Výsledky vyhledávání - "Ayelet Shabtay"

Akademický článek

Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit

Autor: Elad Jacoby, Moriya Ben Yakir-Blumkin, Shiri Blumenfeld-Kan, Yehuda Brody, Amilia Meir, Naomi Melamed-Book, Tina Napso, Gat Pozner, Esraa Saadi, Ayelet Shabtay-Orbach, Natalie Yivgi-Ohana, Noa Sher, Amos Toren

Publikováno v: npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-12 (2021)

Abstract Mitochondria are cellular organelles critical for numerous cellular processes and harboring their own circular mitochondrial DNA (mtDNA). Most mtDNA associated disorders (either deletions, mutations, or depletion) lead to multisystemic disea

Externí odkaz: https://doaj.org/article/ea28dd8efa07497c88f0f158a175ba5b

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Akademický článek

Injectable Drug Delivery System Based on In Situ Self‐Assembly of Liquid Star Polyethylene Glycol–Poly(lactic‐co‐glycolic acid)

Autor: Bat-hen Eylon, Alona Shagan, Ayelet Shabtay-Orbach, Adi Gross, Boaz Mizrahi

Publikováno v: Advanced NanoBiomed Research, Vol 1, Iss 3, Pp n/a-n/a (2021)

Particulate systems are widely used in biomedical applications, yet current systems are limited by their stability, complicated production processes, and the use of toxic excipients and cosolvents. Here, a new concept for an injectable nanocarrier sy

Externí odkaz: https://doaj.org/article/a18a1761d04f47d38e43a12efa0003bf

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Akademický článek

Characterization of the melanoma brain metastatic niche in mice and humans

Autor: Moran Amit, Leonor Laider‐Trejo, Vardit Shalom, Ayelet Shabtay‐Orbach, Yakov Krelin, Ziv Gil

Publikováno v: Cancer Medicine, Vol 2, Iss 2, Pp 155-163 (2013)

Abstract Brain metastases occur in 15% of patients with melanoma and are associated with a dismal prognosis. Here, we investigate the architectural phenotype and stromal reaction of melanoma brain metastasis in mice and humans. A syngeneic, green flu

Externí odkaz: https://doaj.org/article/5f163522ece348bc81eadeaf30fba591

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Supplementary Figure 4 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor

Autor: Ziv Gil, Moran Amit, Richard J. Wong, Yuman Fong, Yakov Krelin, Noam Weizman, Leonor Trejo-Leider, Joseph Vital, Ayelet Shabtay, Olga Shomron, Oren Cavel

PDF file - 174K, Expression of the GDNF receptors GFRa1 and RET in specimens excised from patients with pancreatic ductal adenocarcinoma.(a) Low magnification (X20) immunofluorescence staining with anti-RET ab (green, Alexa 485), (b) anti-GFRa1 ab (r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708fa0ae43103ba25548ba73830e813f
https://doi.org/10.1158/0008-5472.22395536.v1

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Supplementary Figure 1 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor

Autor: Ziv Gil, Moran Amit, Richard J. Wong, Yuman Fong, Yakov Krelin, Noam Weizman, Leonor Trejo-Leider, Joseph Vital, Ayelet Shabtay, Olga Shomron, Oren Cavel

PDF file - 112K, The ability of EMPhis to invade in a matrigel matrix towards a colony of PDA cancer cells.(a) An illustration showing the calculation of the invasion distance. (b) A photograph of the assay showing that the invasion of EMPhis was mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010b07cfc1bbc580531a087d4061dd21
https://doi.org/10.1158/0008-5472.22395545.v1

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Supplementary Figure 3 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor

Autor: Ziv Gil, Moran Amit, Richard J. Wong, Yuman Fong, Yakov Krelin, Noam Weizman, Leonor Trejo-Leider, Joseph Vital, Ayelet Shabtay, Olga Shomron, Oren Cavel

PDF file - 178K, Scratch assays of MiaPaCa2 cells in the presence or absence of EMPhi-CM. (a) Representative pictures taken after 24 and 48 hours showing increased motility of cancer cells incubated with EMPhi-CM (lower row) relative to normal medium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062bb2d298bc3190615a86f6346d1ac3
https://doi.org/10.1158/0008-5472.22395539

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Supplementary Figure 5 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor

Autor: Ziv Gil, Moran Amit, Richard J. Wong, Yuman Fong, Yakov Krelin, Noam Weizman, Leonor Trejo-Leider, Joseph Vital, Ayelet Shabtay, Olga Shomron, Oren Cavel

PDF file - 25K, The effect of PYP1 on the PDA cells proliferation. As revealed by XTT assay, PYP1 (2mum) had no effect on cancer cell proliferation induced by the EMPhi conditioned media.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fddda1307359c61c63438e2c20d5063
https://doi.org/10.1158/0008-5472.22395533.v1

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Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit

Autor: Ayelet Shabtay-Orbach, Elad Jacoby, Amilia Meir, Amos Toren, Noa Sher, Esraa Saadi, Natalie Yivgi-Ohana, Gat Pozner, Moriya Ben Yakir-Blumkin, Shiri Blumenfeld-Kan, Tina Napso, Naomi Melamed-Book, Yehuda Brody

Publikováno v: npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-12 (2021)

Mitochondria are cellular organelles critical for numerous cellular processes and harboring their own circular mitochondrial DNA (mtDNA). Most mtDNA associated disorders (either deletions, mutations, or depletion) lead to multisystemic disease, often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a022d4baa29d74a4fe1a0c4eca4eb8
https://doaj.org/article/ea28dd8efa07497c88f0f158a175ba5b

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A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy

Autor: Tammi Arbel Rubinstein, Inbal Reuveni, Arkadi Hesin, Anat Klein-Goldberg, Hannes Olauson, Tobias E. Larsson, Carmela R. Abraham, Ella Zeldich, Assumpció Bosch, Miguel Chillón, Kenneth Samuel Hollander, Ayelet Shabtay-Orbach, Gilad W. Vainer, Ido Wolf, Tami Rubinek

Publikováno v: Cancers, Vol 13, Iss 6297, p 6297 (2021)
Cancers; Volume 13; Issue 24; Pages: 6297
Cancers
Scientia

Simple Summary We aimed to study the role of the anti-aging protein klotho and its secreted isoform, sKL, in pancreatic cancer. Three in vivo models, including a novel genetic mouse model and bioinformatics analyses, indicated klotho as a tumor suppr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7840f90fb214a509b478b4a541aae8
https://www.mdpi.com/2072-6694/13/24/6297

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A new volatile antimicrobial agent-releasing patch for preserving fresh foods

Autor: Boaz Mizrahi, Guy Tenenbaum, Boris Rozenblit, Ayelet Shabtay-Orbach, Enav Corem Salkmon, Alona Shagan

Publikováno v: Food Packaging and Shelf Life. 18:184-190

Active packaging that releases antibacterial volatile oils has been one of the most promising approaches to protecting fresh food and increasing its shelf life. Existing strategies, however, are limited by the need to adjust packaging material to sui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43bc5d508a50d02240be6c50b0df75cf
https://doi.org/10.1016/j.fpsl.2018.11.003

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