Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ayelet M, Samuni"'
Autor:
Ayelet M. Samuni, Usha Kasid, Eric Y. Chuang, Simeng Suy, William DeGraff, Murali C. Krishna, Angelo Russo, James B. Mitchell
Publikováno v:
Cancer Research. 65:579-586
Despite significant evidence of a role of hypoxia in cellular resistance to ionizing radiation–induced toxicity, the underlying molecular mechanisms remain unclear. This study focused on the influence of hypoxia on radiation-induced signals in TK6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d9af44ded615d554ab6ca88a487ffda
https://doi.org/10.1158/0008-5472.579.65.2
https://doi.org/10.1158/0008-5472.579.65.2
Publikováno v:
Cancer. 103:1302-1313
BACKGROUND In previous studies, nitroxide tempo (2, 2, 6, 6-tetramethyl-piperidine-1-oxyl), a small molecule, induced cell death in cancer cells. The current study examined the antineoplastic properties of tempo in the human hormone-dependent/hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5a06796fc47b74d7664067fee1565a
https://doi.org/10.1002/cncr.20898
https://doi.org/10.1002/cncr.20898
Autor:
Janet Gamson, Murali C. Krishna, Ayelet M. Samuni, Angelo Russo, Ken Ichi Yamada, James B. Mitchell, Yuval Samuni
Publikováno v:
Antioxidants & Redox Signaling. 6:587-595
Nitroxides have been shown to be effective antioxidants, radiation protectors, and redox-active probes for functional electron paramagnetic resonance (EPR) imaging. More recently, the nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-N-oxyl (Tempol)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f9a26c9e9a4d50815e7347bc320eec
https://doi.org/10.1089/152308604773934341
https://doi.org/10.1089/152308604773934341
Autor:
Anastasia L. Sowers, Makiko Fujii, Michael Reiss, Delphine Javelaud, Alain Mauviel, Ayelet M. Samuni, Sandhya Xavier, James B. Mitchell, Angelo Russo, Kathy Flanders, Shai Yarkoni, Anita B. Roberts, Ester Piek, Angelina Felici
Publikováno v:
Journal of Biological Chemistry. 279:15167-15176
Radiation-induced fibrosis is an untoward effect of high dose therapeutic and inadvertent exposure to ionizing radiation. Transforming growth factor-beta (TGF-beta) has been proposed to be critical in tissue repair mechanisms resulting from radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a44d53c8e9fb38f00fd587d1b121069f
https://doi.org/10.1074/jbc.m309798200
https://doi.org/10.1074/jbc.m309798200
Autor:
Angelo Russo, William DeGraff, Murali C. Krishna, Ayelet M. Samuni, William E. Stein, Eric Y. Chuang, James B. Mitchell
Publikováno v:
Proceedings of the National Academy of Sciences. 100:5390-5395
Modulation of the cytotoxicity and mutagenicity of 4-hydroxyestradiol (4-OHE 2 ), an oxidative metabolite of estrogen, by antioxidants was assessed in human MCF7 cells and TK-6 lymphoblast cells. The cytotoxicity of the catecholic estrogens was poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b99f3be1a16ac09c6b9c4f6017e64b
https://doi.org/10.1073/pnas.0930078100
https://doi.org/10.1073/pnas.0930078100
Autor:
Ayelet M. Samuni, Yechezkel Barenholz
Publikováno v:
Free Radical Biology and Medicine. 34:177-185
A relatively new strategy in preventing oxidative damage employs cyclic nitroxides. These stable radicals have been widely used as biophysical probes, spin labels, and are currently tested as contrast agents for nuclear magnetic resonance imaging. Ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37f353be4e9fdf5975ec1579a571de2
https://doi.org/10.1016/s0891-5849(02)01238-8
https://doi.org/10.1016/s0891-5849(02)01238-8
Autor:
Krish Chandrasekaran, Sushil Chandani, Dorairajan Balasubramanian, Ayelet M. Samuni, Geetha Thiagarajan, Sithamraju Harinarayana Rao
Publikováno v:
Experimental Eye Research. 75:421-430
We have investigated the biochemical and cell biological basis of the reported beneficiary effects of the leaf extracts of the plant Ginkgo biloba, which has been used as a possible ophthalmic drug. The antioxidant, antimicrobial, anti-apoptotic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0236a03b8748ce900c13a4f5949e61e0
https://doi.org/10.1006/exer.2002.2035
https://doi.org/10.1006/exer.2002.2035
Autor:
Roy P. Planalp, William DeGraff, Murali C. Krishna, James B. Mitchell, Martin W. Brechbiel, Angelo Russo, Ayelet M. Samuni
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1571:211-218
Tachpyr (N,NVNW-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane), a novel metal chelator, was previously shown to deplete intracellular iron and exert a cytotoxic effect on cultured bladder cancer cells. Tachpyr binds Fe(II) and readily reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27915708a10a98ab4b8a394e439effb1
https://doi.org/10.1016/s0304-4165(02)00218-0
https://doi.org/10.1016/s0304-4165(02)00218-0
Autor:
James B. Mitchell, Ayelet M. Samuni, Harvey I. Pass, W. Matthews, Angelo Russo, Helen W. Pogrebniak
Publikováno v:
Journal of Surgical Research. 50:469-474
Tumor necrosis factor (TNF) facilitates superoxide production, and spin traps may detoxify superoxide by acting as superoxide dismutase mimics. We investigated the ability of a stable nitroxide spin trap, TEMPOL, to protect TNF-sensitive cells from e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041fe692a77281603949064c4b98f98f
https://doi.org/10.1016/0022-4804(91)90026-i
https://doi.org/10.1016/0022-4804(91)90026-i
Autor:
Ayelet M, Samuni, Usha, Kasid, Eric Y, Chuang, Simeng, Suy, William, Degraff, Murali C, Krishna, Angelo, Russo, James B, Mitchell
Publikováno v:
Cancer research. 65(2)
Despite significant evidence of a role of hypoxia in cellular resistance to ionizing radiation-induced toxicity, the underlying molecular mechanisms remain unclear. This study focused on the influence of hypoxia on radiation-induced signals in TK6 hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc76639b14bbd3fcccf3e02fda2cb5c6
https://pubmed.ncbi.nlm.nih.gov/15695402
https://pubmed.ncbi.nlm.nih.gov/15695402