Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Aygul Subkhangulova"'
Autor:
Marieke Meijer, Miriam Öttl, Jie Yang, Aygul Subkhangulova, Avinash Kumar, Zicheng Feng, Torben W. van Voorst, Alexander J. Groffen, Jan R. T. van Weering, Yongli Zhang, Matthijs Verhage
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Tomosyns are widely thought to attenuate membrane fusion by competing with synaptobrevin-2/VAMP2 for SNARE-complex assembly. Here, we present evidence against this scenario. In a novel mouse model, tomosyn-1/2 deficiency lowered the fusion b
Externí odkaz:
https://doaj.org/article/9e5ac04838014cfc9c47148fbd0d6295
Autor:
Aygul Subkhangulova, Miguel A Gonzalez-Lozano, Alexander JA Groffen, Jan RT van Weering, August B Smit, Ruud F Toonen, Matthijs Verhage
Publikováno v:
eLife, Vol 12 (2023)
Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the brain, tomosyn inhibits the fusion of synaptic vesicles (SVs), whereas its role in the fusion o
Externí odkaz:
https://doaj.org/article/5b14d100d8134e01bd5d91d6962c2b54
Autor:
Aygul Subkhangulova, Miguel A. Gonzalez-Lozano, Alexander J. A. Groffen, Jan R. T. van Weering, August B. Smit, Ruud F. Toonen, Matthijs Verhage
Tomosyn is a large, non-canonical SNARE protein proposed to act as a competitive inhibitor of SNARE complex formation in vesicle exocytosis. In the brain, tomosyn inhibits fusion of synaptic vesicles (SVs), whereas its role in the fusion of neuropept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05abb6bf6d0dd1a5a2687f58508195b0
https://doi.org/10.1101/2022.12.18.520925
https://doi.org/10.1101/2022.12.18.520925
Autor:
David E. Taylor, Perry W.E. Spratt, Ling Bai, Aygul Subkhangulova, Yiming Chen, Seher Kosar, Rachel A Essner, Heeun Jang, Jennifer L. Garrison, Saul Kato, Zachary A. Knight, Evan H. Feinberg, David E. Leib, Kevin J. Bender, Mili Patel, Yen-Chu Lin, Tzu-Wei Kuo
Publikováno v:
Neuron. 107:454-469.e6
Neuroscience relies on techniques for imaging the structure and dynamics of neural circuits, but the cell bodies of individual neurons are often obscured by overlapping fluorescence from axons and dendrites in surrounding neuropil. Here, we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c1110c0a3f60ff9e446cc9965a069d
https://doi.org/10.1016/j.neuron.2020.05.005
https://doi.org/10.1016/j.neuron.2020.05.005
Autor:
Aygul, Subkhangulova, Anna R, Malik, Guido, Hermey, Oliver, Popp, Gunnar, Dittmar, Thomas, Rathjen, Matthew N, Poy, Alexander, Stumpf, Prateep Sanker, Beed, Dietmar, Schmitz, Tilman, Breiderhoff, Thomas E, Willnow
Publikováno v:
EMBO Reports
SORCS1 and SORCS3 are two related sorting receptors expressed in neurons of the arcuate nucleus of the hypothalamus. Using mouse models with individual or dual receptor deficiencies, we document a previously unknown function of these receptors in cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c3af65bcbe0883e5bb446532d920601
https://pubmed.ncbi.nlm.nih.gov/29440124
https://pubmed.ncbi.nlm.nih.gov/29440124
Publikováno v:
Cellular and Molecular Life Sciences
Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0536ff760378642b1d173f9334b7fb47