Výsledky vyhledávání - "Aye Aye K Ma"

Akademický článek

Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease.

Autor: Mei Li, Douglas Yasumura, Aye Aye K Ma, Michael T Matthes, Haidong Yang, Gregory Nielson, Yong Huang, Francis C Szoka, Matthew M Lavail, Marc I Diamond

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56026 (2013)

Huntington disease (HD) is an inherited neurodegenerative disease that affects multiple brain regions. It is caused by an expanded polyglutamine tract in huntingtin (Htt). The development of therapies for HD and other neurodegenerative diseases has b

Externí odkaz: https://doaj.org/article/7e3484705d5c43ee9ae68c9aba56ed2f

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Akademický článek

Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice

Autor: Mei Li, Yong Huang, Aye Aye K. Ma, Emil Lin, Marc I. Diamond

Publikováno v: Neurobiology of Disease, Vol 36, Iss 3, Pp 413-420 (2009)

Huntington disease (HD) is a devastating, untreatable, dominantly inherited neurodegenerative disease. It is caused by an expanded CAG codon repeat that leads to an elongated polyglutamine tract in the N-terminus of the huntingtin (Htt) protein. Few

Externí odkaz: https://doaj.org/article/f5a2890f8ac9459d8fc9596acc59de48

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Biologically active molecules that reduce polyglutamine aggregation and toxicity

Autor: J. Lawrence Marsh, Leslie M. Thompson, Judit Pallos, Marc I. Diamond, Aye Aye K. Ma, Urvee A. Desai, Brent R. Stockwell

Publikováno v: Desai, UA; Pallos, J; Ma, AAK; Stockwell, BR; Thompson, LM; Marsh, JL; et al.(2006). Biologically active molecules that reduce polyglutamine aggregation and toxicity. HUMAN MOLECULAR GENETICS, 15(13), 2114-2124. doi: 10.1093/hmg/ddl135. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/30f8x4vz

Polyglutamine expansion in certain proteins causes neurodegeneration in inherited disorders such as Huntington disease and X-linked spinobulbar muscular atrophy. Polyglutamine tracts promote protein aggregation in vitro and in vivo with a strict leng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2aec5832e204a01b56be1abb208ac6
https://doi.org/10.1093/hmg/ddl135

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The structural basis of androgen receptor activation: Intramolecular and intermolecular amino–carboxy interactions

Autor: Aye Aye K. Ma, Sabine Borngraeber, Xavier Carbonell, Marc I. Diamond, Martin Guerbadot, Mark S. Chapman, Jeffrey N. Miner, Fred Schaufele

Publikováno v: Proceedings of the National Academy of Sciences. 102:9802-9807

Nuclear receptors (NRs) are ligand-regulated transcription factors important in human physiology and disease. In certain NRs, including the androgen receptor (AR), ligand binding to the carboxy-terminal domain (LBD) regulates transcriptional activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b60da823f4b35621e5c837117fd908d
https://doi.org/10.1073/pnas.0408819102

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Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease

Autor: Yong Huang, Michael T. Matthes, Douglas Yasumura, Matthew M. LaVail, Mei Li, Francis C. Szoka, Aye Aye K. Ma, Gregory Nielson, Haidong Yang, Marc I. Diamond

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e56026 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c954d4ed0dc1ee027aef9a609b3f1f
https://pubmed.ncbi.nlm.nih.gov/23409115

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A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor

Autor: Aye Aye K. Ma, J. Lawrence Marsh, Urvee A. Desai, Jieya Shao, Marc I. Diamond, Leslie M. Thompson, Judit Pallos, Sonia K Pollitt

Publikováno v: Pollitt, SK; Pallos, J; Shao, J; Desai, UA; Ma, AAK; Thompson, LM; et al.(2003). A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor. Neuron, 40(4), 685-694. doi: 10.1016/S0896-6273(03)00697-4. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5457t1s5

Many neurodegenerative diseases, including tauopathies, Parkinson's disease, amyotrophic lateral sclerosis, and the polyglutamine diseases, are characterized by intracellular aggregation of pathogenic proteins. It is difficult to study modifiers of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18691688da4a697a10077cd8b2e74ba8

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