Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Ayaz Najafov"'
Autor:
Huibing Wang, Weiwei Qi, Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan, Bing Shan, Ying Li, Zheng-Jiang Zhu, Junying Yuan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism
Externí odkaz:
https://doaj.org/article/4294aac17a8b4f399739cdbf82ea2a17
Autor:
Youqian Wu, Chao Zhang, Xiaolan Liu, Zhengfu He, Bing Shan, Qingxin Zeng, Qingwei Zhao, Huaying Zhu, Hongwei Liao, Xufeng Cen, Xiaoyan Xu, Mengmeng Zhang, Tingjun Hou, Zhe Wang, Huanhuan Yan, Shuying Yang, Yaqin Sun, Yanying Chen, Ronghai Wu, Tingxue Xie, Wei Chen, Ayaz Najafov, Songmin Ying, Hongguang Xia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The regulation of PD-L1 via proteasomal degradation is unclear. Here, the authors show that EGFR inhibition activates GSK3 α to promote PD-L1 phosphorylation, which leads to PD-L1 ubiquitination and proteasome mediated degradation by ARIH1 E3 ligase
Externí odkaz:
https://doaj.org/article/4df5793a5b60480c842c52657fc986f7
Autor:
Xufeng Cen, Yanying Chen, Xiaoyan Xu, Ronghai Wu, Fusheng He, Qingwei Zhao, Qiming Sun, Cong Yi, Jie Wu, Ayaz Najafov, Hongguang Xia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Previous work suggests that mitophagy in neurons is could be therapeutic in Alzheimer’s disease (AD). Here, the authors screen a library of drugs and identify UMI-77, a mitophagy inducer with beneficial effects in an AD mouse model, by binding MCL-
Externí odkaz:
https://doaj.org/article/0778027b69704574ad5fc700df51b76a
Autor:
Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira, Junying Yuan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
TNFα can promote three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. Here the authors show that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating thi
Externí odkaz:
https://doaj.org/article/bebdf94e5c8e42219dc5cf8b4c649af2
Autor:
Jamil Najafov, Ayaz Najafov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-4 (2017)
Abstract Modern high-throughput screening methods allow researchers to generate large datasets that potentially contain important biological information. However, oftentimes, picking relevant hits from such screens and generating testable hypotheses
Externí odkaz:
https://doaj.org/article/b760f2eb256a480985d2a92af79cbab3
Autor:
Ayaz Najafov, Ioannis K Zervantonakis, Adnan K Mookhtiar, Patricia Greninger, Ryan J March, Regina K Egan, Hoang Son Luu, Daniel G Stover, Ursula A Matulonis, Cyril H Benes, Junying Yuan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2005756 (2018)
Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway. The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and necroptotic potential have been previously reported in several cancer cel
Externí odkaz:
https://doaj.org/article/2e140e19f51e4e62a0336885df594129
Autor:
Dimitry Ofengeim, Yasushi Ito, Ayaz Najafov, Yaoyang Zhang, Bing Shan, Judy Park DeWitt, Juanying Ye, Xumin Zhang, Ansi Chang, Helin Vakifahmetoglu-Norberg, Jiefei Geng, Benedicte Py, Wen Zhou, Palak Amin, Jonilson Berlink Lima, Chunting Qi, Qiang Yu, Bruce Trapp, Junying Yuan
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1836-1849 (2015)
Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine implicated in MS, can activate necroptosis, a ne
Externí odkaz:
https://doaj.org/article/0178a95c3a344ac1b03cbe265055d0cc
Autor:
Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh
Publikováno v:
eLife, Vol 5 (2016)
The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated E3 ubiquitin ligase ZNRF2
Externí odkaz:
https://doaj.org/article/22e15996b1d34e3eb9da975e48348923
Autor:
Tao Zhang, Kangyun Dong, Wei Liang, Daichao Xu, Hongguang Xia, Jiefei Geng, Ayaz Najafov, Min Liu, Yanxia Li, Xiaoran Han, Juan Xiao, Zhenzhen Jin, Ting Peng, Yang Gao, Yu Cai, Chunting Qi, Qing Zhang, Anyang Sun, Marta Lipinski, Hong Zhu, Yue Xiong, Pier Paolo Pandolfi, He Li, Qiang Yu, Junying Yuan
Publikováno v:
eLife, Vol 4 (2015)
Autophagy is an important intracellular catabolic mechanism involved in the removal of misfolded proteins. Atg14L, the mammalian ortholog of Atg14 in yeast and a critical regulator of autophagy, mediates the production PtdIns3P to initiate the format
Externí odkaz:
https://doaj.org/article/3e868138a8c44057ad78966bdd7397e1
Autor:
Ayaz Najafov, Tuncay Seker, Ipek Even, Gerta Hoxhaj, Osman Selvi, Duygu Esen Ozel, Ahmet Koman, Necla Birgül-İyison
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37013 (2012)
Wnt/β-catenin signalling pathway plays important roles in embryonic development and carcinogenesis. Overactivation of the pathway is one of the most common driving forces in major cancers such as colorectal and breast cancers. The downstream effecto
Externí odkaz:
https://doaj.org/article/209912e2be2441afa0af930f9b18ade5