Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ayesa Syenina"'
Autor:
Jenny G. Low, Ruklanthi de Alwis, Shiwei Chen, Shirin Kalimuddin, Yan Shan Leong, Tania Ken Lin Mah, Natalene Yuen, Hwee Cheng Tan, Summer L. Zhang, Jean X. Y. Sim, Yvonne F. Z. Chan, Ayesa Syenina, Jia Xin Yee, Eugenia Z. Ong, Rose Sekulovich, Brian B. Sullivan, Kelly Lindert, Sean M. Sullivan, Pad Chivukula, Steven G. Hughes, Eng Eong Ooi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic. Phase
Externí odkaz:
https://doaj.org/article/8f3f3b68e6d74f248a8f293e7fa6c66a
Autor:
Eugenia Z. Ong, Jia Xin Yee, Justin S. G. Ooi, Ayesa Syenina, Ruklanthi de Alwis, Shiwei Chen, Jean X. Y. Sim, Shirin Kalimuddin, Yan Shan Leong, Yvonne F. Z. Chan, Rose Sekulovich, Brian M. Sullivan, Kelly Lindert, Sean B. Sullivan, Pad Chivukula, Steven G. Hughes, Jenny G. Low, Eng Eong Ooi, Kuan Rong Chan
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA vaccine is the self-amplifying mRNA (sa-mRNA) vaccine, which encodes an alphavirus rep
Externí odkaz:
https://doaj.org/article/f164a1f335254aad9b2305f3200a7da5
Autor:
Ayesa Syenina, Esther S. Gan, Justin Z. N. Toh, Ruklanthi de Alwis, Lowell Z. Lin, Christine Y. L. Tham, Jia Xin Yee, Yan Shan Leong, Huizhen Sam, Charlene Cheong, Yii Ean Teh, Ian L. E. Wee, Dorothy H. L. Ng, Kuan Rong Chan, Jean X. Y. Sim, Shirin Kalimuddin, Eugenia Z. Ong, Jenny G. Low, Eng Eong Ooi
Publikováno v:
PLoS Biology, Vol 20, Iss 5 (2022)
Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines currently in use, the mRNA vaccines have shown remarkable effectiveness. However
Externí odkaz:
https://doaj.org/article/ecfcaa6f536c4157ba77ecce6b10848c
Autor:
Ayesa Syenina, Wilfried A. A. Saron, Cyril J. Jagaraj, Siham Bibi, Michel Arock, Duane J. Gubler, Abhay P. S. Rathore, Soman N. Abraham, Ashley L. St. John
Publikováno v:
Viruses, Vol 12, Iss 12, p 1379 (2020)
Dengue virus (DENV), an arbovirus, strongly activates mast cells (MCs), which are key immune cells for pathogen immune surveillance. In animal models, MCs promote clearance of local peripheral DENV infections but, conversely, also promote pathologica
Externí odkaz:
https://doaj.org/article/ccb70b920eb84df3ae88bb9cb6d32e6b
Publikováno v:
eLife, Vol 4 (2015)
Dengue virus (DENV) is the most significant human arboviral pathogen and causes ∼400 million infections in humans each year. In previous work, we observed that mast cells (MC) mediate vascular leakage during DENV infection in mice and that levels o
Externí odkaz:
https://doaj.org/article/393b72b615524f4986b07ba8b813c930
Autor:
Eng Eong Ooi, Eugenia Ong, Jia Xin Yee, Justin Ooi, Ayesa Syenina, Ruklanthi de Alwis, Shiwei Chen, Jean Sim, Shirin Kalimuddin, Yan Shan Leong, Yvonne Chan, Rose Sekulovich, Brian Sullivan, Kelly Lindert, Sean Sullivan, Pad Chivukula, Steve Hughes, Jenny Low, Kuan Rong Chan
Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. This vaccine platform has been extended to encode an alphavirus replicase that self-amplifies the full length mRNA and SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::742101b404e01debc7c417a842e9d2fd
https://doi.org/10.21203/rs.3.rs-1629079/v1
https://doi.org/10.21203/rs.3.rs-1629079/v1
Autor:
Yvonne Fu Zi Chan, Eugenia Z. Ong, Yan Shan Leong, Kelly Lindert, Brian B Sullivan, Eng Eong Ooi, Ruklanthi de Alwis, Rose Sekulovich, Jia Xin Yee, Jenny G. Low, Shiwei Chen, Jean Siim, Summer L. Zhang, Shirin Kalimuddin, Pad Chivukula, Ayesa Syenina, Tania Mah, Hwee Cheng Tan, Sean M. Sullivan, Steven G Hughes, Natalene Yuen
BackgroundThe pandemic of coronavirus disease-19 (Covid-19) continues to afflict the lives and livelihoods of many as global demand for vaccine supply remains unmet.MethodsPhase 1 of this trial (N=42) assessed the safety, tolerability and immunogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00fc3b0dcf4a231ed451fc5c33ea2672
https://doi.org/10.1101/2021.07.01.21259831
https://doi.org/10.1101/2021.07.01.21259831
Autor:
Eng Eong Ooi, Hwee Cheng Tan, Ravisankar Rajarethinam, Satoru Watanabe, Benson Ng, Gavin J. D. Smith, Summer L. Zhang, Esther S. Gan, Ayesa Syenina, Martin Linster
Publikováno v:
Antiviral Research
The global spread of SARS-CoV-2 has made millions ill with COVID-19 and even more from the economic fallout of this pandemic. Our quest to test new therapeutics and vaccines require small animal models that replicate disease phenotypes seen in COVID-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f770c269e99fe12e3d7bdc7c7e024bd5
https://pubmed.ncbi.nlm.nih.gov/34246735
https://pubmed.ncbi.nlm.nih.gov/34246735
Autor:
Martin Qui, Ruklanthi de Alwis, Christine Y.L. Tham, Eng Eong Ooi, Nina Le Bert, Eugenia Z. Ong, Anthony T. Tan, Antonio Bertoletti, Joey M.E. Lim, Summer L. Zhang, Jia Xin Yee, Ayesa Syenina, Yan Shan Leong, Shirin Kalimuddin, Jean X.Y. Sim, Hwee Cheng Tan, Jenny G. Low
Publikováno v:
Med (New York, N.y.)
Background RNA vaccines against coronavirus disease 2019 (COVID-19) have demonstrated ∼95% efficacy in phase III clinical trials. Although complete vaccination consisted of 2 doses, the onset of protection for both licensed RNA vaccines was observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeb411095ad9f4b74ace4e49e0f6114
http://europepmc.org/articles/PMC8030737
http://europepmc.org/articles/PMC8030737
Autor:
Ayesa Syenina, Hwee Cheng Tan, Antonio Bertoletti, Martin Qui, Yan Shan Leong, Jenny G. Low, Anthony T. Tan, Eugenia Z. Ong, Ruklanthi de Alwis, Christine Y.L. Tham, Eng Eong Ooi, Shirin Kalimuddin, Joey M.E. Lim, Jia Xin Yee, Nina Le Bert, Summer L. Zhang, Jean X.Y. Sim
Publikováno v:
SSRN Electronic Journal.
RNA vaccines against Covid-19 have demonstrated ~95% efficacy in Phase III clinical trials. Although complete vaccination consisted of two-doses, the onset of protection for both licensed RNA vaccines was observed as early as 12 days after a single d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::946fe3b99f8191e7d2d199aea7cbd0da
https://doi.org/10.2139/ssrn.3796533
https://doi.org/10.2139/ssrn.3796533