Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Aye Aye Thike"'
Autor:
Hannah Si Hui Lau, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Yirong Sim, Jelmar Quist, Aye Aye Thike, Puay Hoon Tan, Shazib Pervaiz, Anita Grigoriadis, Kanaga Sabapathy
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Despite our understanding of the genetic basis of intra-tumoral heterogeneity, the role of stromal heterogeneity arising from an altered tumor microenvironment in affecting tumorigenesis is poorly understood. In particular, extensive study o
Externí odkaz:
https://doaj.org/article/482f96ed3bbe408b8d0cdb71f2bc3858
Autor:
Chong Hui Clara Ong, Dong Yeul Lee, Bernett Lee, Huihua Li, Jeffrey Chun Tatt Lim, Johnathan Xiande Lim, Joe Poh Sheng Yeong, Hiu Yeung Lau, Aye Aye Thike, Puay Hoon Tan, Jabed Iqbal
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background The effect of extracellular microenvironment (hypoxia and pH) has been regarded as a key hallmark in cancer progression. The study aims to investigate the effects of carbonic anhydrase IX (CAIX), a key hypoxia-inducible marker, in
Externí odkaz:
https://doaj.org/article/ee51c9920f174f54b364a33da90920b8
Autor:
Dave Yong Xiang Ng, Zhimei Li, Elizabeth Lee, Jessica Sook Ting Kok, Jing Yi Lee, Joanna Koh, Cedric Chuan-Young Ng, Abner Herbert Lim, Wei Liu, Sheng Rong Ng, Kah Suan Lim, Xi Xiao Huang, Jing Han Hong, Peiyong Guan, Yirong Sim, Aye Aye Thike, Nur Diyana Md Nasir, Shang Li, Puay Hoon Tan, Bin Tean Teh, Jason Yongsheng Chan
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT
Externí odkaz:
https://doaj.org/article/bd28bd0bf05246bbaccb1e4e99e36462
Autor:
Ser Yue Loo, Nicholas L. Syn, Angele Pei-Fern Koh, Janet Cheng-Fei Teng, Amudha Deivasigamani, Tuan Zea Tan, Aye Aye Thike, Shireen Vali, Shweta Kapoor, Xiaoyuan Wang, Jiong Wei Wang, Puay Hoon Tan, George W. Yip, Gautam Sethi, Ruby Yun-Ju Huang, Kam Man Hui, Lingzhi Wang, Boon Cher Goh, Alan Prem Kumar
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Clinical trials repurposing peroxisome proliferator-activated receptor-gamma (PPARγ) agonists as anticancer agents have exhibited lackluster efficacy across a variety of tumor types. Here, we report that increased PPARG expression is associ
Externí odkaz:
https://doaj.org/article/82fb2ea92fce4d45b46ee3f019c45a37
Autor:
Cedric Chuan-Young Ng, Sandy Lim, Abner Herbert Lim, Nur Diyana Md Nasir, Jingxian Zhang, Vikneswari Rajasegaran, Jing Yi Lee, Jessica Sook Ting Kok, Aye Aye Thike, Johnathan Xiande Lim, Ruifen Weng, Sidney Yee, Yukti Choudhury, Jason Yongsheng Chan, Puay Hoon Tan, Min-Han Tan, Bin Tean Teh
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Introduction: A well-validated diagnostic assay with curated biomarkers complements clinicopathological factors to facilitate early diagnosis and ensure timely treatment delivery. This study focuses on an Asian-centric cancer diagnostic assay designe
Externí odkaz:
https://doaj.org/article/01db8eb942f6482085e4d3ecfd293907
Autor:
Soumya Ghose, Sanghee Cho, Fiona Ginty, Elizabeth McDonough, Cynthia Davis, Zhanpan Zhang, Jhimli Mitra, Adrian L. Harris, Aye Aye Thike, Puay Hoon Tan, Yesim Gökmen-Polar, Sunil S. Badve
Publikováno v:
Cancers, Vol 15, Iss 7, p 1922 (2023)
Standard clinicopathological parameters (age, growth pattern, tumor size, margin status, and grade) have been shown to have limited value in predicting recurrence in ductal carcinoma in situ (DCIS) patients. Early and accurate recurrence prediction w
Externí odkaz:
https://doaj.org/article/c4183dab9f604c55b311eb5f6ab0625f
Autor:
Laurent Gole, Joe Yeong, Jeffrey Chun Tatt Lim, Kok Haur Ong, Hao Han, Aye Aye Thike, Yong Cheng Poh, Sidney Yee, Jabed Iqbal, Wanjin Hong, Bernett Lee, Weimiao Yu, Puay Hoon Tan
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-13 (2020)
Abstract Background Stromal and collagen biology has a significant impact on tumorigenesis and metastasis. Collagen is a major structural extracellular matrix component in breast cancer, but its role in cancer progression is the subject of historical
Externí odkaz:
https://doaj.org/article/6c2e51defd8b4e8babd863727565f336
Autor:
Yirong Sim, Gwendolene Xin Pei Ng, Cedric Chuan Young Ng, Vikneswari Rajasegaran, Suet Far Wong, Wei Liu, Peiyong Guan, Sanjanaa Nagarajan, Wai Yee Ng, Aye Aye Thike, Jeffrey Chun Tatt Lim, Nur Diyana Binte Md Nasir, Veronique Kiak Mien Tan, Preetha Madhukumar, Wei Sean Yong, Chow Yin Wong, Benita Kiat Tee Tan, Kong Wee Ong, Bin Tean Teh, Puay Hoon Tan
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background Known collectively as breast fibroepithelial lesions (FELs), the common fibroadenomas (FAs) and the rarer phyllodes tumors (PTs) are a heterogenous group of biphasic neoplasms. Owing to limited tissue availability, inter-observer
Externí odkaz:
https://doaj.org/article/439bddb112b0407f82296f233009f413
Autor:
Sunil S. Badve, Sanghee Cho, Xiaoyu Lu, Sha Cao, Soumya Ghose, Aye Aye Thike, Puay Hoon Tan, Idris Tolgay Ocal, Daniele Generali, Fabrizio Zanconati, Adrian L. Harris, Fiona Ginty, Yesim Gökmen-Polar
Publikováno v:
Cancers, Vol 14, Iss 16, p 3916 (2022)
Tumor-infiltrating lymphocytes (TILs) are prognostic in invasive breast cancer. However, their prognostic significance in ductal carcinoma in situ (DCIS) has been controversial. To investigate the prognostic role of TILs in DCIS outcome, we used diff
Externí odkaz:
https://doaj.org/article/8a657860535842f4bad7ebfbd7a7ff3a
Autor:
Joe Yeong, Jeffrey Chun Tatt Lim, Bernett Lee, Huihua Li, Clara Chong Hui Ong, Aye Aye Thike, Wei Hseun Yeap, Yi Yang, Ansel Yi Herh Lim, Timothy Kwang Yong Tay, Jin Liu, Siew-Cheng Wong, Jinmiao Chen, Elaine Hsuen Lim, Jabed Iqbal, Rebecca Dent, Evan W. Newell, Puay Hoon Tan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract The role of programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) in triple negative breast cancer (TNBC) remains to be fully understood. In this study, we investigated the role of PD-1 as a prognostic marker for TNBC
Externí odkaz:
https://doaj.org/article/35978560b7ed430d90205d61ba30773f