Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.

Autor: Kim D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Herdeis L; Boehringer Ingelheim, Vienna, Austria., Rudolph D; Boehringer Ingelheim, Vienna, Austria., Zhao Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Böttcher J; Boehringer Ingelheim, Vienna, Austria., Vides A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ayala-Santos CI; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pourfarjam Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cuevas-Navarro A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Xue JY; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mantoulidis A; Boehringer Ingelheim, Vienna, Austria., Bröker J; Boehringer Ingelheim, Vienna, Austria., Wunberg T; Boehringer Ingelheim, Vienna, Austria., Schaaf O; Boehringer Ingelheim, Vienna, Austria., Popow J; Boehringer Ingelheim, Vienna, Austria., Wolkerstorfer B; Boehringer Ingelheim, Vienna, Austria., Kropatsch KG; Boehringer Ingelheim, Vienna, Austria., Qu R; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sang B; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Li C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., McConnell DB; Boehringer Ingelheim, Vienna, Austria., Kraut N; Boehringer Ingelheim, Vienna, Austria., Lito P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. litop@mskcc.org.

Publikováno v: Nature [Nature] 2023 Jul; Vol. 619 (7968), pp. 160-166. Date of Electronic Publication: 2023 May 31.