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pro vyhledávání: '"Ayiesha Barnes"'
Autor:
Sanjay Khandelwal, Sooho Samuel Myoung, Jon T. Skare, Gowthami M. Arepally, Ayiesha Barnes, Samuel Francis, Charles Booth, Brandon L. Garcia, Lubica Rauova, Douglas B. Cines, Grace M. Lee, Simone Sartoretto
Publikováno v:
Blood. 138:2076-2076
Background: Recent studies show that ultra-large immune complexes consisting of IgG and platelet factor 4 and heparin (P+H) potently activate complement and facilitate complement dependent activation of cellular FcgRIIA (PMID 34189574). In whole bloo
Autor:
Mortimer Poncz, Douglas B. Cines, Ann H. Rux, Sanjay Khandelwal, Sooho Samuel Myoung, Gowthami M. Arepally, Serge Yarovoi, Lubica Rauova, Madelaine Duarte, Ayiesha Barnes, Alexandra Johnson, Grace M. Lee
Publikováno v:
Blood. 136:11-12
Heparin induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by ultra-large immune complexes (ULICs) containing IgG antibodies bound to multivalent complexes of platelet factor 4 (PF4) and heparin (H). HIT ULICs activate cellular FcγI