Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aye T. Chen"'
Autor:
Shelly Sorrells, Seth Carbonneau, Erik Harrington, Aye T Chen, Bridgid Hast, Brett Milash, Ujwal Pyati, Michael B Major, Yi Zhou, Leonard I Zon, Rodney A Stewart, A Thomas Look, Cicely Jette
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002922 (2012)
DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful eli
Externí odkaz:
https://doaj.org/article/1b9c52b106054d52a603a166423650ef
Autor:
Vandana A Gupta, Genri Kawahara, Jennifer A Myers, Aye T Chen, Thomas E Hall, M Chiara Manzini, Peter D Currie, Yi Zhou, Leonard I Zon, Louis M Kunkel, Alan H Beggs
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43794 (2012)
Congenital muscular dystrophy (CMD) is a clinically and genetically heterogeneous group of inherited muscle disorders. In patients, muscle weakness is usually present at or shortly after birth and is progressive in nature. Merosin deficient congenita
Externí odkaz:
https://doaj.org/article/40ee2aaa24de44049e1cbd0ed11f8c8b
Autor:
Heidi K. Jessup, Ruth Salmon, Jim Qin, Evan Paul Thomas, Melissa Works, Oleksandr Baturevych, Aye T. Chen, Michael Ports, Yue Jiang, Neha Soni
Publikováno v:
Cancer Research. 79:2320-2320
Lisocabtagene maraleucel (liso-cel) is an investigational drug product composed of autologous CD8+ and CD4+ T cells expressing a CD19-specific chimeric antigen receptor (CAR), being evaluated in clinical trials for treatment of B cell malignancies. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::200dd74556fdfe07d37445d5e56e5eab
https://doi.org/10.1158/1538-7445.am2019-2320
https://doi.org/10.1158/1538-7445.am2019-2320
Autor:
Stacey R. Gundry, Vandana Gupta, Alan H. Beggs, Aye T. Chen, Louis M. Kunkel, Yi Zhou, Wayne I. Lencer, Leonard I. Zon, Genri Kawahara
Publikováno v:
Human Molecular Genetics. 20:1712-1725
In a forward genetic approach to identify novel genes for congenital muscle diseases, a zebrafish mutant, designated patchytail, was identified that exhibits degenerating muscle fibers with impaired motility behavior. Genetic mapping identified a gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242c5415716cfd0d0627846345f9aedf
https://doi.org/10.1093/hmg/ddr047
https://doi.org/10.1093/hmg/ddr047
Autor:
Leonard I. Zon, Louis M. Kunkel, Chiara Manzini, Alan H. Beggs, Jennifer Myers, Vandana Gupta, Genri Kawahara, Thomas E. Hall, Peter D. Currie, Yi Zhou, Aye T. Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43794 (2012)
PLoS ONE
PLoS ONE
Congenital muscular dystrophy (CMD) is a clinically and genetically heterogeneous group of inherited muscle disorders. In patients, muscle weakness is usually present at or shortly after birth and is progressive in nature. Merosin deficient congenita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1cb0342b82b06b5d50f304bb7a5c84
http://europepmc.org/articles/PMC3428294?pdf=render
http://europepmc.org/articles/PMC3428294?pdf=render
Autor:
Alexandra C. H. Smith, Jill L. O. de Jong, Aye T. Chen, Leonard I. Zon, Yi Zhou, Emily K. Pugach, Elizabeth A. Mayhall, Henry A. Feldman, Caroline E. Burns
Evaluating hematopoietic stem cell (HSC) function in vivo requires a long-term transplantation assay. Although zebrafish are a powerful model for discovering the genetics of hematopoiesis, hematopoietic transplantation approaches have been underdevel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2b2e2145572404eab724fa7b966e67
https://europepmc.org/articles/PMC3087475/
https://europepmc.org/articles/PMC3087475/
Autor:
Yi Zhou, Niccolo Bolli, John P. Kanki, Jeong-Soo Lee, Jennifer Rhodes, Elspeth Payne, Leonard I. Zon, Adam Johnston, Feng Guo, Aye T. Chen, Evisa Gjini, A. Thomas Look, Rodney A. Stewart
Publikováno v:
Blood. 117(15)
A comprehensive understanding of the genes and pathways regulating hematopoiesis is needed to identify genes causally related to bone marrow failure syndromes, myelodysplastic syndromes, and hematopoietic neoplasms. To identify novel genes involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a561e1083cb57a0671cf8bd8422153
https://pubmed.ncbi.nlm.nih.gov/21330472
https://pubmed.ncbi.nlm.nih.gov/21330472
Autor:
Leonard I. Zon, Aye T. Chen
Publikováno v:
Journal of cellular biochemistry. 108(1)
Within the past two decades, the zebrafish (Danio rerio) has become an excellent model to study the development of hematopoietic stem cells (HSCs). All vertebrates including zebrafish have primitive and definitive waves of hematopoiesis, but self-ren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ef4558559281bf558b349c8ef2c6ce
https://pubmed.ncbi.nlm.nih.gov/19565566
https://pubmed.ncbi.nlm.nih.gov/19565566
Autor:
Erik B. Harrington, Michael B. Major, Shelly Sorrells, Cicely A. Jette, Rodney A. Stewart, Leonard I. Zon, Ujwal J. Pyati, Seth Carbonneau, Yi Zhou, Aye T. Chen, A. Thomas Look, Brett Milash, Bridgid E. Hast
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002922 (2012)
PLoS Genetics
PLoS Genetics
DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful eli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8885c18ccc35662baf37104dd6960ba2
https://doi.org/10.1371/journal.pgen.1002922
https://doi.org/10.1371/journal.pgen.1002922
Autor:
Jeong-Soo Lee, Feng Guo, Niccolo Bolli, Aye T. Chen, A. Thomas Look, Yi Zhou, Elspeth Payne, Jennifer Rhodes, John P. Kanki, Leonard I. Zon, Adam Johnston
Publikováno v:
Blood. 116:1606-1606
Abstract 1606 Hematopoiesis is a tightly regulated process requiring the differential activation of specific genetic programs. Inactivating mutations of genes involved in normal hematopoiesis have been implicated in bone marrow failure syndromes, mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c758838f15659206ca9e09429e64a74
https://doi.org/10.1182/blood.v116.21.1606.1606
https://doi.org/10.1182/blood.v116.21.1606.1606