Placental polyamines regulate acetyl-coA and histone acetylation in a sex-specific manner

Autor: Francesca Gaccioli, Albert Koulman, Barbagallo R, Smith Gcs, Benjamin Jenkins, Aye Ilmh, Andrew J. Murray, D.S. Charnock-Jones, Sungsam Gong, Avellino G

Fetal sex differences play an important role in the pathophysiology of several placenta-related pregnancy complications. We previously reported that the maternal circulating level of a polyamine metabolite was altered in a fetal sex-specific manner,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b1fa5fab3bbd2b6c695c1d512944af1
https://doi.org/10.1101/2021.06.09.447192

Human placental cells are resistant to SARS-CoV-2 infection and replication.

Autor: Yoshida N; Department of Pathology, University of Cambridge, Cambridge, England, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, England, UK., Thomas JR; Department of Pathology, University of Cambridge, Cambridge, England, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, England, UK., Appios A; Department of Pathology, University of Cambridge, Cambridge, England, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, England, UK., Brember MP; Department of Pathology, University of Cambridge, Cambridge, England, UK., Aye ILMH; Centre for Trophoblast Research, University of Cambridge, Cambridge, England, UK.; Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, England, UK., Edgar JR; Department of Pathology, University of Cambridge, Cambridge, England, UK., Firth AE; Department of Pathology, University of Cambridge, Cambridge, England, UK., Chung BYW; Department of Pathology, University of Cambridge, Cambridge, England, UK., McGovern N; Department of Pathology, University of Cambridge, Cambridge, England, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, England, UK., Stewart H; Department of Pathology, University of Cambridge, Cambridge, England, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2024 Nov 22; Vol. 9, pp. 209. Date of Electronic Publication: 2024 Nov 22 (Print Publication: 2024).

Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function.

Autor: Avellino G; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.; Department of Physiology, Development and Neuroscience, Centre for Trophoblast Research (CTR), University of Cambridge, Cambridge, United Kingdom., Deshmukh R; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, United Kingdom., Rogers SN; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom., Charnock-Jones DS; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.; Department of Physiology, Development and Neuroscience, Centre for Trophoblast Research (CTR), University of Cambridge, Cambridge, United Kingdom., Smith GCS; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.; Department of Physiology, Development and Neuroscience, Centre for Trophoblast Research (CTR), University of Cambridge, Cambridge, United Kingdom., Tardito S; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, United Kingdom.; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Aye ILMH; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.; Department of Physiology, Development and Neuroscience, Centre for Trophoblast Research (CTR), University of Cambridge, Cambridge, United Kingdom.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2023 Apr 01; Vol. 324 (4), pp. C878-C885. Date of Electronic Publication: 2023 Mar 06.

Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation.

Autor: Aye ILMH; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK. ia319@medschl.cam.ac.uk.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. ia319@medschl.cam.ac.uk., Gong S; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Avellino G; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Barbagallo R; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Gaccioli F; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Jenkins BJ; NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge, UK., Koulman A; NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge, UK., Murray AJ; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Stephen Charnock-Jones D; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Smith GCS; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Publikováno v: Communications biology [Commun Biol] 2022 Jun 15; Vol. 5 (1), pp. 586. Date of Electronic Publication: 2022 Jun 15.

Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity.

Autor: Aye ILMH; Department of Obstetrics & Gynaecology, and Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Rosario FJ; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Kramer A; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Kristiansen O; Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Michelsen TM; Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Powell TL; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Jansson T; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Jan 01; Vol. 107 (1), pp. 53-66.