A rare human variant that disrupts GPR10 signalling causes weight gain in mice

Autor: Fleur Talbot, Claire H. Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M. Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S. H. Yeo, Philippe Froguel, David A. Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M. Luckman, I. Sadaf Farooqi

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

The brain-expressed receptor GPR10 is involved in energy homeostasis in mice. Here the authors identify rare loss of function variants in GPR10 in people with severe obesity and showed that one of these variants causes obesity when modelled in mice,

Externí odkaz: https://doaj.org/article/ae488579c70a4e4895c6b257ff54f30c

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

Autor: Brouwers, Bas, de Oliveira, Edson Mendes, Marti-Solano, Maria, Monteiro, Fabiola B.F., Laurin, Suli-Anne, Keogh, Julia M., Henning, Elana, Bounds, Rebecca, Daly, Carole A., Houston, Shane, Ayinampudi, Vikram, Wasiluk, Natalia, Clarke, David, Plouffe, Bianca, Bouvier, Michel, Babu, M. Madan, Farooqi, I. Sadaf, Mokrosiński, Jacek

Publikováno v: In Cell Reports 23 March 2021 34(12)

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

Autor: Lotta, Luca A., Mokrosiński, Jacek, Mendes de Oliveira, Edson, Li, Chen, Sharp, Stephen J., Luan, Jian’an, Brouwers, Bas, Ayinampudi, Vikram, Bowker, Nicholas, Kerrison, Nicola, Kaimakis, Vasileios, Hoult, Diana, Stewart, Isobel D., Wheeler, Eleanor, Day, Felix R., Perry, John R.B., Langenberg, Claudia, Wareham, Nicholas J., Farooqi, I. Sadaf

Publikováno v: In Cell 18 April 2019 177(3):597-607

Relationship between hemoglobin levels and oral hygiene status in different trimesters of pregnancy – A cross-sectional study

Autor: Venkat Baghirath Pacha, Madhuri Mukhe, Hari Vinay Balisetty, P Parameswar Naishadham, Vijay Kumar Jogishetty, Bhargavi Krishna Ayinampudi

Publikováno v: Journal of Indian Association of Public Health Dentistry, Vol 17, Iss 4, Pp 337-340 (2019)

Background: Pregnancy is a phase which has gained much attention due to the physiological changes taking place, of which the oral health is of utmost importance as it may pose difficulties in birth outcomes. Aim: This study aims to evaluate the oral

Externí odkaz: https://doaj.org/article/8bfdb18aa01d427fbf1c024e61d95bd5

A rare human variant that disrupts GPR10 signalling causes weight gain in mice

Autor: Talbot, Fleur, Feetham, Claire H, Mokrosiński, Jacek, Lawler, Katherine, Keogh, Julia M, Henning, Elana, Mendes De Oliveira, Edson, Ayinampudi, Vikram, Saeed, Sadia, Bonnefond, Amélie, Arslan, Mohammed, Yeo, Giles S H, Froguel, Philippe, Bechtold, David A, Adamson, Antony, Humphreys, Neil, Barroso, Inês, Luckman, Simon M, Farooqi, I Sadaf

Publikováno v: Talbot, F, Feetham, C H, Mokrosiński, J, Lawler, K, Keogh, J M, Henning, E, Mendes de Oliveira, E, Ayinampudi, V, Saeed, S, Bonnefond, A, Arslan, M, Yeo, G S H, Froguel, P, Bechtold, D A, Adamson, A, Humphreys, N, Barroso, I, Luckman, S M & Farooqi, I S 2023, ' A rare human variant that disrupts GPR10 signalling causes weight gain in mice ', Nature Communications, vol. 14, no. 1, 1450 . https://doi.org/10.1038/s41467-023-36966-3

Funder: Wellcome Trust
Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e435553c50799391cd56e6124180fb07
https://doi.org/10.1038/s41467-023-36966-3