Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ayeda Ayed"'
Autor:
Harry W. Duckworth, Ayeda Ayed, Lynda J. Donald, Brigitte Bruneau, Yin Gao, Nham T. Nguyen, Gary D. Brayer, Robert Maurus
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834:2546-2553
The citrate synthase (CS) of Escherichia coli is an allosteric hexameric enzyme specifically inhibited by NADH. The crystal structure of wild type (WT) E. coli CS, determined by us previously, has no substrates bound, and part of the active site is i
Autor:
Lilia Kaustov, Cheryl H. Arrowsmith, Gwan-Su Yi, Elena Bochkareva, Alexey Bochkarev, Ayeda Ayed
Publikováno v:
Cell Cycle. 5:489-494
The recent structure of human replication protein A (RPA) bound to residues 38-58 of tumor suppressor p53 exemplifies several important features of protein-protein interactions involved in transcription and DNA repair. First, the N-terminal transcrip
Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
Autor:
Ayeda Ayed, Cheryl H. Arrowsmith, Jack C.C. Liao, Lilia Kaustov, Antonio Pineda-Lucena, Elena Bochkareva, Andrei L. Okorokov, Gwan-Su Yi, Alexey Bochkarev, Jo Milner, Ying Lu
Publikováno v:
Proceedings of the National Academy of Sciences. 102:15412-15417
One of many protein–protein interactions modulated upon DNA damage is that of the single-stranded DNA-binding protein, replication protein A (RPA), with the p53 tumor suppressor. Here we report the crystal structure of RPA residues 1–120 (RPA70N)
Publikováno v:
Nature Structural Biology. 8:756-760
p53 is a nuclear phosphoprotein that regulates cellular fate after genotoxic stress through its role as a transcriptional regulator of genes involved in cell cycle control and apoptosis. The C-terminal region of p53 is known to negatively regulate se
Autor:
Richard C. Austin, Jeffrey V. Wong, Anthony Brade, Henry J. Klamut, Cheryl H. Arrowsmith, Pei-Xiang Li, Ayeda Ayed, Duc Ngo
Publikováno v:
Journal of Biological Chemistry. 275:20127-20135
The p53 tumor suppressor gene and members of the transforming growth factor-beta (TGF-beta) superfamily play central roles in signaling cell cycle arrest and apoptosis (programmed cell death) in normal development and differentiation, as well as in c
Publikováno v:
Journal of Biomolecular NMR. 18:173-176
The p53 tumor suppressor is a transcription factor that plays a crucial role in the activation of genes in response to DNA damage. As a first step towards detailed structural studies of the molecule aimed at understanding its regulation, we have used
Publikováno v:
Rapid Communications in Mass Spectrometry. 12:339-344
A mass spectrometer coupling electrospray ionization with time-of-flight mass spectrometry (ESI-TOFMS) has been used to investigate the oligomeric species of Escherichia coli citrate synthase, and to determine the effect of nicotinamide adenine dinuc
Autor:
Ayeda Ayed, Theodore Hupp
Publikováno v:
Molecular Biology Intelligence Unit ISBN: 9781441982308
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad8bce2ae413b81c247fb397a9e45dd2
https://doi.org/10.1007/978-1-4419-8231-5
https://doi.org/10.1007/978-1-4419-8231-5
Autor:
Blair R. Szymczyna, Jack C.C. Liao, Cheryl H. Arrowsmith, Rob C. Laister, Ying Lu, Avi Chakrabartty, Ayeda Ayed, Wen Ying Mark
Publikováno v:
Journal of molecular biology. 345(2)
The BRCA1 tumor suppressor gene encodes an 1863 amino acid gene product that is implicated in many cellular pathways including transcription, cell-cycle checkpoint control, apoptosis and DNA repair. Much attention has been focused on the structural a