqing Wang, Da-Wei Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of M
Externí odkaz:
https://doaj.org/article/d72c4682bad4414eafe52c4f12f492db
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 516-527 (2019)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth fac
Externí odkaz:
https://doaj.org/article/20e22f29dc094509a2ae980a6bfa0d83
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 12, Pp 3345-3357 (2013)
Proprotein convertase subtilisin kexin-like 9 (PCSK9) promotes the degradation of low density lipoprotein receptor (LDLR) and plays an important role in regulating plasma LDL-cholesterol levels. We have shown that the epidermal growth factor precurso
Externí odkaz:
https://doaj.org/article/61a7481240244ad49016a38668aec78a
Autor:
Yun-Hee Youm, Thirumala-Devi Kanneganti, Bolormaa Vandanmagsar, Xuewei Zhu, Anthony Ravussin, Ayinuer Adijiang, John S. Owen, Michael J. Thomas, Joseph Francis, John S. Parks, Vishwa Deep Dixit
Publikováno v:
Cell Reports, Vol 1, Iss 1, Pp 56-68 (2012)
The collapse of thymic stromal cell microenvironment with age and resultant inability of the thymus to produce naive T cells contributes to lower immune-surveillance in the elderly. Here we show that age-related increase in ‘lipotoxic danger signal
Externí odkaz:
https://doaj.org/article/f9d8dd1e07604e16b972348743bc0403
Autor:
Nadia Maarouf, Ayinuer Adijiang, Jingti Deng, Yong Xiang Chen, Zarah Batulan, Annegret Ulke-Lemée, Sonya Bharadwa, Vipul Shrivastava, William T. Gerthoffer, Jonathan L.E. Dean, Chunhua Shi, F. Daniel Ramirez, Alexandria Hellmich, Catherine Diao, Brenig Gwilym, Angie A. Hu, Jingwen Liu, Matthew Rosin, Edward R. O'Brien, Christopher Malozzi
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Elevated HSP27 (heat shock protein 27) levels predict relative freedom from cardiovascular events. Over-expression or twice daily subcutaneous injections of human HSP27 in ApoE −/− mice reduces blood and plaque cholesterol levels, as w
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 516-527 (2019)
Journal of Lipid Research
Journal of Lipid Research
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth fac
Autor:
Donna N. Douglas, Ayinuer Adijiang, Shucun Qin, Adekunle Alabi, Guiqing Wang, Li Chen, Nana Yang, Shijun Deng, Hong-mei Gu, Norman M. Kneteman, Da-Wei Zhang, Faqi Wang, Xiao-Dan Xia, Yazhuo Xue
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Plasma low-density lipoprotein (LDL) is primarily cleared by LDL receptor (LDLR). LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into extracellular milieu. However, the proteinase responsible for LDLR cleavage is unknow
Autor:
William T. Gerthoffer, Sonya Bharadwa, Yong-Xiang Chen, Angie Hu, Chunhua Shi, Vipul Shrivastava, Jingwen Liu, Annegret Ulke-Lemée, Edward R. O'Brien, Ayinuer Adijiang, Brenig Llwyd Gwilym, Zarah Batulan, Matthew Rosin, Jingti Deng, Alexandria Hellmich, F. Daniel Ramirez, Christopher Malozzi, Jonathan L.E. Dean, Catherine Diao, Nadia Maarouf
Elevated Heat Shock Protein 27 levels predict relative freedom from cardiovascular events. In ApoE-/- mice HSP27 over-expression or twice daily subcutaneous injections reduce blood and plaque cholesterol levels, inflammation and atherogenesis. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8be053f6419227269d8dc11970508f6
https://doi.org/10.1101/2020.05.21.102350
https://doi.org/10.1101/2020.05.21.102350
Autor:
Chunhua Shi, Tara Seibert, Zarah Batulan, Yong Xiang Chen, Edward R. O'Brien, Vivek Krishna Pulakazhi Venu, Ayinuer Adijiang
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(6)
Recently, we demonstrated that heat shock protein (HSP)-27 is protective against the development of experimental atherosclerosis, reducing plaque cholesterol content by more than 30%. Moreover, elevated HSP-27 levels are predictive of relative freedo
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 12, Pp 3345-3357 (2013)
Proprotein convertase subtilisin kexin-like 9 (PCSK9) promotes the degradation of low density lipoprotein receptor (LDLR) and plays an important role in regulating plasma LDL-cholesterol levels. We have shown that the epidermal growth factor precurso