HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.

Autor: Aydan Salman-Dilgimen, Pierre-Olivier Hardy, Justin D Radolf, Melissa J Caimano, George Chaconas

Publikováno v: PLoS Pathogens, Vol 9, Iss 12, p e1003841 (2013)

The Lyme disease spirochete Borrelia burgdorferi must differentially express genes and proteins in order to survive in and transit between its tick vector and vertebrate reservoir. The putative DEAH-box RNA helicase, HrpA, has been recently identifie

Externí odkaz: https://doaj.org/article/7497a13b55354b368ddbd33557fb7c82

Construction and Characterization of a Borrelia burgdorferi Strain with Conditional Expression of the Essential Telomere Resolvase, ResT

Autor: George Chaconas, Nicholas J. Bandy, Aydan Salman-Dilgimen

Publikováno v: Journal of Bacteriology. 196:2396-2404

Borrelia species are unique in the bacterial world in possessing segmented genomes which sometimes contain over 20 genetic elements. Most elements are linear and contain covalently closed hairpin ends requiring a specialized process, telomere resolut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb4ee437a6ed358bffbf03c933526db
https://doi.org/10.1128/jb.01435-13

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules

Autor: Pierre Olivier Hardy, Rhodaba Ebady, Yi-Pin Lin, Jon T. Skare, Hong Zhou, John M. Leong, Paul Kubes, Jing Wu, Tara J. Moriarty, Aydan Salman-Dilgimen, Meiqing Shi, Eric H. Weening, Tanya Odisho, George Chaconas

Publikováno v: Molecular Microbiology. 86:1116-1131

Summary Systemic dissemination of microbial pathogens permits microbes to spread from the initial site of infection to secondary target tissues and is responsible for most mortality due to bacterial infections. Dissemination is a critical stage of di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b1143641dff3600afc293ff8ba89ee5
https://doi.org/10.1111/mmi.12045

Alkaline serine protease from halotolerantBacillus licheniformis BA17

Autor: Burhan Arikan, Aydan Salman Dilgimen, Aziz Akin Denizci, Selçuk Öztürk, Müserref Özeren-Morgan, Dilek Kazan

Publikováno v: Annals of Microbiology. 59:83-90

An alkaline protease from halotolerant Bacillus licheniformis BA17, isolated from Van Lake in Turkey, was purified 5.4 fold with 58% yield. The molecular weight was 19.7 kDa and the optimum temperature and pH were 60 °C and 10, respectively. The hal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a758f6d25c376f06a9e2472ac8620d04
https://doi.org/10.1007/bf03175603

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

Autor: Maria-Jesus Sanz, Pierre-Olivier Hardy, Christopher H. Mody, Tara J. Moriarty, Adriana Marques, Woo-Yong Lee, Roman Krawetz, George Chaconas, Connie H.Y. Wong, Aydan Salman-Dilgimen, Paul Kubes

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America Vol. 111 Issue 38: pp. 13936-13941
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname

CXCR6-GFP(+) cells, which encompass 70% invariant natural killer T cells (iNKT cells), have been found primarily patrolling inside blood vessels in the liver. Although the iNKT cells fail to interact with live pathogens, they do respond to bacterial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c71876f0622c7a808ef1d1913fd51d8
http://hdl.handle.net/10550/44429